Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data

Journal of the European Academy of Dermatology and Venereology

Volumn 11, Issue SUPPL. 1, 1998, Pages

  Van Hoogdalem, E J ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Acne; Clinical pharmacokinetics; Review; Transdermal absorption

Indexed keywords

4 OXOISOTRETINOIN; ADAPALENE; ANTIANDROGEN; ANTIBIOTIC AGENT; AZELAIC ACID; BENZOYL PEROXIDE; CLINDAMYCIN; CLINDAMYCIN PHOSPHATE; CLINDAMYCIN PLUS RETINOIC ACID; CYOCTOL; CYPROTERONE ACETATE; ERYTHROMYCIN; ISOTRETINOIN; RETINOIC ACID; RETINOID; RETINOVA; UNCLASSIFIED DRUG; ZINC;

ACNE VULGARIS; CLINICAL TRIAL; CONFERENCE PAPER; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG PENETRATION; DRUG UPTAKE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; PRIORITY JOURNAL; PSEUDOMEMBRANOUS COLITIS; SKIN ABSORPTION; TERATOGENICITY; TOPICAL DRUG ADMINISTRATION;

EID: 0032438642     PISSN: 09269959     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1468-3083.1998.tb00902.x     Document Type: Conference Paper

References (27)

1. Ebling FJG, Cunliffe WJ. The sebaceous glands. In: Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL editors. Textbook of Dermatology, Part 3, 4th edn. Oxford: Blackwell, 1996:1913-1936.
2. Webster GF. Acne. Curr Probl Dermatol 1996;8:241-268.
3. Latriano L, Tzimas G, Wong F, Wills RJ. The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use, J Am Acad Dermatol 1997;36:S37-S46.
4. van Hoogdalem EJ, Baven ALM, Spiegel-Melsen I, Terpstra IJ. Transdermal absorption of clindamycin and tretinoin from topically applied anti-acne formulations in man. Biopharm Drug Disp, in press.
5. Buchan P, Eckhoff C, Caron D, Nau H, Shroot B, Schaefer H. Repeated topical administration of all-trans-retinoic acid and plasma levels of retinoic acids in humans, J Am Acad Dermatol 1994;30:428-434.
6. Nau H. Embryotoxicity and teratogenicity of topical retinoic acid, Skin Pharmacol 1993;6(Suppl 1):35-44.
7. Franz TJ, Lehman PA. Systemic absorption of retinoic acid, J Toxicol Cut Ocular Toxicol 1989;9:517-524.
8. Kligman AM. Current status of topical tretinoin in the treatment of photoaged skin, Drugs Aging 1992;2:7-13.
9. Jensen BJ, McGann LA, Kachevsky V, Franz TJ. The negligible systemic availability of retinoids with multiple and excessive topical application of isotretinoin 0.05% gel (Isotrex) in patients with acne vulgaris, J Am Acad Dermatol 1991;24:425-428.
10. Chen C, Jensen BK, Mistry G, Wyss R, Zultak M, Patel IH, Rakhit AK. Negligible systemic absorption of topical isotretinoin cream: implications for teratogenicity, J Clin Pharmacol 1997;37:279-284.
11. Voron DA. Systemic absorption of topical clindamycin, Arch Dermatol 1978;114:798.
12. Milstone EB, McDonald AJ, Scholhamer CF. Pseudomembranous colitis after topical application of clindamycin, Arch Dermatol 1981;117:154-155.
13. Barza M, Goldstein JA, Kane A, Feingold DS, Pochi PE. Systemic absorption of clindamycin hydrochloride after topical application, J Am Acad Dermatol 1982;7:208-214.
14. Eller MG, Smith RB, Phillips JP. Absorption kinetics of topical clindamycin preparations, Biopharm Drug Disp 1989;10:505-512.
15. DeHaan RM, Metzler CM, Schellenberg D, Vandenbosch WD. Pharmacokinetic studies of clindamycin phosphate. J Clin Pharmacol 1973;190-209.
16. Siegle RJ, Fekety R, Sarbone PD, Finch RN, Deery HG, Voorhees JJ. Effects of topical clindamycin on intestinal microflora in patients with acne, J Am Acad Dermatol 1986;15:180-185.
17. Borglund E, Hägermark O, Nord CE. Impact of topical clindamycin and systemic tetracycline on the skin and colon microflora in patients with acne vulgaris, Scand J Infect Dis 1984;43(Suppl):76-81.
18. Rietschel RL, Duncan SH. Clindamycin phosphate used in combination with tretinoin in the treatment of acne, Int J Dermatol 1983;22:41-43.
19. Parry MF, Rha C-K. Pseudomembranous colitis caused by topical clindamycin phosphate, Arch Dermatol 1986;122:583-584.
20. Illel B. Formulation for transfollicular drug administration: some recent advances, Crit Rev Ther Drug Carr Syst 1997;14:207-219.
21. van Hoogdalem FJ, Terpstra IJ, Baven ALM. Evaluation of the effect of zinc acetate on the stratum corneum penetration kinetics of erythromycin in healthy male volunteers, Skin Pharmacol 1996;9:104-110.
22. Wester RC, Patel R, Nacht S, Leyden J, Melendres J, Maibach H. Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy, J Am Acad Dermatol 1991;24:720-726.
23. Yeung D, Nacht S, Bucks D, Maibach H. Benzoyl peroxide: percutaneous penetration and metabolic disposition, II, Effect of concentration. J Am Acad Dermatol 1983;9:920-924.
24. Gollnick H. Azelaic acid - pharmacology, toxicology and mechanism of action on keratinization in vitro and in vivo, J Dermatol Treat 1993;4(Suppl 1):S3-S7.
25. Rolland A, Wagner N, Chatelus A, Shroot B, Schaefer H. Site-specific drug delivery to pilosebaceous structures using polymeric microspheres, Pharmacol Res 1993;10:1738-1744.
26. de Zeeuw RA, Herder RE, Wiechers JW, Drenth BFH. Metabolic conversion of cyoctol during skin passage in humans, Pharmacol Res 1990;7:638-643.
27. Kotwas J, Schaefer H, Zesch A. Zur Verfügbarkeit von Wirkstoffen an und in der Haut, Arzneim-Forsch/Drug Res 1979;29:562-568.