Increased visceral adipose tissue rather than BMI as a risk factor for dementia

Age and Ageing

Volumn 36, Issue 5, 2007, Pages 488-491

  Cereda, Emanuele ^a   Sansone, Valeria ^a   Meola, Giovanni ^a   Malavazos, Alexis Elias ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Body mass index (BMI); Cognitive decline; Dementia; Elderly; Visceral adipose tissue

Indexed keywords

ADIPOCYTOKINE; ANTIHYPERTENSIVE AGENT; C REACTIVE PROTEIN; CHEMOKINE; FATTY ACID; GLUCOSE; HORMONE; INSULIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; VISFATIN;

ABDOMINAL SUBCUTANEOUS FAT; AGED; ALZHEIMER DISEASE; ANTHROPOMETRY; ATHEROSCLEROSIS; BLOOD PRESSURE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COGNITIVE DEFECT; DEMENTIA; DISEASE ASSOCIATION; DYSLIPIDEMIA; FEASIBILITY STUDY; HUMAN; HYPERTENSION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPOLYSIS; MULTIINFARCT DEMENTIA; NEUROCHEMISTRY; NOTE; OBESITY; PATHOPHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; RISK FACTOR; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

BODY MASS INDEX; DEMENTIA; HUMANS; INTRA-ABDOMINAL FAT; RISK FACTORS;

EID: 35048849371     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afm096     Document Type: Note

References (21)

1. Gorospe EC, Dave JK. The risk of dementia with increased body mass index: A systematic review. Age Ageing 2007; 36: 23-9.
2. Gustafson D. Adiposity indices and dementia. Lancet Neurol 2006; 5: 713-20.
3. Razay G, Vreugdenhil A, Wilcock G. Obesity, abdominal obesity and Alzheimer disease. Dement Geriatr Cogn Disord 2006; 22:173-6.
4. Luchsinger JA, Patel B, Tang MX, Schupf N, Mayeux R. Measures of adiposity and dementia risk in elderly persons. Arch Neurol 2007; 64: 392-8.
5. Decarli C. Vascular factors in dementia: An overview. J Neurol Sci 2004; 226: 19-23.
6. Wajchenberg BL. Subcutaneous -and visceral adipose tissue: Their relation to the metabolic syndrome. Endocr Rev 2000; 21: 697-738.
7. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881-7.
8. Schneider HJ, Glaestner H, Klotsche J et al. Accuracy of anthropometric indicators of obesity to predict cardiovascular risk. J Clin Endocrinol Metab 2007; 92: 589-94.
9. Kivipelto M, Ngandu T, Fratiglioni L, et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 2005; 62:1556-60.
10. Qiu C, von Strauss E, Fastbom J, Winblad B, Fratiglioni L. Low blood pressure and risk of dementia in the Kungsholmen project: A 6-year follow-up study. Arch Neurol 2003; 60:223-8.
11. Kuo HK, Jones RN, Milberg WP et al. Effect of blood pressure and diabetes mellitus on cognitive and physical functions in older adults: A longitudinal analysis of the advanced cognitive training for independent and vital elderly cohort. J Am Geriatr Soc 2005; 53: 1154-61.
12. Yaffe K, Kanaya A, Lindquist K et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 2004; 292: 2237-42.
13. Price GM, Uauy R, Breeze E, Bulpitt CJ, Fletcher AE. Weight, shape, and mortality risk in older persons: Elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death. Am J Clin Nutr 2006; 84: 449-60.
14. Jensen MD. Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model. Obesity (Silver Spring) 2006; 14(Suppl. 1): 20-4.
15. Patil S, Chan C. Palmitic and stearic fatty adds induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci Lett 2005; 384: 288-93.
16. Tilg H, Moschen AR. Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772-83.
17. Engelhart MJ, Geerlings MI, Meijer J et al. Inflammatory proteins in plasma and the risk of dementia: The Rotterdam study. Arch Neurol 2004; 61: 668-72.
18. Malavazos AE, Cereda E, Morricone L, Coman C, Corsi NM Ambrosi B. Monocyte chemoattractant protein 1: A possible link between visceral adipose tissue associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity. Eur J Endocrinol 2005; 153: 871-7.
19. Malavazos AE, Corsi W Ermetici F et al. Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity: Relationship with abdominal fat deposition. Nutr Metab Cardiovasc: Dis 2007; 17: 294-302.
20. Rosengren A, Skoog J, Gustafson D, Wilhelmsen L. Body mass index, other cardiovascular risk factors, and hospitalization for dementia. Arch Intem Med 2005; 165: 321-6.
21. Stewart R, Masaki K, Xue QL et al. A 32-year prospective study of change in body weight and incident dementia: The Honolulu-Asia Aging Study. Arch Neurol 2005; 62: 55-60.