Suppression of ES cell differentiation by retinol (vitamin A) via the overexpression of Nanog

Differentiation

Volumn 75, Issue 8, 2007, Pages 682-693

  Chen, Liguo ^a   Yang, Minying ^a   Dawes, Joyce ^a   Khillan, Jaspal Singh ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Oct3 4; Overexpression of Nanog; Retinoic acid; Retinol (Vitamin A); Self renewal of ES cells; Suppression of ES cell differentiation

Indexed keywords

BETA CATENIN; NANOG PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; RETINOL; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; GENE ACTIVATION; GENE OVEREXPRESSION; MOUSE; NANOG GENE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 35148832117     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1111/j.1432-0436.2007.00169.x     Document Type: Article

References (44)

1. Ang, H.L. Duester, G. (1997) Initiation of retinoid signaling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis. Dev Dyn 208 : 536 543.
2. Avilion, A.A., Nicolis, S.K., Pevny, L.H., Perez, L., Vivian, N. Lovell-Badge, R. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17 : 126 140.
3. Balmer, J.E. Blomhoff, R. (2002) Gene expression regulation by retinoic acid. J Lipid Res 43 : 1773 1808.
4. Burdon, T., Smith, A. Savatier, P. (2002) Signaling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 12 : 432 438.
5. Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S. Smith, A. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113 : 643 655.
6. Chen, A.C. Gudas, L.J. (1996) An analysis of retinoic acid-induced gene expression and metabolism in AB1 embryonic stem cells. J Biol Chem 271 : 4971 4980.
7. Clagett-Dame, M. DeLuca, H.F. (2002) The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr 22 : 347 381.
8. Daheron, L., Opitz, S.L., Zaehres, H., Lensch, W.M., Andrews, P.W., Itskovitz-Eldor, J. Daley, G.Q. (2004) LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells 22 : 770 778.
9. Darr, H., Mayshar, Y. Benvenisty, N. (2006) Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. Development 133 : 1193 1201.
10. Davis, S., Gale, N.W., Aldrich, T.H., Maisonpierre, P.C., Lhotak, V., Pawson, T., Goldfarb, M. Yancopoulos, G.D. (1994) Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266 : 816 819.
11. Ernst, M., Oates, A. Dunn, A.R. (1996) Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways. J Biol Chem 271 : 30136 30143.
12. Evans, M.J. Kaufman, M.H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292 : 154 156.
13. Hofmann, C. Eichek, G. (1994) Retinoids in development. In : Sporn, M.B., Roberts, M.B. Goodman, D.S. eds. The retinoids: biology, chemistry and medicine. New York, Raven Press, pp. 387 441.
14. Ihle, J.N. (1996) Janus kinases in cytokine signalling. Philos Trans R Soc Lond B Biol Sci 351 : 159 166.
15. Khillan, J.S. Bao, Y. (1997) Preparation of animals with a high degree of chimerism by one-step coculture of embryonic stem cells and preimplantation embryos. Biotechniques 22 : 544 549.
16. Kuroda, T., Tada, M., Kubota, H., Kimura, H., Hatano, S.Y., Suemori, H., Nakatsuji, N. Tada, T. (2005) Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol 25 : 2475 2485.
17. Lane, M.A., Chen, A.C., Roman, S.D., Derguini, F. Gudas, L.J. (1999) Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells. Proc Natl Acad Sci USA 96 : 13524 13529.
18. Lin, T., Chao, C., Saito, S., Mazur, S.J., Murphy, M.E., Appella, E Xu, Y. (2005) p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 7 : 165 171.
19. Livingston, T., Eberhardt, D., Edwards, J.L. Godkin, J. (2004) Retinol improves bovine embryonic development in vitro. Reprod Biol Endocrinol 21 : 83 90.
20. Loh, Y.H., Wu, Q., Chew, J.L., Vega, V.B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., Wong, K.Y., Sung, K.W., Lee, C.W., Zhao, X.D., Chiu, K.P., Lipovich, L., Kuznetsov, V.A., Robson, P., Stanton, L.W., Wei, C.L., Ruan, Y., Lim, B. Ng, H.H. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38 : 431 440.
