메뉴 건너뛰기




Volumn 21, Issue 11, 2007, Pages 957-965

Rivastigmine transdermal patch: In the treatment of dementia of the Alzheimer's type

Author keywords

Adis Drug Profiles; Alzheimer's disease; Antidementias, general; Cholinesterase inhibitors, general; Rivastigmine, general; Transdermal

Indexed keywords

ANTACID AGENT; ANTIANGINA PECTORIS AGENT; ANTIDIABETIC AGENT; ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETHANECHOL; CALCIUM CHANNEL BLOCKING AGENT; DIAZEPAM; DIGOXIN; DRUG METABOLITE; ESTROGEN; FLUOXETINE; MEMANTINE; NAP 226 90; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; RIVASTIGMINE; SALICYLIC ACID DERIVATIVE; SUXAMETHONIUM; UNCLASSIFIED DRUG; WARFARIN;

EID: 35048895236     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200721110-00007     Document Type: Review
Times cited : (14)

References (30)
  • 1
    • 33845760457 scopus 로고    scopus 로고
    • The primary care of Alzheimer disease
    • Dec;
    • Rubin CD. The primary care of Alzheimer disease. Am J Med Sci 2006 Dec; 332 (6): 314-33
    • (2006) Am J Med Sci , vol.332 , Issue.6 , pp. 314-333
    • Rubin, C.D.1
  • 2
    • 0034643928 scopus 로고    scopus 로고
    • Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group
    • Lobo A, Launer LJ, Fratiglioni L, et al. Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000; 54 Suppl. 5: S4-9
    • (2000) Neurology , vol.54 , Issue.SUPPL. 5
    • Lobo, A.1    Launer, L.J.2    Fratiglioni, L.3
  • 3
    • 0038308843 scopus 로고    scopus 로고
    • The magnitude of dementia occurrence in the world
    • Apr-Jun;
    • Wimo A, Winblad B, Aguero-Torres H, et al. The magnitude of dementia occurrence in the world. Alzheimer Dis Assoc Disord 2003 Apr-Jun; 17 (2): 63-7
    • (2003) Alzheimer Dis Assoc Disord , vol.17 , Issue.2 , pp. 63-67
    • Wimo, A.1    Winblad, B.2    Aguero-Torres, H.3
  • 5
    • 0033632077 scopus 로고    scopus 로고
    • Practice guidelines for the diagnosis and treatment of Alzheimer's disease in a managed care setting: Part II. Pharmacologic therapy. Alzheimer's Disease Managed Care Advisory Council
    • Jan;
    • Fillit H, Cummings J. Practice guidelines for the diagnosis and treatment of Alzheimer's disease in a managed care setting: part II. Pharmacologic therapy. Alzheimer's Disease Managed Care Advisory Council. Manag Care Interface 2000 Jan; 13 (1): 51-6
    • (2000) Manag Care Interface , vol.13 , Issue.1 , pp. 51-56
    • Fillit, H.1    Cummings, J.2
  • 6
    • 0033985927 scopus 로고    scopus 로고
    • Rivastigmine, a new-generation cholinesterase inhib-itor for the treatment of Alzheimer's disease
    • Jan;
    • Jann MW. Rivastigmine, a new-generation cholinesterase inhib-itor for the treatment of Alzheimer's disease. Pharmacotherapy 2000 Jan; 20 (1): 1-12
    • (2000) Pharmacotherapy , vol.20 , Issue.1 , pp. 1-12
    • Jann, M.W.1
  • 7
    • 1442286389 scopus 로고    scopus 로고
    • Management of mild to moderate Alzheimer disease
    • Plosker GL, Keating GM. Management of mild to moderate Alzheimer disease. Dis Manage Health Outcomes 2004; 12 (1): 55-72
    • (2004) Dis Manage Health Outcomes , vol.12 , Issue.1 , pp. 55-72
    • Plosker, G.L.1    Keating, G.M.2
  • 8
    • 33745843336 scopus 로고    scopus 로고
    • Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease
    • Jul;
    • Lyketsos CG, Colenda CC, Beck C, et al. Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. Am J Geriatr Psychiatry 2006 Jul; 14 (7): 561-73
    • (2006) Am J Geriatr Psychiatry , vol.14 , Issue.7 , pp. 561-573
    • Lyketsos, C.G.1    Colenda, C.C.2    Beck, C.3
  • 9
    • 6944250119 scopus 로고    scopus 로고
    • Long-term cholinesterase inhibitor treatment of Alzheimer's disease
    • Johannsen P. Long-term cholinesterase inhibitor treatment of Alzheimer's disease. CNS Drugs 2004; 18 (12): 757-68
    • (2004) CNS Drugs , vol.18 , Issue.12 , pp. 757-768
    • Johannsen, P.1
  • 10
    • 0037096921 scopus 로고    scopus 로고
    • Cummings JL, Frank JC, Cherry D, et al. Guidelines for managing Alzheimer's disease: part II. Treatment. Am Fam Physician 2002 Jun 15; 65 (12): 2525-34
