The gut takes nearly all: Threonine kinetics in infants

American Journal of Clinical Nutrition

Volumn 86, Issue 4, 2007, Pages 1132-1138

  Van Der Schoor, Sophie R D ^a   Wattimena, Darcos L ^a   Huijmans, Jan ^a   Vermes, Andras ^a   Van Goudoever, Johannes B ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Intestine; Nutrition; Preterm infants; Splanchnic metabolism; Stable isotopes; Threonine

Indexed keywords

THREONINE;

ARTICLE; BIRTH WEIGHT; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; ENTERIC FEEDING; GESTATIONAL AGE; HUMAN; INFANT; ISOTOPE TRACING; KINETICS; PARENTERAL NUTRITION; PREMATURITY; PROTEIN METABOLISM; SPLANCHNIC BLOOD FLOW;

ANIMALIA;

EID: 35148864676     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/86.4.1132     Document Type: Article

References (35)

1. Ehrenkranz RA, Younes N, Lemons JA, et al. Longitudinal growth of hospitalized very low birth weight infants. Pediatrics 1999;104:280-9.
2. Stoll B, Henry JF, Reeds PJ, Yu H, Yahoor F, Burrin DG. Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein fed piglets. J Nutr 1998;128:606-14.
3. Van Goudoever JB, Stoll B, Henry JF, Burrin DG, Reeds PJ. Adaptive regulation of intestinal lysine metabolism. Proc Natl Acad Sci U S A 2000;97:11620-5.
4. Van der Schoor SRD, Van Goudoever JB, Stoll B, et al. The pattern of intestinal substrate oxidation is altered by protein restriction in pigs. Gastroenterology 2001;121:1167-75.
5. Benevenga NJ, Radcliffe BC, Egan AR. Tissue metabolism of methionine in sheep. Aust J Biol Sci 1983;36:475-85.
6. Van der Schoor SRD, Reeds PJ, Stoll B, et al. The high metabolic cost of a functional gut. Gastroenterology 2002;123:1931-40.
7. Schaart MW, Schierbeek H, Van der Schoor SR, et al. Threonine utilization is high in the intestine of piglets. J Nutr 2005;135:765-70.
8. Roberton AM, Rabel B, Harding CA, Tasman-Jones C, Harris PJ, Lee SP. Use of the ileal conduit as a model for studying human small intestinal mucus glycoprotein secretion. Am J Physiol 1991;261:G728-34.
9. Bertolo RF, Chen CZ, Law G, Pencharz PB, Ball RO. Threonine requirement of neonatal piglets receiving total parenteral nutrition is considerably lower than that of piglets receiving an identical diet intragastrically. J Nutr 1998;128:1752-9.
10. Iiboshi Y, Nezu R, Kennedy M, et al. Total parenteral nutrition decreases luminal mucous gel and increases permeability of small intestine. JPEN J Parenter Enteral Nutr 1994;18:346-50.
11. Usher RH, McLean F. Intrauterine growth of live-born caucasian infants at sea level: standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation. J Pediatr 1969;74:901-10.
12. Rautonen J, Makela A, Boyd H, Apajasalo M, Pohjavuori M. CRIB and SNAP: assessing the risk of death for preterm neonates. Lancet 1994;343:1272-3.
13. Perman JA, Barr RG, Watkins JB. Sucrose malabsorption in children; a noninvasive diagnosis by interval breath hydrogen determination. J Pediatr 1978;93:17-22.
14. Van der Schoor SRD, De Koning BA, Wattimena DL, Tibboel D, Van Goudoever JB. Validation of the direct nasopharyngeal sampling method for collection of expired air in preterm neonates. Pediatr Res 2004;55:50-4.
15. 13C] bicarbonate for metabolic studies in preterm infants: intragastric versus intravenous administration. Pediatr Res 2005;58:861-4.
16. Chaves Das Neves HJ, Vasconcelos AM. Capillary gas chromatography of amino acids, including asparagine and glutamine: sensitive gas chromatographic-mass spectrometric and selected ion monitoring gas chromatographic-mass spectrometric detection of the N,O(S)-tert. -butyldimethylsilyl derivatives. J Chromatogr 1987;392:249-58.
17. Zuijdgeest-van Leeuwen SD, Van den Berg JW, Wattimena JL, et al. Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects. Metabolism 2000;49:931-6.
18. Steele R. Influence of glucose loading and of injected insulin on hepatic glucose output. Proc N Y Acad Sci 1959;82:420-30.
19. Tserng K, Kalhan SC. Calculation of substrate turnover rate in stable isotope tracer studies. Am J Physiol Endocrinol Metab 1983;245:E308-11.
20. Van Goudoever JB, Sulkers EJ, Chapman TE, et al. Glucose kinetics and glucoregulatory hormone levels in ventilated, preterm infants on the first day of life. Pediatr Res 1993;33:553-9.
21. Wu PYK, Edwards N, Storm MC. Plasma amino acid pattern in normal breast fed infants. J Pediatr 1986;109:347-9.
22. Edelstone DI, Holzman IR. Oxygen consumption by the gastrointestinal tract and liver in conscious newborn lambs. Am J Physiol 1981;241:G289-93.
23. Ebner S, Schoknecht P, Reeds P, Burrin D. Growth and metabolism of gastrointestinal and skeletal muscle tissues in protein-malnourished neonatal pigs. Am J Physiol 1994;266:R1736-43.
24. McNurlan MA, Garlick PJ. Contribution of rat liver and gastrointestinal tract to whole-body protein synthesis in the rat. Biochem J 1980;186:381-3.
25. Berseth CL, Nordyke C. Enteral nutrients promote postnatal maturation of intestinal motor activity in preterm infants. Am J Physiol 1993;264:G1046-51.
26. Rojahn A, Lindgren CG. Enteral feeding in infants <1250 g starting within 24 h post-partum. Eur J Pediatr 2001;160:629-32.
27. Berseth CL. Gut motility and the pathogenesis of necrotizing enterocolitis. Clin Perinatol 1994;21:263-70.
28. Thureen PJ, Hay WW Jr. Early aggressive nutrition in preterm infants. Semin Neonatol 2001;6:403-15.
29. Stoll B, Chang X, Fan MZ, Reeds PJ, Burrin DG. Enteral nutrient intake level determines intestinal protein synthesis and accretion rates in neonatal pigs. Am J Physiol Gastrointest Liver Physiol 2000;279:G288-94.
30. Burrin DG, Stoll B, Jiang R, et al. Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough? Am J Clin Nutr 2000;71:1603-10.
31. Bengmark S, Jeppsson B. Gastrointestinal surface protection and mucosa reconditioning. JPEN J Parenter Enteral Nutr 1995;19:410-5.
32. Faure M, Moennoz D, Montignon F, Mettraux C, Breuille D, Ballevre O. Dietary threonine restriction specifically reduces intestinal mucin synthesis in rats. J Nutr 2005;135:486-91.
33. Law GK, Bertolo RF, Adjiri-Awere A, Pencharz PB, Ball RO. Adequate oral threonine is critical for mucin production and gut function in neonatal piglets. Am J Physiol Gastrointest Liver Physiol 2007;292:G1293-301.
34. Darling PB, Dunn M, Sarwar G, Brookes S, Ball RO, Pencharz PB. Threonine kinetics in preterm infants fed their mothers' milk or formula with various ratios of whey to casein. Am J Clin Nutr 1999;69:105-14.
35. Parimi PS, Gruca LL, Kalhan SC. Metabolism of threonine in newborn infants. Am J Physiol Endocrinol Metab 2005;289:E981-5.