Survey of ALS-associated factors potentially promoting Ca2+ overload of motor neurons

Amyotrophic Lateral Sclerosis

Volumn 8, Issue 5, 2007, Pages 260-265

  Ionov, Ilya D ^a  

^a CENTER FOR THEORETICAL PROBLEMS OF PHYSICOCHEMICAL PHARMACOLOGY   (Russian Federation)

Author keywords

Amyotrophic lateral sclerosis; Calcium overload; Ischaemia; Neurotransmitter profile; NMDA receptor activation

Indexed keywords

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; CALCIUM; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NORADRENALIN; RILUZOLE; SEROTONIN; VOLTAGE GATED CHANNEL FORMING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; BLOOD LEVEL; BRAIN ISCHEMIA; CALCIUM TRANSPORT; CEREBROSPINAL FLUID LEVEL; DRUG EFFICACY; EXTRACELLULAR CALCIUM; HUMAN; MOTONEURON; MOTOR NEURON DISEASE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AMYOTROPHIC LATERAL SCLEROSIS; BRAIN CHEMISTRY; CALCIUM; CELL DEATH; CEREBRAL CORTEX; HUMANS; MOTOR NEURONS; NEUROTRANSMITTER AGENTS; RECEPTORS, GLUTAMATE;

EID: 35148832620     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/17482960701523124     Document Type: Review

References (87)

