Synthesis of a group of 1H-benzimidazoles and their screening for antiinflammatory activity

European Journal of Medicinal Chemistry

Volumn 31, Issue 7-8, 1996, Pages 635-642

  Evans, D ^a   Hicks, T A ^a   Williamson, W R N ^a,b   Dawson, W ^a   Meacock, S C R ^a   Kitchen, E A ^a  

^a ELI LILLY AND COMPANY   (United States)

^b NONE   (United Kingdom)

Author keywords

Anti inflammatory activity; Substituted 1H benzimidazole

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADJUVANT DISEASE; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SHORT SURVEY;

EID: 0029812326     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)89560-2     Document Type: Article

References (20)

1. 1 Sokalova SA (1973) Patol Fiziol Eksp Ter 63, 63-64
2. 2 Fuveau SA (1972) Fr Demande 2092648
3. 3 Van Arman GG, Campbell WC (1975) Tex Rep Biol Med 33(2), 303-311
4. 4 Boido V, Spartore F (1974) Farmaco Ed Sci 29, 517-525
5. 5 Rahtz D, Wendt H, Koch H (1976) Ger Offen 2436883
6. 6 Clark RB, Feireira SH, Mehta NB, Thorogodd PB, