One-time graded doses of vitamin A to weanling piglets enhance hepatic retinol but do not always prevent vitamin A deficiency

American Journal of Clinical Nutrition

Volumn 86, Issue 4, 2007, Pages 1045-1053

  Surles, Rebecca L ^a   Mills, Jordan P ^a   Valentine, Ashley R ^a   Tanumihardjo, Sherry A ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Department of Nutritional Sciences ^*  (United States)

Author keywords

Infant nutrition; Supplementation; Vitamin A status

Indexed keywords

DEHYDRORETINOL; RETINOL;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG LIVER LEVEL; MALE; NONHUMAN; PIGLET; RETINOL DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 35148818316     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/86.4.1045     Document Type: Article

References (46)

1. World Health Organization. Immunizations, vaccines, and biologicals. Vitamin A supplementation (updated May 2003). Internet: http://www.who.int/ vaccines/en/vitamina.shtml (accessed 9 September 2006).
2. Ross DA. Recommendations for vitamin A supplementation. J Nutr 2002;131(suppl):2902S-6S.
3. Wieringa FT, Dijkhuizen MA, West CE, Thurnham DI, Muhilal, Van der Meer Jos WN. Redistribution of vitamin A after iron supplementation in Indonesian infants. Am J Clin Nutr 2003;77:651-7.
4. Bahl R, Bhandari N, Wahed MA, Kumar GT, Bhan MK; WHO/CHD Immunization-Linked Vitamin A Group. Vitamin A supplementation of women postpartum and of their infants at immunization alters breast milk retinol and infant vitamin A status. J Nutr 2002;132:3243-8.
5. Rahman MM, Mahalanabis D, Wahed MA, Islam MA, Habte D. Administration of 25,000 IU vitamin A doses at routine immunisation in young infants. Eur J Clin Nutr 1995;49:439-45.
6. Sommer A, Davidson FR. Assessment and control of vitamin A deficiency: the Annecy accords. J Nutr 2002;132(suppl):2845S-50S.
7. Baqui AH, de Francisco A, Arifeen SE, Siddique AK, Sack RB. Bulging fontanelle after supplementation with 25,000 IU of vitamin A in infancy using immunization contacts. Acta Paediatr 1995;84:863-6.
8. Malaba LC, Iliff PJ, Nathoo KJ, et al. Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. Am J Clin Nutr 2005;81:454-60.
9. West KP Jr, Katz J, Shrestha SR, et al. Mortality of infants <6 mo of age supplemented with vitamin A: a randomized, double-masked trial in Nepal. Am J Clin Nutr 1995;62:143-8.
10. WHO/CHD Immunization-Linked Vitamin A Supplementation Study Group. Randomized trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. Lancet 1998;352:1257-63.
11. Rahmathullah L, Tielsch JM, Thulasiraj RD, et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ 2003;327:254-9.
12. Humphrey JH, Agoestina T, Wu L, et al. Impact on neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr 1996;128:489-96.
13. Haskell M, Handelman G, Peerson J, et al. Assessment of vitamin A status by the deuterated-retinol-dilution technique and comparison with hepatic vitamin A concentration in Bangladeshi surgical patients. Am J Clin Nutr 1997;66:67-74.
14. Tanumihardjo SA. Assessing vitamin A status: past, present and future. J Nutr 2004;134(suppl):290S-3S.
15. Vitamin A Tracer Task Force. Appropriate uses of vitamin A tracer (stable isotope) methodology. Washington, DC: ILSI Human Nutrition Institute, 2004.
16. Penniston KL, Valentine AR, Tanumihardjo SA. A theoretical increase in infants' hepatic vitamin A is realized using a supplemented lactating sow model. J Nutr 2003;133:1139-42.
17. Penniston KL, Tanumihardjo SA. Elevated serum concentrations of β-glucuronide metabolites and 4-oxoretinol in lactating sows after treatment with vitamin A: a model for evaluating supplementation in lactating women. Am J Clin Nutr 2005;81:851-8.
18. Valentine AR, Tanumihardjo SA. One-time vitamin A supplementation of lactating sows enhances hepatic retinol in their offspring independent of dose size. Am J Clin Nutr 2005;81:427-33.
19. Valentine AR, Tanumihardjo SA. Adjustments to the modified relative dose response (MRDR) test for assessment of vitamin A status minimize the blood volume used in piglets. J Nutr 2004;134:1186 -92.
20. Surles RL, Li J, Tanumihardjo SA. The modified-relative-dose-response values in serum and milk are positively correlated over time in lactating sows with adequate vitamin A status. J Nutr 2006;136:939-45.
21. Darroch CS. Vitamin A in swine nutrition. In: Lewis AJ, Southern LL, eds. Swine nutrition. 2nd ed. Boca Raton, FL:CRC Press, 2001:263-80.