1. 2+ influx underlies potent induction of injury. J Neurosci, 16, pp. 5457-5465.
2. Appel, S. H., Beers, D., Siklos, L., Engelhardt, J. I. and Mosier, D. R. (2001) Calcium: The Darth Vader of ALS. Amyotroph Lateral Scler Other Motor Neuron Disord, 2, p. S47.
3. Arundine, M. and Tymianski, M. (2003) Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium, 34, pp. 325-337.
4. van Damme, P., Braeken, D., Callewaert, G., Robberecht, W. and Bosch, L. van den (2005) GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis. Neuropathol Exp Neurol, 64, pp. 605-612.
5. Bosch, L. van den, van Damme, P., Bogaert, E. and Robberecht, W. (2006) The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta, 1762, pp. 1068-1082.
6. Choi, D. W. (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci, 7, pp. 369-379.
7. Randall, R. D. and Thayer, S. A. (1992) Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J Neurosci, 12, pp. 1882-1895.
8. Siklos, L., Engelhardt, J., Harati, Y., Smith, R. G., Joo, F. and Appel, S. H. (1996) Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophic lateral sclerosis. Ann Neurol, 39, pp. 203-216.
9. Nicoll, R. A. and Alger, B. E. (1981) Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells. Science, 212, pp. 957-959.
10. Regan, R. F. and Choi, D. W. (1991) Glutamate neurotoxicity in spinal cord cell culture. Neuroscience, 43, pp. 585-591.
11. Choi, D. W. (1992) Excitotoxic cell death. J Neurobiol, 23, pp. 1261-1276.
12. Estevez, A. G., Stutzmann, J. M. and Barbeito, L. (1995) Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures. Eur J Pharmacol, 280, pp. 47-53.
13. Bosch, L. van den and Robberecht, W. (2000) Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity. Brain Res Bull, 53, pp. 383-388.
14. 2+-permeable AMPA receptors and selective vulnerability of motor neurons. J Neurol Sci, 180, pp. 29-34.
15. Olney, J. W., Ho, O. L. and Rhee, V. (1971) Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system. Exp Brain Res, 14, pp. 61-76.
16. Olney, J. W. (1974) Toxic effects of glutamate and related amino acids on the developing central nervous system. Heritable disorders of amino acid metabolism: Patterns of clinical expression and genetic variation, pp. 501-512. John Wiley & Sons, Inc, New York
17. Carriedo, S. G., Yin, H. Z. and Weiss, J. H. (1996) Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. J Neurosci, 16, pp. 4069-4079.
18. 2+ influx. J Neurosci Res, 63, pp. 377-387.
19. Corona, J. C. and Tapia, R. (2004) AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo. J Neurochem, 89, pp. 988-997.
20. Kalb, R. G. (1994) Regulation of motor neuron dendrite growth by NMDA receptor activation. Development, 120, pp. 3063-3071.
21. Kalb, R. G., Lidow, M. S., Halsted, M. J. and Hockfield, S. (1992) N-methyl-D-aspartate receptors are transiently expressed in the developing spinal cord ventral horn. Proc Natl Acad Sci USA, 89, pp. 8502-8506.
22. Hori, N., Tan, Y., King, M., Strominger, N. L. and Carpenter, D. O. (2002) Differential actions and excitotoxicity of glutamate agonists on motoneurons in adult mouse cervical spinal cord slices. Brain Res, 958, pp. 434-438.
23. Plaitakis, A., Berl, S. and Yahr, M. D. (1982) Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder. Science, 216, pp. 193-196.
24. Plaitakis, A. and Caroscio, J. T. (1987) Abnormal glutamate metabolism in amyotrophic lateral sclerosis. Ann Neurol, 22, pp. 575-579.
25. Rothstein, J. D., Tsai, G., Kuncl, R. W., Clawson, L., Cornblath, D. R. and Drachman, D. B. (1990) Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol, 28, pp. 18-25.
26. Rothstein, J. D., Kuncl, R., Chaudhry, V., Clawson, L., Cornblath, D. R. and Coyle, J. T. (1991) Excitatory amino acids in amyotrophic lateral sclerosis: An update. Ann Neurol, 30, pp. 224-225.
27. Iwasaki, Y., Ikeda, K. and Kinoshita, M. (1992) Plasma amino acid levels in patients with amyotrophic lateral sclerosis. J Neurol Sci, 107, pp. 219-222.
28. Shaw, P. J., Forrest, V., Ince, P. G., Richardson, J. P. and Wastell, H. J. (1995) CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration, 4, pp. 209-216.
29. Airapetian, K. V., Zavalishin, I. A., Nikitin, S. S. and Barkhatova, V. P. (2000) Physiopathological and chemopathological mechanisms of central motor disorders in amyotrophic lateral sclerosis (in Russian). Zh Nevrol Psikhiatr Im SS Korsakova, 7, pp. 33-36.
30. Spreux-Varoquaux, O., Bensimon, G., Lacomblez, L., Salachas, F., Pradat, P. F. and Forestier, N. Le (2002) Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: A reappraisal using a new HPLC method with coulometric detection in a large cohort of patients. J Neurol Sci, 193, pp. 73-78.
31. Couratier, P., Hugon, J., Sindou, P., Vallat, J. M. and Dumas, M. (1993) Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors. Lancet, 341, pp. 265-268.
