Support for involvement of the AHI1 locus in schizophrenia

European Journal of Human Genetics

Volumn 15, Issue 9, 2007, Pages 988-991

  Ingason, Andres ^b   Sigmundsson, Thordur ^a   Steinberg, Stacy ^b   Sigurdsson, Engilbert ^a   Haraldsson, Magnus ^a   Magnusdottir, Brynja B ^a   Frigge, Michael L ^b   Kong, Augustine ^b   Gulcher, Jeffrey ^b   Thorsteinsdottir, Unnur ^b   Stefansson, Kari ^b   Petursson, Hannes ^a   Stefansson, Hreinn ^b  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^b DECODE GENETICS   (Iceland)

Author keywords

6q23; AHI1; Association; Linkage; PDE7B; Schizophrenia

Indexed keywords

AHI 1 PROTEIN, HUMAN; AHI-1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CASE CONTROL STUDY; GENETIC MARKER; GENETICS; HUMAN; ICELAND; SCHIZOPHRENIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CASE-CONTROL STUDIES; GENETIC MARKERS; HUMANS; ICELAND; SCHIZOPHRENIA;

EID: 35248834207     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201848     Document Type: Article

References (17)

1. Sullivan PF, Kendler KS, Neale MC: Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60: 1187-1192. (Pubitemid 37494071)
2. Lewis CM, Levinson DF, Wise LH et al: Genome scan metaanalysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 2003; 73: 34-48. (Pubitemid 36793778)
3. Martinez M, Goldin LR, Cao Q et al: Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q. Am J Med Genet 1999; 88: 337-343. (Pubitemid 29372245)
4. Levinson DF, Holmans P, Straub RE et al: Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. Am J Hum Genet 2000; 67: 652-663. (Pubitemid 30659596)
5. Cao Q, Martinez M, Zhang J et al: Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. Genomics 1997; 43: 1-8. (Pubitemid 27310516)
6. Levi A, Kohn Y, Kanyas K et al: Fine mapping of a schizophrenia susceptibility locus at chromosome 6q23: increased evidence for linkage and reduced linkage interval. Eur J Hum Genet 2005; 13: 763-771. (Pubitemid 40846849)
7. Lerer B, Segman RH, Hamdan A et al: Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. Mol Psychiatry 2003; 8: 488-498. (Pubitemid 36829691)
8. Amann-Zalcenstein D, Avidan N, Kanyas K et ah. AHI1, a pivotal neurodevelopmental gene, and C6orf217 are associated with susceptibility to schizophrenia. Eur J Hum Genet 2006; 14: 1111-1119. (Pubitemid 44463970)
9. Ferland RJ, Eyaid W, Collura RV et al: Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome. Nat Genet 2004; 36: 1008-1013. (Pubitemid 39167500)
10. Louie CM, Gleeson JG: Genetic basis of Joubert syndrome and related disorders of cerebellar development. Hum Mol Genet 2005; 14 Spec No 2: R235-R242. (Pubitemid 41631892)
11. Spitzer RL, Endicott J, Robins E: Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 1978; 35: 773-782. (Pubitemid 9064061)
12. Endicott J, Spitzer RL: A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978; 35: 837-844. (Pubitemid 9076798)
13. Amundadottir LT, Sulem P, Gudmundsson J et al: A common variant associated with prostate cancer in European and African populations. Nat Genet 2006; 38: 652-658. (Pubitemid 43927306)
14. Gretarsdottir S, Thorleifsson G, Reynisdottir ST et al: The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet 2003; 35: 131-138. (Pubitemid 37187631)
15. Grant SF, Thorleifsson G, Reynisdottir I et al: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320-323.
16. Sasaki T, Kotera J, Yuasa K, Omori K: Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 2000; 271: 575-583. (Pubitemid 30444670)
17. Sasaki T, Kotera J, Omori K: Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/ cyclic AMP-response element binding protein pathway in primary striatal neurons. J Neurochem 2004; 89: 474-483. (Pubitemid 38495995)