Depleting endogenous neurotrophin-3 enhances myelin formation in the Trembler-J mouse, a model of a peripheral neuropathy

Journal of Neuroscience Research

Volumn 85, Issue 13, 2007, Pages 2863-2869

  Liu, Ning ^a   Varma, Sushama ^a   Tsao, David ^a   Shooter, Eric M ^a   Tolwani, Ravi J ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Charcot Marie Tooth disease; Myelin; NT3 TrkC signaling; Therapy; Trembler J mouse

Indexed keywords

NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR;

ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; MOUSE; MYELIN SHEATH; MYELINATION; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NEUROLOGIC MUTANTS; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN P0 PROTEIN; MYELIN SHEATH; NEUROTROPHIN 3; ORGAN CULTURE TECHNIQUES; PERIPHERAL NERVOUS SYSTEM DISEASES; RECEPTOR, TRKC; S100 PROTEINS;

EID: 34948909103     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21388     Document Type: Article

References (26)

1. Alberghina M, Bernocchi G, Biggiogera M, Viola M, Karlsson JO, Manfredi-Romanini MG, Giuffrida AM. 1985. Synthesis of myelin proteins and ultrastructural investigations in regenerating rat sciatic nerve. J Neurosci Res 13:551-562.
2. Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV, Rosenthal A. 1991. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7:857-866.
3. Binder DK, Routbort MJ, Ryan TE, Yancopoulos GD, McNamara JO. 1999. Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. J Neurosci 19:1424-1436.
4. Chan JR, Cosgaya JM, Wu YJ, Shooter EM. 2001. Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci U S A 98:14661-14668.
5. NTR as a positive modulator of myelination. Science 298:1245-1248.
6. Friede RL, Samorajski T. 1967. Relation between the number of myelin lamellae and axon circumference in fibers of vagus and sciatic nerves of mice. J Comp Neurol 130:223-231.
7. Friede RL, Samorajski T. 1968. Myelin formation in the sciatic nerve of the rat. A quantitative electron microscopic, histochemical and radioautographic study. J Neuropathol Exp Neurol 27:546-570.
8. Garbay B, Heape AM, Sargueil F, Cassagne C. 2000. Myelin synthesis in the peripheral nervous system. Prog Neurobiol 61:267-304.
9. Hallbook F, Ibanez CF, Persson H. 1991. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6:845-858.
10. Henry EW, Cowen JS, Sidman RL. 1983. Comparison of Trembler and Trembler-J mouse phenotypes: varying severity of peripheral hypomyelination. J Neuropathol Exp Neurol 42:688-706.
11. Hildebrand C, Kocsis JD, Berglund S, Waxman SG. 1985. Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Res 358:163-170.
12. Hohn A, Leibrock J, Bailey K, Barde YA. 1990. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344:339-341.
13. Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P, Thoenen H, Barde YA. 1989. Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341:149-152.
14. Levi-Montalcini R. 1987. The nerve growth factor 35 years later. Science 237:1154-1162.
15. Lewin GR, Barde YA. 1996. Physiology of the neurotrophins. Annu Rev Neurosci 19:289-317.
16. Liu N, Varma S, Shooter EM, Tolwani RJ. 2005. Enhancement of Schwann cell myelin formation by K252a in the Trembler-J mouse dorsal root ganglion expiant culture. J Neurosci Res 79:310-317.
17. Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM, Yancopoulos GD. 1990. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5:501-509.
18. Meakin SO, Shooter EM. 1992. The nerve growth factor family of receptors. Trends Neurosci 15:323-331.
19. Notterpek L, Shooter EM, Snipes GJ. 1997. Upregulation of the endosomal-lysosomal pathway in the trembler-J neuropathy. J Neurosci 17:4190-4200.
20. Offenhauser N, Bohm-Matthaei R, Tsoulfas P, Parada L, Meyer M. 1995. Developmental regulation of full-length trkC in the rat sciatic nerve. Eur J Neurosci 7:917-925.
21. Passage E, Norreel JC, Noack-Fraissignes P, Sanguedolce V, Pizant J, Thirion X, Robaglia-Schlupp A, Pellissier JF, Fontes M. 2004. Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease. Nat Med 10:396-401.
22. Robertson AM, Huxley C, King RH, Thomas PK. 1999. Development of early postnatal peripheral nerve abnormalities in Trembler-J and PMP22 transgenic mice. J Anat 195:331-339.
23. Sahenk Z, Nagaraja HN, McCracken BS, King WM, Freimer ML, Cedarbaum JM, Mendell JR. 2005. NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients. Neurology 65:681-689.
24. Sebert ME, Shooter EM. 1993. Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury. J Neurosci Res 36:357-367.
25. Valentijn LJ, Baas F, Wolterman RA, Hoogendijk JE, van den Bosch NH, Zorn I, Gabreels-Festen AW, de Visser M, Bolhuis PA. 1992. Identical point mutations of PMP-22 in Trembler-J mouse and Charcot-Marie-Tooth disease type 1A. Nat Genet 2:288-291.
26. Yamauchi J, Chan JR, Shooter EM. 2003. Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Proc Natl Acad Sci U S A 100:14421-14426.