32. Tikka, T. M., Vartiainen, N. E., Goldsteins, G., Oja, S. S., Andersen, P. M. and Marklund, S. L. (2002) Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease. Brain, 125, pp. 722-731.
33. Lawyer, T Jr. and Netsky, M. G. (1953) Amyotrophic lateral sclerosis. A clinicoanatomic study of fifty-three cases. AMA Arch Neurol Psychiatry, 69, pp. 171-192.
34. Mannen, T., Iwata, M., Toyokura, Y. and Nagashima, K. (1977) Preservation of a certain motoneurone group of the sacral cord in amyotrophic lateral sclerosis: Its clinical significance. J Neurol Neurosurg Psychiatry, 40, pp. 464-469.
35. Bosch, L. van den, Schwaller, B., Vleminckx, V., Meijers, B., Stork, S. and Ruehlicke, T. (2002) Protective effect of parvalbumin on excitotoxic motorneuron death. Exp Neurol, 174, pp. 150-161.
36. Alexianu, M. E., Ho, B. K., Mohamed, A. H., La Bella, V., Smith, R. G. and Appel, S. H. (1994) The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis. Ann Neurol, 36, pp. 846-858.
37. Reiner, A., Medina, L., Figueredo-Cardenas, G. and Anfinson, S. (1995) Brainstem motoneuron pools that are selectively resistant in amyotrophic lateral sclerosis are preferentially enriched in parvalbumin: Evidence from monkey brainstem for a calcium-mediated mechanism in sporadic ALS. Exp Neurol, 131, pp. 239-250.
38. Palecek, J., Lips, M. B. and Keller, B. U. (1999) Calcium dynamics and buffering in motoneurones of the mouse spinal cord. J Physiol, 520, pp. 485-502.
39. Vanselow, B. K. and Keller, B. U. (2000) Calcium dynamics and buffering in oculomotor neurons from mouse that are particularly resistant during amyotrophic lateral sclerosis (ALS)-related motoneurone disease. J Physiol, 525, pp. 433-445.
40. Meldrum, B. and Garthwaite, J. (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci, 11, pp. 379-387.
41. Rothstein, J. D. (1995) Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis. Adv Neurol, 68, pp. 7-20.
42. Heath, P. R. and Shaw, P. J. (2002) Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve, 26, pp. 438-458.
43. van Damme, P., Dewil, M., Robberecht, W. and Bosch, L. van den (2005) Excitotoxicity and amyotrophic lateral sclerosis. Neurodegener Dis, 2, pp. 147-159.
44. Plaitakis, A., Smith, J., Mandeli, J. and Yahr, M. D. (1988) Pilot trial of branched-chain amino acids in amyotrophic lateral sclerosis. Lancet, 1, pp. 1015-1018.
45. Cheramy, A., Barbeito, L., Godeheu, G. and Glowinski, J. (1992) Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo. Neurosci Lett, 147, pp. 209-212.
46. Martin, D., Thompson, M. A. and Nadler, J. V. (1993) The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol, 250, pp. 473-476.
47. Niebroj-Dobosz, I., Janik, P. and Kwiecinski, H. (2002) Effect of riluzole on serum amino acids in patients with amyotrophic lateral sclerosis. Acta Neurol Scand, 106, pp. 39-43.
48. Bensimon, G., Lacomblez, L. and Meininger, V. (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med, 330, pp. 585-591.
49. Rowland, L. P. (1996) Controversies about amyotrophic lateral sclerosis. Neurologia, 11, pp. 72-74.
50. Mitchell, D. J., O'Brien, M. R. and Joshi, M. (2006) Audit of outcomes in motor neuron disease (MND) patients treated with riluzole. Amyotroph Lateral Scler Other Motor Neuron Disord, 7, pp. 67-71.
51. Pomara, N., Singh, R., Deptula, D., Chou, J. C., Schwartz, M. B. and LeWitt, P. A. (1992) Glutamate and other CSF amino acids in Alzheimer's disease. Am J Psychiatry, 149, pp. 251-254.
52. Csernansky, J. G., Bardgett, M. E., Sheline, Y. I., Morris, J. C. and Olney, J. W. (1996) CSF excitatory amino acids and severity of illness in Alzheimer's disease. Neurology, 46, pp. 1715-1720.
53. Jimenez-Jimenez, F. J., Molina, J. A., Gomez, P., Vargas, C., de Bustos, F. and Benito-Leon, J. (1998) Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease. J Neural Transm, 105, pp. 269-277.
54. Perry, T. L. and Hansen, S. (1990) What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studies. Neurology, 40, pp. 20-24.
55. Peres, M. F., Zukerman, E., Soares, C. A. Senne, Alonso, E. O., Santos, B. F. and Faulhaber, M. H. (2004) Cerebrospinal fluid glutamate levels in chronic migraine. Cephalalgia, 24, pp. 735-739.
56. Perry, T. L., Krieger, C., Hansen, S. and Eisen, A. (1990) Amyotrophic lateral sclerosis: Amino acid levels in plasma and cerebrospinal fluid. Ann Neurol, 28, pp. 12-17.
57. Katakura, N. and Chandler, S. H. (1990) An iontophoretic analysis of the pharmacological mechanisms responsible for trigeminal motoneuronal discharge during masticatory-like activity in the guinea pig. J Neurophysiol, 63, pp. 356-369.
58. Yokota, T., Yoshino, A., Inaba, A. and Saito, Y. (1996) Double cortical stimulation in amyotrophic lateral sclerosis. Neurol Neurosurg Psychiatry, 61, pp. 596-600.
