Therapeutic monitoring of mycophenolic acid: Is there clinical utility?

American Journal of Transplantation

Volumn 7, Issue 11, 2007, Pages 2441-2442

  West Thielke, P ^a   Kaplan, B ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ACUTE GRAFT REJECTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MONITORING; DRUG SAFETY; EDITORIAL; FOLLOW UP; HIGH RISK PATIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; PATIENT MONITORING; POLYOMA VIRUS; PRIORITY JOURNAL; PROPHYLAXIS; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; TREATMENT OUTCOME;

BAYES THEOREM; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MONITORING, PHYSIOLOGIC; MYCOPHENOLIC ACID; SAFETY; TRANSPLANTATION IMMUNOLOGY;

EID: 35248842374     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01963.x     Document Type: Editorial

References (6)

1. van Gelder T, Hilbrands LB, Varenterghem Y et al. A randomized double blind, multicenter plasma concentration controlled study of the safety and efficacy of oral mycophenolate mofetil for the prevention of acute rejection after kidney transplantation. Transplantation 1999 68 : 261 266.
2. Kiberd BA, Lawen J, Fraser AD, Keough-Ryan T, Belitsky P. Early adequate mycophenolic acid exposure is associated with less rejection in kidney transplantation. Am J Transplant 2004 4 : 1079 1083.
3. Kuypers DR, Claes K, Evenepoel P, Maes B, Vanrenterghem Y. Clinical efficacy and toxicity profile of tacrolimus and mycophenolic acid in relation to combined long-term pharmacokinetics in de novo renal allograft recipients. Clin Pharmacol Ther 2004 75 : 434 447.
4. Pillans PI, Rigby RJ, Kubler P et al. A retrospective analysis of mycophenolic acid and cyclosporin concentrations with acute rejection in renal transplant recipients. Clin Biochem 2001 34 : 77 81.
5. van Gelder T, Le Meur Y, Shaw LM et al. Therapeutic drug monitoring of mycophenolate mofetil in transplantation. Ther Drug Monit 2006 28 : 145 154.
6. Le Meur Y, Büchler M, Thierry A et al. Individualized mycophenolate mofetil dosing based on drug exposure significantly improves patient outcomes after renal transplantation. Am J Transplant (in press).