Synthesis, stereochemistry, and antimicrobial evaluation of t(3)-isopropyl-r(2), c(6)-di-2′-furanylpiperidin- 4-one and its derivatives

Medicinal Chemistry Research

Volumn 15, Issue 7-8, 2007, Pages 452-462

  Jayabharathi, J ^a   Manimekalai, A ^a   Selvaraj, R ^a   Praveena, A ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; PIPERIDINE DERIVATIVE; T(3) ISOPROPYL DI 2' FURANYLPIPERIDIN 4 ONE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CANDIDA ALBICANS; DRUG MECHANISM; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STEREOCHEMISTRY;

EID: 34948870244     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-006-0032-y     Document Type: Article

References (21)

1. Andotra CS, Kumar R (1990) Synthesis of substituted benzimidazole as anti-amebic agents. J Ind Chem Soc. 67: 76
2. Armarego WKF (1979) Quinazolines. Adv Heterocycl Chem 24: 1
3. Asobo P, Wahe A, Mbafov JT, Nkengfack AE, Fomum ZT, Soploue EF, Döpp D (2001) Heterocycles of biological importance. Part 5. The formation of novel biologically active pyrimido[1,2-a]benimidazoles from allenic nitrites and aminobenzimidazoles. J Chem Soc, Perkin Trans 1: 457
4. Douglas JR, Baker NF (1968) Experimental development of a cambandazole-resistant strain of haemonchus contortus in sheep. Ann Rev Pharm. 8: 213
5. Evans D, Kicks TA, Williamson WRN, Dawson NV, Meacocok SCR, Kitchen EA (1996) Synthesis of new substituted 6-(morpholin-4-yl)-1H-benzimidazole derivatives. J Med Chem. 31: 635
6. Ganellin CR, Spickett RGW (1965) Compounds affecting the central nervous system. I. 4-piperidones and related compounds. J Med Chem. 8(5): 619
7. Georgiev V, Petkova B (1974) Pharmacological studies of some central effects of tempidon. Acta Physiol Pharmacol Bulg. 2: 76
8. Ileana B, Dobre V, Duaz NJ (1985) Purification of 1-(2-Chloroethyl)-3- cyclohexyl 1-nitrosourea. J Prakt Chem. 327(4): 667
9. Iskarev NA, Shadurshkii KS (1965) Pharmacology of some 5-alkyl- and aryl-substituted 1,2,5-trimethylpiperidine-4-one. Farmacol Tokiskol. 28(2): 184
10. Jayabharathi J, Sivakumar R, Praveena A (2005) Synthesis and antimicrobial evaluation of some t(3)-alkyl and t(3),t(5)-dimethyl-r(2),c(6)-DI- 2′-furfurylpiperidin-4-one and its derivatives. Med Chem Res. 14(4): 198
11. 1,3-strain on the conformational preferences and stereodynamics of N-formyl-cis-2,6-diarylpiperidines. Indian J Chem. 38B: 325
12. Khaleque A, Bangladesh J (1978) Alkaloids of Nuphar japonicum, DC (water lily). Sci Indian Res. 13: 176
13. Krishnakumar R, Krishnapillay M (1993) Indian J Heterocycl Chem. 2: 379
14. Krishnapillay M, Krishnakumar R, Nagarajan A, Jeyaraman G (2000) Conformational analysis of some heterocyclic systems for two conformational analysis of substituted N-benzoylpiperidin-4-ones. Indian J Chem. 39B: 419
15. Mobia IG, Soldatendkov AT, Fedorov VO, Ageev EA, Sergeeva ND, Lin S, Stashenko EE, Prostakov NS, Andreeva EI (1989) Synthesis of some new heterocyclic derivatives. Part-2: N-acylpiperidones and their spectral studies. Kihm Farm Zh. 23(4): 421
16. Nalini CN (1997) M Pharm Dissertation, the Tamil Nadu Dr MGR Medical University, India
17. Ojha V, Singh J, Bhakuni DS, Singh S, Chatterjee RK (1991) Antiparasitic agents: para XIV-synthesis of 5-substituted 2-carbarkoxyamino-1H- benzimidazole as possible macrofilaricidal agents. Indian J Chem. 30B: 324
18. Ruiz P, Rodriguez-Cano F, Zerolo FJ, Casal M (2002) Investigation of the in vitro activity of streptomycin against Mycobacterium tuberculosis. Microb Drug Resist 8(2): 147
19. Solel Z (1970) Systemic fungicidal effect of benzimidazole derivatives and thiophanate against Cercospora leaf spot of sugar beet. Phytopathology. 66: 1186
20. Vankov S (1974) Effect of Tempidone on the cardiovascular system of experimental animals. J Nachnoizsled Khim Farm Inst. 9: 231
21. Walter S, Kinnard B, William J, Joseph BP (1965) Synthesis of some new heterocyclic derivatives. Part-2: N-acylpiperidones and their spectral studies. J Pharm Sci. 54(7): 1025