Absent p53 protein in colorectal tumor cells reflects poor survival

Journal of Applied Research

Volumn 2, Issue 3, 2002, Pages

  Mehta, Kumudini U ^a   Goldfarb, Michael A ^b   Zinterhofer, Louis J ^a  

^a Department of Pathology ^*

^b MONMOUTH MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Colorectal carcinoma; p53 protein

Indexed keywords

EID: 34948882716     PISSN: 1537064X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Finlay CA, Hinds PW, Levin AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083-1093, 1989.
2. Chen PW, Chen Y, Bookstein R, Lee WH. Genetic mechanisms of tumor suppression by the human p53 gene. Science 250:1576-1580, 1990.
3. Harris CC, Hollestein M. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 329:118-1327, 1993.
4. Symonds H, Krall L, Remington L, et al. P53-dependent apoptosis suppress tumor growth and progression in vivo. Cell 78:703-711, 1994.
5. Moll UM, Schramm LM. An acrobat in tumorigenesis. Crit Rev Oral Biol Med 9:23-37, 1998.
6. Harris CC. P53: At the Crossroad of Molecular Carcinogenesis and Risk Assessment. Science 262-1980-1981, 1993.
7. Blagosklonny MV. Loss of function and p53 protein stabilization. Oncogene 15:1889-1893, 1997.
8. Bray SE, Schorl C, Hall PA. The challenge of p53: linking biochemistry, biology and patient management. Stem Cells 16-248-260, 1998.
9. Blattner C, Tobiasch E, Litfen M, et al. DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation. Oncogene 18: 1723-1732, 1999;
10. Baker SJ, Markowitz S, Fearson ER, et al. Suppression of human colorectal carcinoma cell growth by wild type p53. Science 249:912-915, 1990.
11. Hollstein M, Sidransky D, Vogelstein B, Harris C. P53 Mutations in human cancer. Science 253:49-53, 1991.
12. Nigro JM, Baker SJ, Preisinger AC, et al. Mutations in the p53 gene occur in diverse human tumor types. Nature 342:705-708, 1989.
13. Hamelin R, Laurent-Pvig P, Oleschwang, et al. Association of p53 mutation with short survival in colorectal cancer. Gastroenterology 106:42-48, 1994.
14. Oren M, Rotter V. p53: The first 20 years. CMLS, Cell Mol Life Sci 55:9-11, 1999.
15. Yamaguchi A, Kvrosaka Y, Fushida S, et al. Expression of p53 protein in colorectal cancer and its relationship to short term prognosis. Cancer 70:2778-2784, 1992.
16. Tomodo H, Kekiji Y. Immunohistochemical analysis of p53 in colorectal cancer regarding clinicopathological correlation and prognostic significance. J Surg Oncol 58:125-128, 1995.
17. Levin AJ, Momad J, Finlay CA. The p53 tumor suppressor gene. Nature 351:453-456, 1991.
18. Ikeguchi M, Saito H, Katano K, et al. Clinicopathologic significance of the expression of mutated p53 protein and the proliferative activity of cancer cells in patients with esophageal squamous cell carcinoma. J Am Coll Surg 185:398-403, 1997.
19. Thor AD, Moore DH II, Edgeton SM, et al. Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancer. J Natl Cancer Inst 84:845-855, 1992.
20. Scott NP, Sagar P, Stewart J, et al. P53 in colorectal cancer: Clinicopathologic correlation and prognosis significance. Br J Cancer 63:317-319, 1991.
21. Joypaul BV, Hopwood D, Newman EL, et al. The prognostic significance of the accumulation of p53 tumor suppressor gene protein in gastric adenocarcinoma. Br J Cancer 69:943-946, 1994.
22. Remvikos Y, Tominage O, Hammel P, et al. Increased p53 protein content of colorectal tumors correlates with poor survival. Br J Cancer 66:758-764, 1992.
23. Sun XF, Carstensen JM, Zhang H, et al. Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 340:1369-1373, 1992.
24. Nathonson DS, Linden MD, Tender P, et al. Relationship among p53, stage & prognosis of large bowel cancer. Dis Colon Rectum 37:527-534, 1994.
25. Ahnen DJ, Feigs P, Quan G, et al. Ki Ras mutation and p53 overexpression predict the clinical behavior of colorectal cancers: A Southwest Oncology Group study. Cancer Res 58:1149-1158, 1998.
26. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580, 1981.
27. Jeng KS, Sheen IS, Chen BF, Wu JY. Is p53 gene mutation of prognostic value in hepatocellular carcinoma after resection?" Arch Surg 135:1329-1333, 2000.
28. Bell SM, Scott N, Cross D, et al. Prognostic value of p53 overexpression and C-Ki-Ras gene mutations in colorectal cancer. Gastroenterology 104:57-64, 1994.
29. Kern SE, Fearson ER, Kasper WF, et al. Allelic loss in colorectal carcinoma. JAMA 261:3099-3103, 1989.
30. Lleohart ME, Garcia-Foncilla SJ, Sanchez-Prieto R, et al. Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma. Cancer 83:889-895, 1998.
31. Forster S, et al. Microsatellite instability in sporadic carcinomas of the proximal colon: Association with diploid DNA content, negative protein expression of p53, and distinct histomorphological features. Surgery 123:13-18, 1998.
32. Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215-221, 1992.
33. Lane DP. Cancer: P53, guardian of the genome. Nature 358:15-16, 1992.