Arterial remodelling: An independent pathophysiological component of atherosclerotic disease progression and regression. Insights from serial pharmacological intervention trials

European Heart Journal

Volumn 28, Issue 19, 2007, Pages 2299-2300

  Schoenhagen, Paul ^a   Sipahi, Ilke ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PERINDOPRIL; PLACEBO;

ANGIOCARDIOGRAPHY; ARTERY CALCIFICATION; ATHEROSCLEROTIC PLAQUE; CLINICAL FEATURE; CLINICAL TRIAL; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DISEASE COURSE; DRUG EFFECT; DRUG MECHANISM; EDITORIAL; ENZYME INHIBITION; HUMAN; INFLAMMATION; INTERVENTION STUDY; INTRAVASCULAR ULTRASOUND; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REMISSION; TRANSLUMINAL CORONARY ANGIOPLASTY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ATHEROSCLEROSIS; DISEASE PROGRESSION; HUMANS; MULTICENTER STUDIES AS TOPIC; PERINDOPRIL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 35148843327     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehm276     Document Type: Editorial

References (11)

1. Rodriguez-Granillo GA, de Winter S, Bruining N, Ligthart JMR, García-García HM, Valgimigli M, de Feyter PJ. Effect of perindopril on coronary remodelling: insights from a multicentre, randomized study. Eur Heart J 2007;28:2326-2331. First published on August 31, 2007, doi:10.1093/eurheartj/ehm255
2. Rodriguez-Granillo GA, Bruining N, de Winter S, Vos J, Lighart JM, Deckers J, Simoons ML, Fox K, de Feyter PJ. Long-term effect of perindopril on coronary atherosclerosis progression. Am J Cardiol 2007, in press.
3. Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomized, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003;362:782-788.
4. Glagov S, Weisenberg E, Zarins C, Stankunavicius R, Kolletis G. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987;316:371-375.
5. Pasterkamp G, Schoneveld AH, van der Wal AC, Haudenschild CC, Clarijs RJ, Becker AE, Hillen B, Borst C. Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox. J Am Coll Cardiol 1998;32:655-662.
6. Schoenhagen P, Ziada KM, Kapadia SR, Crowe TD, Nissen SE, Tuzcu EM. Extent and direction of arterial remodeling in stable versus unstable coronary syndromes: an intravascular ultrasound study. Circulation 2000;101:598-603.
7. Schoenhagen P, Tuzcu EM, Apperson-Hansen C, Wang C, Wolski K, Lin S, Sipahi I, Nicholls SJ, Magyar WA, Loyd A, Churchill T, Crowe T, Nissen SE. Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial. Circulation 2006;113:2826-2834.
8. Brown BG. A direct comparison of intravascular ultrasound and quantitative coronary arteriography: implications for measures of atherosclerosis as clinical surrogates. Circulation 2007;115:1824- 1826.
9. Sipahi I, Tuzcu EM, Schoenhagen P, Nicholls SJ, Chen MS, Crowe T, Loyd AB, Kapadia S, Nissen SE. Paradoxical increase in lumen size during progression of coronary atherosclerosis: observations from the REVERSAL trial. Atherosclerosis 2006;189:229-235.
10. De Ciuceis C, Amiri F, Brassard P, Endemann DH, Touyz RM, Schiffrin EL. Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury. Arterioscler Thromb Vasc Biol 2005;25:2106-2113.
11. Sipahi I, Tuzcu EM, Schoenhagen P, Nicholls SJ, Ozduran V, Kapadia S, Nissen SE. Compensatory enlargement of human coronary arteries during progression of atherosclerosis is unrelated to atheroma burden: serial intravascular ultrasound observations from the REVERSAL trial. Eur Heart J 2006;27:1664-1670.