22. Book SA, Bustad LK. The fetal and neonatal pig in biomedical research. J Anim Sci 1974;38:997-1002.
23. Mount LE. The climatic physiology of the pig. London, United Kingdom: Edward Arnold Ltd, 1968.
24. National Center for Chronic Disease Prevention and Health Promotion (last updated 2000). Internet: www.cdc.gov/growthcharts (accessed 22 September 2006).
25. Benn CS, Martins C, Rodrigues A, Jensen H, Lisse IM, Aaby P. Randomised study of effect of different doses of vitamin A on childhood morbidity and mortality. BMJ 2005;331:1428-32.
26. Semba RD, Munasir Z, Akib A, et al. Integration of vitamin A supplementation with the Expanded Programme on Immunization: lack of impact on morbidity or infant growth. Acta Paediatr 2001;90:1107-11.
27. Haskell MJ, Pandey P, Graham JM, Peerson JM, Shrestha RK, Brown KH. Recovery from impaired dark adaptation in nightblind pregnant Nepali women who receive small daily doses of vitamin A as amaranth leaves, carrots, goat liver, vitamin A-fortified rice, or retinyl palmitate. Am J Clin Nutr 2005;81:461-71.
28. Katz J, West KP Jr, Khatry SK, et al. Maternal low-dose vitamin A or β-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal. Am J Clin Nutr 2000;71:1570-6.
29. Schmidt MK, Muslimatun S, West CE, Schultink W, Hautvast JGAJ. Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants. Br J Nutr 2001;86:607-15.
30. Suharno D, West CE, Muhilal, Karyadi D, Hautvast JGAJ. Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet 1993;342:1325-8.
31. Van den Broek NR, White SA, Flowers C, et al. Randomised trial of vitamin A supplementation in pregnant women in rural Malawi found to be anaemic on screening by HemoCue. BJOG 2006;113:569-76.
32. Tanumihardjo SA. Vitamin A and iron status are improved by vitamin A and iron supplementation in pregnant Indonesian women. J Nutr 2002;132:1909-12.
33. Mills JP, Terasawa E, Tanumihardjo SA. Excessive preformed vitamin A intake by mothers amplifies early fetal liver retinyl ester storage in captive Old World monkeys. Comp Med (in press).
34. Paik J, Vogel S, Quadro L, et al. Vitamin A: overlapping delivery pathways to tissues from the circulation. J Nutr 2004;134(suppl):276S-80S.
35. Humphrey JH, West KP Jr, Muhilal, See LC, Natadisastra G, Sommer A. Apriming dose of oral vitamin A given to preschool children may extend protection conferred by subsequent large dose of vitamin A. J Nutr 1993;123:1363-9.
36. Tchum SK, Tanumihardjo SA, Newton S, et al. Evaluation of vitamin A supplementation regimens in Ghanaian postpartum mothers using the modified-relative-dose-response test. Am J Clin Nutr 2006;84:1344-9.
37. Green MH, Green JB, Lewis KC. Variation in retinol utilization rate with vitamin A status in the rat. J Nutr 1987;117:694-703.
38. Davis CR, Jing H, Howe JA, Rocheford T, Tanumihardjo SA. Comparing the vitamin A bioefficacy of β-cryptoxanthin to β-carotene from supplements and maize in Mongolian gerbils. FASEB J 2007;21:A351 (abstr).
39. Idindili B, Masanja H, Urassa H, et al. Randomized controlled safety and efficacy trial of 2 vitamin A supplementation schedules in Tanzanian infants. Am J Clin Nutr 2007;85:1312-7.
40. Stephensen CB. Vitamin A, infection, and immune function. Annu Rev Nutr 2001;21:167-92.
41. Iliff PJ, Humphrey JH, Mahomva AI, et al. Tolerance of large doses of vitamin A given to mothers and their babies shortly after delivery. Nutr Res 1999;19:1437-46.
42. Humphrey JH, Agoestina T, Juliana A, et al. Neonatal vitamin A supplementation: effect on development and growth at 3 y of age. Am J Clin Nutr 1998;68:109-17.
43. Humphrey JH, Iliff PJ, Marinda ET, et al. Effects of a single large dose of vitamin A, given during the postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality J Infect Dis 2006;193:756-9.
44. Howe JA, Tanumihardjo SA. Carotenoid-biofortified maize maintains adequate vitamin A status in Mongolian gerbils. J Nutr 2006;136:2562-7.
45. Howe JA, Tanumihardjo SA. Evaluation of analytical methods for carotenoid extraction from biofortified maize (Zea mays sp.). J Ag Food Chem 2006;54:7992-7.
46. van Jaarsveld PJ, Faber M, Tanumihardjo SA, Nestel P, Lombard CJ, Benade AJ. β-Carotene-rich orange-fleshed sweet potato improves the vitamin A status of primary school children assessed with the modified-relative-dose- response test. Am J Clin Nutr 2005;81:1080-7.