Alternative splicing in the dyslexia-associated gene KIAA0319

Mammalian Genome

Volumn 18, Issue 9, 2007, Pages 627-634

  Velayos Baeza, Antonio ^a   Toma, Claudio ^a   Da Roza, Stephanie ^a   Paracchini, Silvia ^a   Monaco, Anthony P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

5' UNTRANSLATED REGION; ADULT; ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; BRAIN; CHROMOSOME 6P; CONTROLLED STUDY; DYSLEXIA; EXON; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; KIAA0319 GENE; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BRAIN CHEMISTRY; CEREBRAL CORTEX; COMPUTATIONAL BIOLOGY; DYSLEXIA; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RATS;

RATTUS;

EID: 35048813966     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-007-9051-3     Document Type: Article

References (19)

1. Cope N, Harold D, Hill G, Moskvina V, Stevenson J, et al. (2005) Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. Am J Hum Genet 76:581-591
2. Fisher SE, Francks C (2006) Genes, cognition and dyslexia: learning to read the genome. Trends Cogn Sci 10:250-257
3. Francks C, Paracchini S, Smith SD, Richardson AJ, Scerri TS, et al. (2004) A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Am J Hum Genet 75:1046-1058
4. Galaburda AM, LoTurco J, Ramus F, Fitch RH, Rosen GD (2006) From genes to behavior in developmental dyslexia. Nat Neurosci 9:1213-1217
5. Ghashghaei HT, Lai C, Anton ES (2007) Neuronal migration in the adult brain: are we there yet? Nat Rev Neurosci 8:141-151
6. Guo J, Chen S, Huang C, Chen L, Studholme DJ, et al. (2004) MANSC: a seven-cysteine-containing domain present in animal membrane and extracellular proteins. Trends Biochem Sci 29:172-174
7. Habib M (2000) The neurological basis of developmental dyslexia: an overview and working hypothesis. Brain 123 Pt 12:2373-2399
8. Harold D, Paracchini S, Scerri T, Dennis M, Cope N, et al. (2006) Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Mol Psychiatry 11:1085-1091
9. Hughes TA (2006) Regulation of gene expression by alternative untranslated regions. Trends Genet 22:119-122
10. Ibraghimov-Beskrovnaya O, Bukanov NO, Donohue LC, Dackowski WR, Klinger KW, et al. (2000) Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1. Hum Mol Genet 9:1641-1649
11. Lejeune F, Maquat LE (2005) Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol 17:309-315
12. Londin ER, Meng H, Gruen JR (2003) A transcription map of the 6p22.3 reading disability locus identifying candidate genes. BMC Genomics 4:25
13. McGrath LM, Smith SD, Pennington BF (2006) Breakthroughs in the search for dyslexia candidate genes. Trends Mol Med 12:333-341
14. Mignone F, Gissi C, Liuni S, Pesole G (2002) Untranslated regions of mRNAs. Genome Biol 3, reviews0004
15. Ming GL, Song H (2005) Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 28:223-250
16. Paracchini S, Thomas A, Castro S, Lai C, Paramasivam M, et al. (2006) The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Hum Mol Genet 15:1659-1666
17. Stamm S, Ben-Ari S, Rafalska I, Tang Y, Zhang Z, et al. (2005) Function of alternative splicing. Gene 344:1-20
18. Wagner E, Lykke-Andersen J (2002) mRNA surveillance: the perfect persist. J Cell Sci 115:3033-3038
19. Williams J, O'Donovan MC (2006) The genetics of developmental dyslexia. Eur J Hum Genet 14:681-689