Effect of resveratrol on function of HERG K+ channels

Chinese Pharmacological Bulletin

Volumn 23, Issue 7, 2007, Pages

  Zhao, Wen Xiao ^a   Qi, Zhi Ping ^a   Bai, Yun Long ^a   Zhang, Ying ^a   Zhao, Xue Ling ^a   Lü, Yan Jie ^a   Li, Bao Xin ^a   Yang, Bao Feng ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

HERG K+ channels; Patch clamp technique; Resveratrol

Indexed keywords

POTASSIUM CHANNEL HERG; RESVERATROL;

ARTICLE; DRUG EFFECT; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; KIDNEY CELL; PATCH CLAMP;

EID: 35048845204     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Jang M, Cai L, Udeani G O, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes[J]. Science, 1997,275(5297):218-20.
2. Fremont L. Biological effects of resveratrol[J]. Life Sci, 2000,66(8):663-73.
3. Zhang H Y, Xu C Q, Li H X, et al. The effect of resveratrol on arrhythmia and cardiac ischemia[J]. Chin Pharmacol Bull, 2006,22(3):383-4.
4. Busch A E, Eigenberger B, Jurkiewicz N K, et al. Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action[J]. Brit J Pharmacol, 1998,123(1):23-30.
5. Wang H Z, Yang B F, Luo D L, et al. Study the antiarrhythmic effects of the artemisinin[J]. Chin Pharmacol Bull, 1998,14(1):102.
6. Li B X, Yang B F, Zhou J, et al. Inhibitory effects of berberine on Ik1, Ik, and HERG channels of cardiac myocytes[J]. Acta Pharmacol Sin, 2001,22(2):125-31.
7. Li B X, Yang B F, Li Y R, et al. Study on the antiarrhythmic effect and mechanism of artemisinin[J]. Chin Pharmacol Bull. 1999,15(5):66-9.
8. Wang Z, Fermini B, Nattel S. Rapid and slow components of delayed rectifier current in human atrial myocytes[J]. Cardiovasc Res. 1994,28(10):1540-6.
9. Zhang S, Zhou Z, Gong Q, et al. Mechanism of block and identification of the verapamil binding domain to HERG potassium channels[J]. Circ Res, 1999,84(9):989-98.
10. Sanguinetti M C, Tristani-Firouzi M. hERG potassium channel and cardiac arrihythmia[J]. Nature, 2006,440(7083):463-9.
11. Yang B F, Shan H L, Gong D M, et al. Study on the best targets of antiarrhythmic drugs[J]. J Harbin Univ Commer(Nat Sci Ed), 2002,18(1):5-9.
12. + Channel gating[J]. Biophys J, 2000,79(1):231-46.