Some new acyclic nucleotide analogues as antiviral prodrugs: Synthesis and bioactivities in vitro

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6350-6353

  Tang, Yan bo ^a   Peng, Zong gen ^a   Liu, Zong ying ^a   Li, Yan ping ^a   Jiang, Jian dong ^a   Li, Zhuo rong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Antiviral; HBV; HIV 1; Nucleotide prodrugs

Indexed keywords

ADEFOVIR; ALLYL COMPOUND; ANTIVIRUS AGENT; BENZYL DERIVATIVE; EMTRICITABINE; ESTER DERIVATIVE; NUCLEOTIDE DERIVATIVE; PRODRUG; TENOFOVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CELLS, CULTURED; DRUG DESIGN; ESTERS; HEPATITIS B VIRUS; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOTIDES; PRODRUGS;

HEPATITIS B VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 35148826858     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.065     Document Type: Article

References (23)

1. Piperno A., Chiacchio M.A., Iannazzo D., and Romeo R. Curr. Med. Chem. 13 (2006) 3675
2. De Clercq E. Antiviral Res. 67 (2005) 56
3. De Clercq E. Biochem. Pharmacol. 73 (2007) 911
4. Holy A. Antiviral Res. 71 (2006) 248
5. Khandazhinskaya A., Yasko M., and Shirokova E. Curr. Med. Chem. 13 (2006) 2953
6. Deeks S.G., Barditch-Crovo P., Lietman P.S., Hwang F., Cundy K.C., Rooney J.F., Hellmann N.S., Safrin S., and Kahn J.O. Antimicrob. Agents Chemother. 42 (1998) 2380
7. Mulato A.S., and Cherrington J.M. Antiviral Res. 36 (1997) 91
8. Srinivas R.V., Robbins B.L., Connelly M.C., Gong Y.F., Bischofberger N., and Fridland A. Antimicrob. Agents Chemother. 37 (1993) 2247
9. Fu X., Jiang S., Li C., Xin J., Yang Y., and Ji R. Bioorg. Med. Chem. Lett. 17 (2007) 465
10. Ruiz J.C., Beadle J.R., Aldern K.A., Keith K.A., Hartline C.B., Kern E.R., and Hostetler K.Y. Antiviral Res. 75 (2007) 87
11. Meier C., Görbig U., Mürller C., and Balzarini J. J. Med. Chem. 48 (2005) 8079
12. Erion M.D., Reddy K.R., Boyer S.H., Matelich M.C., Gomez-Galeno J., Lemus R.H., Ugarkar B.G., Colby T.J., Schanzer J., and van Poelje P.D. J. Am. Chem. Soc. 126 (2004) 5154
13. Ballatore C., McGuigan C., De Clercq E., and Balzarini J. Bioorg. Med. Chem. Lett. 11 (2001) 1053
14. Holy A., Günter J., Dvořáková H., Masoji{dotless}́dková M., Andrei G., Snoeck R., Balzarini J., and De Clercq E. J. Med. Chem. 42 (1999) 2064
15. Benzaria S., Pélicano H., Johnson R., Maury G., Imbach J.-L., Aubertin A.-M., Obert G., and Gosselin G. J. Med. Chem. 39 (1996) 4958
16. Arimilli, M. N.; Lee, T. T. K.; Manes, L. V.; Munger, J. D. Jr.; Prisbe, E. J.; Schultze, L. M.; Kelly, D. E. WO 199904774.
17. Munger, J. D. Jr.; Rohloff, J. C.; Schultze, L. M. WO 1999005150.
18. Lee W.A., and Martin J.C. Antiviral Res. 71 (2006) 254
19. Robbins B.L., Srinivas R.V., Kim C., Bischofberger N., and Fridland A. Antimicrob. Agents Chemother. 42 (1998) 612
20. Holy A. Curr. Pharm. Des. 9 (2003) 2567
21. +.
22. Holy A., and Rosenberg I. Collect. Czech. Chem. Commun. 52 (1987) 2801
23. Holy A., and Rosenberg I. Collect. Czech. Chem. Commun. 52 (1987) 2775