Testing association in the presence of linkage - A powerful score for binary traits

Genetic Epidemiology

Volumn 31, Issue 6, 2007, Pages 528-540

  Jonasdottir, Gudrun ^a   Humphreys, Keith ^a   Palmgren, Juni ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Family based studies; FBAT; Random effects

Indexed keywords

ALCOHOLISM; ARTICLE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENOTYPE; INHERITANCE; MATHEMATICAL MODEL; POPULATION MODEL; SIMULATION; ALGORITHM; ALLELE; BIOLOGICAL MODEL; COMPUTER SIMULATION; FAMILY HEALTH; GENETICS; HUMAN; METHODOLOGY; PHENOTYPE; QUANTITATIVE TRAIT; STATISTICAL MODEL; THEORETICAL MODEL;

ALCOHOLISM; ALGORITHMS; ALLELES; COMPUTER SIMULATION; FAMILY HEALTH; GENOTYPE; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; MODELS, STATISTICAL; MODELS, THEORETICAL; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE; RESEARCH DESIGN;

EID: 35248853854     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20226     Document Type: Article

References (19)

1. Bass M, Martin E, Hauser E. 2004. Pedigree generation for analysis of genetic linkage and association. Pacific Sympos Biocomput 9:93-103.
2. Clayton D. 1999. A generalization of the transmission/disequilibrium test for uncertain haplotype transmission. Am J Hum Genet 65:1170-1177.
3. Conaway M. 1990. A random effects model for binary data. Biometrics 46:317-328.
4. Edenberg H, Bierut L, Boyce P, Cao M, Cawley S, Chiles R, Doheny K, Hansen M, Hinrichs T, Jones K, Kelleher M, Kennedy G, Liu G, Marcus G, McBride C, Murray S, Oliphant A, Pettengill J, Porjesz B, Pugh E, Rice J, Rubano T, Shannon S, Steeke R, Tischfield J, Tsai Y, Zhang C, Begleiter H. 2005. Description of the data from the collaborative study on the genetics of alcoholism (coga) and single-nucleotide polymorphism genotyping for genetic analysis workshop 14. BMC Genet 6(Suppl 1):S2.
5. Fulker D, Cherny S, Sham P, Hewitt J. 1999. Combined linkage and association sib-pairs analysis for quantitative traits. Am J Hum Genet 64:259-267.
6. Kruglyak L, Daly M, Reeve-Daly M, Lander E. 1996. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
7. Kruglyak L, Lander E. 1995. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454.
8. Lake S, Blacker D, Laird N. 2000. Family-based tests of association in the presence of linkage. Am J Hum Genet 67:1515-1525.
9. Lewontin R, Kojima K. 1960. The evolutionary dynamics of complex polymorphisms. Evolution 14:458-472.
10. Martin E, Bass M, Hauser E, Kaplan N. 2003. Accounting for linkage in family-based tests of association with missing parental genotypes. Am J Hum Genet 73:1016-1026.
11. Rabinowitz D, Laird N. 2000. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50:211-223.
12. R Development Core Team. 2006. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org.
13. Sham P, Cherny S, Purcell S, Hewitt J. 2000. Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am J Hum Genet 66:1616-1630.
14. Shih M-C, Whittemore A. 2002. Tests for genetic association using family data. Genet Epidemiol 22:128-145.
15. Spielman R, McGinnis R, Ewens W. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (iddm). Am J Hum Genet 52:506-516.
16. Whittemore A, Tu I-P. 2000. Detection of disease genes by use of family data. I. Likelihood-based theory. Am J Hum Genet 66:1328-1340.
17. Zhong X, Li H. 2004. Score tests of genetic association in the presence of linkage based on the additive genetic gamma frailty model. Biostatistics 5:307-327.
18. Zhong X, Zhang H. 2005. Linkage analysis and association analysis in the presence of linkage using age at onset of coga alcoholism data. BMC Genet 6 (Suppl 1):S31.
19. Zhu X, Cooper R, Kan D, Cao G, Wu X. 2005. A genome-wide linkage and association study using coga data. BMC Genet 6(Suppl 1):S128.