Substance P induces intestinal wound healing via fibroblasts - Evidence for a TGF-β-dependent effect

International Journal of Colorectal Disease

Volumn 22, Issue 12, 2007, Pages 1475-1480

  Felderbauer, Peter ^a   Bulut, Kerem ^a   Hoeck, Karoline ^b   Deters, Susanne ^a   Schmidt, Wolfgang E ^a   Hoffmann, Peter ^b  

^a ST JOSEF HOSPITAL   (Germany)

^b KLINIKEN ESSEN MITTE   (Germany)

Author keywords

CGRP; IBD; Inflammation; Neuropeptides; SP

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CALCITONIN GENE RELATED PEPTIDE; SUBSTANCE P; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL MIGRATION; CELL STIMULATION; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; FIBROBLAST CULTURE; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; MITOSIS INHIBITION; MONOLAYER CULTURE; MUCOSAL IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; SENSORY NERVE; SUPERNATANT; WOUND HEALING;

ANIMALS; CACO-2 CELLS; CALCITONIN GENE-RELATED PEPTIDE; CELL MOVEMENT; CELL PROLIFERATION; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; PARACRINE COMMUNICATION; RATS; SUBSTANCE P; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 35148868646     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-007-0321-z     Document Type: Article

References (21)

1. Ciacci C, Lind SE, Podolsky DK (1993) Transforming growth factor beta regulation of migration in wounded rat intestinal epithelial monolayers. Gastroenterology 105:93-101
2. Dignass AU, Podolsky DK (1993) Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor beta. Gastroenterology 105:1323-1332
3. Dignass AU, Podolsky DK (1996) Interleukin 2 modulates intestinal epithelial cell function in vitro. Exp Cell Res 225:422-429
4. Dignass AU, Stow JL, Babyatsky MW (1996) Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta. Gut 38:687-693
5. Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK (2003) Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 162:597-608
6. Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24:739-768
7. Eysselein VE, Reinshagen M, Cominelli F, Sternini C, Davis W, Patel A, Nast CC, Bernstein D, Anderson K, Khan H et al (1991) Calcitonin gene-related peptide and substance P decrease in the rabbit colon during colitis. A time study. Gastroenterology 101:1211-1219
8. Reinshagen M, Flamig G, Ernst S, Geerling I, Wong H, Walsh JH, Eysselein VE, Adler G (1998) Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury. J Pharmacol Exp Ther 286:657-661
9. Hoffmann P, Mazurkiewicz J, Holtmann G, Gerken G, Eysselein VE, Goebell H (2002) Capsaicin-sensitive nerve fibres induce epithelial cell proliferation, inflammatory cell immigration and transforming growth factor-alpha expression in the rat colonic mucosa in vivo. Scand J Gastroenterol 37:414-422
10. Bockmann S (2002) Substance P (NK(1)) receptor expression by human colonic epithelial cell line Caco-2. Peptides 23:1783-1791
11. Goode T, O'Connor T, Hopkins A, Moriarty D, O'Sullivan GC, Collins JK, O'Donoghue D, Baird AW, O'Connell J, Shanahan F (2003) Neurokinin-1 receptor (NK-1R) expression is induced in human colonic epithelial cells by proinflammatory cytokines and mediates proliferation in response to substance P. J Cell Physiol 197:30-41
12. Hoffmann P, Dignass AU, Zeeh JM, Mazurkiewicz J, Holtmann G, Gerken G (2001) Epithelial cell-derived components induce transforming growth factor-alpha mRNA expression and epithelial cell proliferation in vitro. Eur J Gastroenterol Hepatol 13:1333-1340
13. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
14. Kim JS, Rabe KF, Magnussen H, Green JM, White SR (1995) Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins. Am J Physiol 269:L119-L126
15. McKaig BC, Makh SS, Hawkey CJ, Podolsky DK, Mahida YR (1999) Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3. Am J Physiol 276:G1087-G1093
16. Dignass AU, Sturm A (2001) Peptide growth factors in the intestine. Eur J Gastroenterol Hepatol 13:763-770
17. Babyatsky MW, Rossiter G, Podolsky DK (1996) Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 110:975-984
18. Goode T, O'Connell J, Anton P, Wong H, Reeve J, O'Sullivan GC, Collins JK, Shanahan F (2000) Neurokinin-1 receptor expression in inflammatory bowel disease: Molecular quantitation and localisation. Gut 47:387-396
19. Koch TR, Carney JA, Go VL (1987) Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases. Dig Dis Sci 32:369-376
20. Mazumdar S, Das KM (1992) Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease. Am J Gastroenterol 87:176-181
21. Bernstein CN, Robert ME, Eysselein VE (1993) Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. Am J Gastroenterol 88:908-913