21. Martin, G. (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78 : 7634 7638.
22. Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Maruyama, M., Maeda, M. Yamanaka, S. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113 : 631 642.
23. Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Scholer, H. Smith, A. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95 : 379 391.
24. Pesce, M. Scholer, H.R. (2001) Oct-4: gatekeeper in the beginnings of mammalian evelopment. Stem Cells 19 : 271 278.
25. Pereira, L., Yi, F. Merr, B.J. (2006) Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol 26 : 7479 7491.
26. Piestun, D., Kochupurakkal, B.S., Jacob-Hirsch, J., Zeligson, S., Koudritsky, M., Domany, E., Amariglio, N., Rechavi, G. Givol, D. (2006) Nanog transforms NIH3T3 cells and targets cell-type restricted genes. Biochem Biophys Res Commun 343 : 279 285.
27. Robertson, E.J. (1987) Teratocarcinoma and embryonic stem cells: a practical approach. In : Robertson E.J. ed. Embryo derived cell lines. IRL press, McLean, VA, pp 71 112.
28. Rodda, D.J., Chew, J.L., Lim, L.H., Loh, Y.H., Wang, B., Ng, H.H. Robson, P. (2005) Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem 280 : 24731 24737.
29. Ross, S.A., McCaffery, P.J., Drager, U.C. DeLuca, L.M. (2000) Retinoids in embryonal development. Physiol Rev 80 : 1021 1054.
30. Saito, S., Liu, B. Yokoyama, K. (2004) Animal embryonic stem (ES) cells: self-renewal, pluripotency, transgenesis and nuclear transfer. Hum Cell 17 : 107 115.
31. Smith, A.G. (2001) Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 17 : 435 462.
32. Smith, A.G., Heath, J.K., Donaldson, D.D., Wong, G.G., Moreau, J., Stahl, M. Rogers, D. (1988) Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336 : 688 690.
33. Smith, P.D. Crompton, M.R. (1998) Expression of v-src in mammary epithelial cells induces transcription via STAT3. Biochem J 331 : 381 385.
34. Stewart, C.L., Kaspar, P., Brunet, L.J., Bhatt, H., Gadi, I., Kontgen, F. Abbondanzo, S.J. (1992) Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359 : 76 79.
35. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S. Jones, J.M. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282 : 1145 1147.
36. Wald, G. (1968) The molecular basis of visual excitation. Nature 219 : 800 807.
37. Wilder, P.J., Kelly, D., Brigman, K., Peterson, C.L., Nowling, T., Gao, Q.S., McComb, R.D., Capecchi, M.R. Rizzino, A. (1997) Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol 192 : 614 629.
38. Williams, R.L., Hilton, D.J., Pease, S., Willson, T.A., Stewart, C.L., Gearing, D.P., Wagner, E.F., Metcalf, D., Nicola, N.A. Gough, N.M. (1988) Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336 : 684 687.
39. Ying, Q.L., Nichols, J., Chambers, I. Smith, A. (2003) BMP ind;uction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115 : 281 292.
40. Yasuda, S.Y., Tsuneyoshi, N., Sumi, T., Hasegawa, K., Nakatsuji, N. Suemori, H. (2006) Nanog maintains self-renewal of primate ES cells in the absence of feeder layer. Genes Cells 11 : 1115 1123.
41. Yuan, H., Corbi, N., Basilico, C. Dailey, L. (1995) Developmental- specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9 : 2635 2645.
42. Zhang, J., Wang, X., Chen, B., Suo, G., Zhao, Y., Duan, Z. Dai, J. (2005) Expression of Nanog gene promotes NIH3T3 cell proliferation. Biochem Biophys Res Commun. 338 : 1098 1102.
43. Zhao, D., McCaffery, P., Ivins, K.J., Neve, R.L., Hogan, P., Chin, W.W. Drager, U.C. (1996) Molecular identification of a major retinoic-acid- synthesizing enzyme, a retinaldehyde-specific dehydrogenase. Eur J Biochem 240 : 15 22.
44. Zile, M.H. (2001) Function of vitamin A in vertebrate embryonic development. J Nutr 131 : 705 708. [Review].