59. Ziemann, U., Winter, M., Reimers, C. D., Reimers, K., Tergau, F. and Paulus, W. (1997) Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation. Neurology, 49, pp. 1292-1298.
60. Hanajima, R. and Ugawa, Y. (1998) Impaired motor cortex inhibition in patients with ALS: Evidence from paired transcranial magnetic stimulation. Neurology, 51, pp. 1771-1772.
61. Turner, M. R., Osei-Lah, A. D., Hammers, A., Al-Chalabi, A., Shaw, C. E. and Andersen, P. M. (2005) Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS. J Neurol Neurosurg Psychiatry, 76, pp. 1279-1285.
62. Eisen, A. and Weber, M. (2000) Neurophysiological evaluation of cortical function in the early diagnosis of ALS. Amyotroph Lateral Scler Other Motor Neuron Disord, 1, p. S47.
63. Dingledine, R., Borges, K., Bowie, D. and Traynelis, S. F. (1999) The glutamate receptor ion channels. Pharmacol Rev, 51, pp. 7-61.
64. 2+ influx and astrocytic activation in cultured mouse cortical neurons and astrocytes. Synapse, 59, pp. 10-17.
65. Fuller, P. I., Reddrop, C., Rodger, J., Bellingham, M. C. and Phillips, J. K. (2006) Differential expression of the NMDA NR2B receptor subunit in motoneuron populations susceptible and resistant to amyotrophic lateral sclerosis. Neurosci Lett, 399, pp. 157-161.
66. De Belleroche, J., Recordati, A. and Rose, F. C. (1984) Elevated levels of amino acids in the CSF of motor neuron disease patients. Neurochem Pathol, 2, pp. 1-6.
67. Ziegler, M. G., Brooks, B. R., Lake, C. R., Wood, J. H. and Enna, S. J. (1980) Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis. Neurology, 30, pp. 98-101.
68. Barkhatova, V. P., Zavalishin, I. A., Kostiuk, A. V., Demina, E. G. and Moskvitina, T. A. (1996) Neurotransmitter changes in amyotrophic lateral sclerosis (in Russian). Zh Nevropatol Psikhiatr Im S S Korsakova, 4, pp. 78-85.
69. Niebroj-Dobosz, I. and Janik, P. (1999) Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS). Acta Neurol Scand, 100, pp. 6-11.
70. Sandyk, R. (2006) Serotonergic mechanisms in amyotrophic lateral sclerosis. Int J Neurosci, 116, pp. 775-826.
71. Akaike, N., Kaneda, M., Hori, N. and Krishtal, O. A. (1988) Blockade of N-methyl-D-aspartate response in enzyme-treated rat hippocampal neurons. Neurosci Lett, 87, pp. 75-79.
72. Lovinger, D. M. and Weight, F. F. (1988) Glutamate induces a depolarization of adult rat dorsal root ganglion neurons that is mediated predominantly by NMDA receptors. Neurosci Lett, 94, pp. 314-320.
73. Woodward, J. J., Brown, L. and Gonzales, R. A. (1991) Modulation of ethanol-induced inhibition of N-methyl-D-aspartate-stimulated neurotransmitter release by glycine. Alcohol Alcohol Suppl, 1, pp. 177-180.
74. Thomson, A. M., Walker, V. E. and Flynn, D. M. (1989) Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices. Nature, 338, pp. 422-424.
75. Li, J., McRoberts, J. A., Nie, J., Ennes, H. S. and Mayer, E. A. (2004) Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons. Pain, 109, pp. 443-452.
76. Larson, A. A. and Beitz, A. J. (1988) Glycine potentiates strychnine-induced convulsions: Role of NMDA receptors. J Neurosci, 8, pp. 3822-3826.
77. Stanton, P. K., Mody, I. and Heinemann, U. (1989) A role for N-methyl-D-aspartate receptors in norepinephrine-induced long-lasting potentiation in the dentate gyrus. Exp Brain Res, 77, pp. 517-530.
78. 2+-dependent AMPA receptor-mediated motoneuron death. J Neurosci, 23, pp. 4942-4950.
79. 2+ concentration in cultured cortical neurons: Role of Cl- transport. Eur J Pharmacol, 297, pp. 137-143.
80. 2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters. Neuron, 6, pp. 333-344.
81. Foehring, R. C. (1996) Serotonin modulates N- and P-type calcium currents in neocortical pyramidal neurons via a membrane-delimited pathway. J Neurophysiol, 75, pp. 648-659.
82. Penington, N. J. and Kelly, J. S. (1990) Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron. Neuron, 4, pp. 751-758.
83. Waldemar, G., Vorstrup, S., Jensen, T. S., Johnsen, A. and Boysen, G. (1992) Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: A [99mTc]-d,l-HMPAO SPECT study. J Neurol Sci, 107, pp. 19-28.
84. Kew, J. J., Leigh, P. N., Playford, E. D., Passingham, R. E., Goldstein, L. H. and Frackowiak, R. S. (1993) Cortical function in amyotrophic lateral sclerosis. A positron emission tomography study. Brain, 116, pp. 655-680.
85. Tanaka, M., Ichiba, T., Kondo, S., Hirai, S. and Okamoto, K. (2003) Cerebral blood flow and oxygen metabolism in patients with progressive dementia and amyotrophic lateral sclerosis. Neurol Res, 25, pp. 351-356.
86. Kristian, T. and Siesjo, B. K. (1998) Calcium in ischaemic cell death. Stroke, 29, pp. 705-718.
87. Arundine, M. and Tymianski, M. (2004) Molecular mechanisms of glutamate-dependent neurodegeneration in ischaemia and traumatic brain injury. Cell Mol Life Sci, 61, pp. 657-668.