The placental barrier in allogenic immune conflict in spontaneous early abortions: Immunohistochemical and morphological study

American Journal of Reproductive Immunology

Volumn 58, Issue 5, 2007, Pages 460-467

  Gurevich, Pavel ^a   Elhayany, Asher ^b   Milovanov, Andrey P ^c   Halperin, Reuvit ^d   Kaganovsky, Ella ^e   Zusman, Itzhak ^f   Ben hur, Herzel ^a,d  

^a Laboratory of Experimental Medicine   (Israel)

^b CLALIT HEALTH SERVICES   (Israel)

^c RESEARCH INSTITUTE OF HUMAN MORPHOLOGY   (Russian Federation)

^d ASSAF HAROFEH MEDICAL CENTER   (Israel)

^e RABIN MEDICAL CENTER   (Israel)

^f HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Allogenic conflict; Human embryos; Placental barrier; Spontaneous early abortions

Indexed keywords

FAS LIGAND; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PROTEIN BCL 2; PROTEIN P53;

ADULT; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; BLOOD PLACENTA BARRIER; CELL TYPE; CHORION VILLUS; CONTROLLED STUDY; ENDOTHELIUM; ERYTHROBLAST; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; MONOCYTE; MORPHOMETRICS; PHAGOLYSOSOME; PRIORITY JOURNAL; PROTEIN FUNCTION; SPONTANEOUS ABORTION; TROPHOBLAST;

ABORTION, SPONTANEOUS; ADULT; APOPTOSIS; CHORIONIC VILLI; DECIDUA; FEMALE; HUMANS; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; PHAGOCYTES; PREGNANCY;

EID: 35148864166     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2007.00531.x     Document Type: Article

References (22)

1. Ness RB: The consequences for human reproduction of a robust inflammatory response. Q Rev Biol 2004; 79: 383-393.
2. de Luca Brunori I, Battini L, Brunori E, Lenzi P, Paparelli A, Simonelli M, Valentino V, Genazzani AR: Placental barrier breakage in preeclampsia: Ultrastructural evidence. Eur J Obstetr Gynecol Reprod Biol 2005; 118: 182-189
3. Sargent IL., Redman CWG, Starkey PM: The placenta as a graft. In The Human Placenta, A Guide for Clinicians and Scientists, CWG Redman, IL Sargent, PM Starkey (eds). Oxford, UK, Blackwell Sci Publ, 1993, pp 334-361.
4. Guzman Sanchez A, Gonzalez Moreno J, Castaneda Arellano I, Villa Villagrana F: ImmunopathologyCof early abortion: current status. Gynecol Obstet Mex 1997; 65: 262-265.
5. Jerzak M, Bischof P: Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal-foetal interface and in the trophoblast remodeling. Eur J Obstet Gynecol Reprod Biol 2002; 100: 138-142.
6. Ohshima K, Nakashima M, Sonoda K, Kikuchi M, Watanabe T: Expression of RCAS1 and FasL in human trophoblast and uterine glands during pregnancy: the possible role in immune privilege. Clin Exp Immunol 2001; 123: 481-486.
7. Huddleston H, Schust DJ: Immune interactions at the maternal-fetal interface: A focus on antigen presentation. Am J Reprod Immunol 2004; 51: 283-289.
8. Gurevich P, Erina S, Gershon S, Zusman I: The role of the fetal immune system in the pathogenesis of RhD-hemolytic disease of newborns. Human Antibodies 1997; 8: 76-89.
9. Sargent IL: The placenta and recurrent early pregnancy loss. In The Human Placenta, A Guide for Clinicians and Scientists, CWG Redman, IL Sargent, PM Starkey (eds). Oxford, UK, Blackwell Sci Publ, 1993, pp 113-132.
10. Chan CC, Lao TT, Cheung AN: Apoptotic and proliferative activities in first trimester placentae. Placenta 1999; 20: 223-227.
11. Ben-Hur H, Gurevich P, Elhayany A, Avinoach I, Schneider DF, Zusman I: Transport of maternal immunoglobulins through the human placental barrier in normal pregnancy and during inflammation. Int J Mol Med 2005; 16: 401-407.
12. Huppertz B, Frank HG, Kaufmann P: The apoptosis cascade -morphological and immunohistochemical methods for its visualization. Anat Embryol 1999; 200: 1-18.
13. Chan CC, Lao TT, Cheung AN: Apoptosis in human placenta. Am J Obstet Gynecol 1998; 179: 1377-1378.
14. Bulla R, Bossi F, Radillo O, de Seta F, Tedesco F: Placental trophoblast and endothelial cells as target of maternal immune response. Autoimmunity 2003; 36: 11-18.
15. Kokawa K, Shikone T, Nakano R: Apoptosis in human chorionic villi and decidua during normal embryonic development and spontaneous abortion in the first trimester. Placenta 1998; 19: 21-26.
16. Majno G, Joris I: Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 1995; 146: 3-15.
17. BosmaP FT, Visser BC, van Oeveren J: Apoptosis: pathophysiology of programmed cell death. Pathol Res Pract 1996; 192: 676-683.
18. Uchide N, Ohyama K, Bessho T, Toyoda H: Induction of pro-inflammatory cytokine gene expression and apoptosis in human chorion cells of fetal membranes by influenza virus infection: Possible implications for maintenance and interruption of pregnancy during infection. Med Sci Monit 2005; 11: RA7-RA16.
19. Eguchi Y, Shimizu S, Tsujimoto Y: Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 1997; 57: 1835-1840.
20. Leist M, Single B, Castoldi AF, Kühnle S, Nicotera P: Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185: 1481-1486.
21. Smith SC, Price E, Hewitt MJ, Symonds EM, Baker PN: Cellular proliferation in the placenta in normal human pregnancy and pregnancy complicated by intrauterine growth restriction. J Soc Gynecol Investig 1998; 5: 317-323.
22. Levy R, Smith SD, Yusuf K, Huettner PC, Kraus FT, Sadovsky Y, Nelson DM: Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression. Am J Obstet Gynecol 2002; 186: 1056-1061.