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Volumn 15, Issue 23, 2007, Pages 7391-7398
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Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: Derivatives of irbesartan key intermediate
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Author keywords
2 Butyl 1,3 diaza spiro 4,4 non 1 en 4 one; Acetylcholinesterase inhibitors; Aralkyl halides; Irbesartan
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Indexed keywords
2 [2 (2 BUTYL 4 OXO 1,3 DIAZSPIROL[4,4]NON 1 EN 3 YL)ETHYL]ISOIN DOLE 1,3 DIONE;
2 BUTYL 1,3 DIAZA SPIRO[4,4]NON 1 EN 4 ONE;
2 BUTYL 3 (4 NITROBENZYL) 1,3 DIAZASPIROL[4,4]NON 1 EN 4 ONE;
2 BUTYL 3 (6 METHYLBENZO[1,3]DIOXOL 5 YLMETHYL) 1,3 DIAZSPIROL[4,4]NON 1 EN 4 ONE;
2 BUTYL 3 [2 (4 CHLOROPHENYL) 2 OXOETHYL] 1,3 DIAZSPIROL[4,4]NON 1 EN 4 ONE;
2 BUTYL 3 [2' (1 TRITYL TETRAZOL 5 YL)BIPHENYL] 1,3 DIAZSPIROL[4,4]NON 1 EN 4 ONE;
3 (2 BROMO 4,5 DIMETHOXYBENZYL) 2 BUTYL 1,3 DIAZASPIROL[4,4]NON 1 EN 4 ONE;
3 (4 BROMOBENZYL) 2 BUTYL 1,3 DIAZASPIRO[4,4]NON 1 EN 4 ONE;
4' (2 BUTYL 4 OXO 1,3 DIAZA SPIRO[4,4]NON 1 EN 3 YLMETHYL)BIPHENYL 2 CARBONITRILE;
4' (2 BUTYL 4 OXO 1,3 DIAZASPIRO[4,4]NON 1 EN 3 YLMETHYL)BIPHE NYL 2 CARBOXYLIC ACID METHYL ESTER;
4' (2 BUTYL 4 OXO 1,3 DIAZASPIRO[4,4]NON 1 EN 3 YLMETHYL)BIPHE NYL 2 CARBOXYLIC ACID TERT BUTYL ESTER;
CHOLINESTERASE INHIBITOR;
HALIDE;
IRBESARTAN;
NEOSTIGMINE;
POTASSIUM CARBONATE;
UNCLASSIFIED DRUG;
ANALYTIC METHOD;
ARTICLE;
COLORIMETRY;
DRUG MECHANISM;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
MICROWAVE IRRADIATION;
SPECTROSCOPY;
ACETYLCHOLINESTERASE;
ANIMALS;
BIPHENYL COMPOUNDS;
BRAIN;
CHOLINESTERASE INHIBITORS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG EVALUATION, PRECLINICAL;
EELS;
ENZYME ACTIVATION;
HUMANS;
INHIBITORY CONCENTRATION 50;
MOLECULAR STRUCTURE;
RATS;
SPIRO COMPOUNDS;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
TETRAZOLES;
ELECTROPHORUS ELECTRICUS;
RATTUS;
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EID: 35148899719
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2007.07.014 Document Type: Article |
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Times cited : (22)
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References (18)
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