Adapalene pretreatment increases follicular penetration of clindamycin: In vitro and in vivo studies

Indian Journal of Dermatology, Venereology and Leprology

Volumn 73, Issue 5, 2007, Pages 326-329

  Jain, Gaurav ^a,b   Ahmed, Farhan ^a  

^a HAMDARD UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Adapalene; Clindamycin phosphate; Follicular penetration; Pilosebaceous units

Indexed keywords

ADAPALENE; CLINDAMYCIN PHOSPHATE;

ADULT; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIARRHEA; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENTIATION; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LIQUID SCINTILLATION COUNTING; MONOTHERAPY; NONHUMAN; NORMAL HUMAN; PSEUDOMEMBRANOUS COLITIS; QUANTITATIVE ANALYSIS; RAT; SKIN CULTURE; UNSPECIFIED SIDE EFFECT;

EID: 35048868798     PISSN: 03786323     EISSN: None     Source Type: Journal    
DOI: 10.4103/0378-6323.34010     Document Type: Article

References (11)

1. Cunliffe WJ, Caputo R, Dreno B, Forstrom L, Heenen M, Orfanos CE, et al. Efficacy and safety comparisons of adapalene (CD271) gel and tretinoin gel in the topical treatment of acne vulgaris. A European multicentre trial. J Dermatol Treat 1997;8:173-8.
2. Thiboutot D. New treatments and therapeutic strategies for acne. Arch Fam Med 2000;9:179-87.
3. Dreno B. Topical antibacterial therapy for acne vulgaris. Drugs 2004;64:2389-97.
4. Ellis CN, Gammon WR, Stone DZ, Heezen-Wehner JL. A comparison of Cleocin T Solution, Cleocin T Gel, and placebo in the treatment of acne vulgaris. Cutis 1998;42:245-7.
5. Gollnick HP, Krautheim A. Topical treatment in acne: Current status and future aspects. Dermatology 2003;206:29-36.
6. Waugh J, Noble S, Scott LJ. Adapalene: A review of its use in the treatment of acne vulgaris. Drugs 2004;64:1465-78.
7. Toyoda M, Morohashi M. An overview of topical antibiotics for acne treatment. Dermatology 1998;196:130-4.
8. Akhavan A, Bershad S. Topical acne drugs: Review of clinical properties, systemic exposure and safety. Am J Clin Dermatol 2003;4:473-92.
9. van Hoogdalem EJ. Transdermal absorption of topical anti-acne agents in man: Review of clinical pharmacokinetic data. J Eur Acad Dermatol Venereol 1998;11:S13-9.
10. Meidan VM, Bonner MC, Michniak BB. Transfollicular drug delivery-is it a reality? Int J Pharm 2005;306:1-14.
11. Shroot B, Michel S. Pharmacology and chemistry of adapalene. J Am Acad Dermatol 1997;36:S96-103.