    • Cummings JL, Frank JC, Cherry D, et al. Guidelines for managing Alzheimer's disease: part II. Treatment. Am Fam Physician 2002 Jun 15; 65 (12): 2525-34
  • 11
    • 35048904636 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence, online, September 2007. Available from URL:, Accessed September 27
    • National Institute for Health and Clinical Excellence. Donepezil, galantamine, rivastigmine (review) and memantine for the treatment of Alzheimer's disease (amended) [online]. September 2007. Available from URL: http://guidance. nice.org.uk/TA111/guidance/pdf/English/download.dspx [Accessed 2007 September 27]
    • (2007) Donepezil, galantamine, rivastigmine (review) and memantine for the treatment of Alzheimer's disease (amended)
  • 12
    • 35048879789 scopus 로고    scopus 로고
    • European Medicines Agency. Exelon® 1.5, 3.0, 4.5 and 6.0 hard capsules: summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/humandocs/PDFs/ EPAR/Exelon/H-169-PI-en.pdf [Accessed 2007 May 10]
    • European Medicines Agency. Exelon® 1.5, 3.0, 4.5 and 6.0 hard capsules: summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/humandocs/PDFs/ EPAR/Exelon/H-169-PI-en.pdf [Accessed 2007 May 10]
  • 13
    • 35048887628 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation, US prescribing information [online, Available from URL:, Accessed May 10
    • Novartis Pharmaceuticals Corporation. Exelon® (rivastigmine tartrate) capsules and oral solution: US prescribing information [online]. Available from URL: http://www.pharma.us. novartis.com/product/pi/pdf/exelon.pdf [Accessed 2007 May 10]
    • (2007) Exelon® (rivastigmine tartrate) capsules and oral solution
  • 14
    • 0037532679 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for the treatment of Alzheimer's disease: Getting on and staying on
    • Apr;
    • Grossberg GT. Cholinesterase inhibitors for the treatment of Alzheimer's disease: getting on and staying on. Curr Ther Res 2003 Apr; 64 (4): 216-35
    • (2003) Curr Ther Res , vol.64 , Issue.4 , pp. 216-235
    • Grossberg, G.T.1
  • 16
    • 33745894355 scopus 로고    scopus 로고
    • Transdermal treatment options for neurological disorders: Impact on the elderly
    • Priano L, Gasco MR, Mauro A. Transdermal treatment options for neurological disorders: impact on the elderly. Drugs Aging 2006; 23 (5): 357-75
    • (2006) Drugs Aging , vol.23 , Issue.5 , pp. 357-375
    • Priano, L.1    Gasco, M.R.2    Mauro, A.3
  • 17
    • 35048889580 scopus 로고    scopus 로고
    • Exelon® 4.6 and 9.5 mg/24 hours trandermal patch: summary of product characteristics. Horsham: Novartis Europharm Limited, 2007.
    • Exelon® 4.6 and 9.5 mg/24 hours trandermal patch: summary of product characteristics. Horsham: Novartis Europharm Limited, 2007.
  • 18
    • 35048893439 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation, US prescribing information [online, Available from URL:, Accessed Aug 7
    • Novartis Pharmaceuticals Corporation. Exelon® patch (rivastigmine transdermal system): US prescribing information [online]. Available from URL: http://www.pharma.us.novartis. com/product/pi/pdf/exelonpatch.pdf [Accessed 2007 Aug 7]
    • (2007) Exelon® patch (rivastigmine transdermal system)
  • 19
    • 26944456359 scopus 로고    scopus 로고
    • Rivastigmine is a potent inhibitor of acetyl- and butyrylcholinesterase in Alzheimer's plaques and tangles
    • Oct 26;
    • Eskander MF, Nagykery NG, Leung EY, et al. Rivastigmine is a potent inhibitor of acetyl- and butyrylcholinesterase in Alzheimer's plaques and tangles. Brain Res 2005 Oct 26; 1060 (1-2): 144-52
    • (2005) Brain Res , vol.1060 , Issue.1-2 , pp. 144-152
    • Eskander, M.F.1    Nagykery, N.G.2    Leung, E.Y.3
  • 20
    • 32544459171 scopus 로고    scopus 로고
    • Transdermal rivastigmine treatment does not worsen impaired performance of complex motions in patients with Alzheimer's disease
    • Jan;
    • Muhlack S, Przuntek H, Müller T. Transdermal rivastigmine treatment does not worsen impaired performance of complex motions in patients with Alzheimer's disease. Pharmacopsychiatry 2006 Jan; 39 (1): 16-9
    • (2006) Pharmacopsychiatry , vol.39 , Issue.1 , pp. 16-19
    • Muhlack, S.1    Przuntek, H.2    Müller, T.3
  • 21
    • 0038308812 scopus 로고    scopus 로고
    • Inhibition of human cholinesterases by drugs used to treat Alzheimer disease
    • Darvesh S, Walsh R, Kumar R, et al. Inhibition of human cholinesterases by drugs used to treat Alzheimer disease. Alzheimer Dis Assoc Disord 2003; 17 (2): 117-26
    • (2003) Alzheimer Dis Assoc Disord , vol.17 , Issue.2 , pp. 117-126
    • Darvesh, S.1    Walsh, R.2    Kumar, R.3
  • 22
    • 0042286681 scopus 로고    scopus 로고
    • Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain
    • Aug;
    • Rakonczay Z. Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain. Acta Biol Hung 2003 Aug; 54 (2): 183-9
    • (2003) Acta Biol Hung , vol.54 , Issue.2 , pp. 183-189
    • Rakonczay, Z.1
  • 23
    • 0035661483 scopus 로고    scopus 로고
    • A new therapeutic target in Alzheimer's disease treatment: Attention to butyrylcholinesterase
    • Greig NH, Utsuki T, Yu QS, et al. A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase. Curr Med Res Opin 2001; 17 (3): 159-65
    • (2001) Curr Med Res Opin , vol.17 , Issue.3 , pp. 159-165
    • Greig, N.H.1    Utsuki, T.2    Yu, Q.S.3
  • 24
    • 0034113018 scopus 로고    scopus 로고
    • Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications
    • Mar;
    • Grossberg GT, Stahelin HB, Messina JC, et al. Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications. Int J Geriatr Psychiatry 2000 Mar; 15 (3): 242-7
    • (2000) Int J Geriatr Psychiatry , vol.15 , Issue.3 , pp. 242-247
    • Grossberg, G.T.1    Stahelin, H.B.2    Messina, J.C.3
  • 25
    • 33947522151 scopus 로고    scopus 로고
    • Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: Relative effects of body site application
    • Apr;
    • Lefèvre G, Sedek G, Huang HLA, et al. Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application. J Clin Pharmacol 2007 Apr; 47 (4): 471-8
    • (2007) J Clin Pharmacol , vol.47 , Issue.4 , pp. 471-478
    • Lefèvre, G.1    Sedek, G.2    Huang, H.L.A.3
  • 26
    • 34249683625 scopus 로고    scopus 로고
    • A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease: Rivastigmine patch versus capsule
    • May;
    • Winblad B, Cummings J, Andreasen N, et al. A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease: rivastigmine patch versus capsule. Int J Geriatr Psychiatry 2007 May; 22 (5): 456-67
    • (2007) Int J Geriatr Psychiatry , vol.22 , Issue.5 , pp. 456-467
    • Winblad, B.1    Cummings, J.2    Andreasen, N.3
  • 27
    • 34249705681 scopus 로고    scopus 로고
    • Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease
    • May;
    • Winblad B, Kawata AK, Beusterien KM, et al. Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease. Int J Geriatr Psychiatry 2007 May; 22 (5): 485-91
    • (2007) Int J Geriatr Psychiatry , vol.22 , Issue.5 , pp. 485-491
    • Winblad, B.1    Kawata, A.K.2    Beusterien, K.M.3
  • 28
    • 0004235298 scopus 로고
    • American Psychiatric Association, 4th ed. Washington, DC: American Psychiatric Association
    • American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994
    • (1994) Diagnostic and statistical manual of mental disorders
  • 29
    • 34547634202 scopus 로고    scopus 로고
    • IDEAL: A 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease
    • Jul 24;
    • Winblad B, Grossberg G, Frolich L, et al. IDEAL: a 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease. Neurology 2007 Jul 24; 69 Suppl. 1: S14-22
    • (2007) Neurology , vol.69 , Issue.SUPPL. 1
    • Winblad, B.1    Grossberg, G.2    Frolich, L.3
  • 30
    • 35048892979 scopus 로고    scopus 로고
    • Data on file, Novartis Europharm Ltd, 2007
    • Data on file, Novartis Europharm Ltd, 2007


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.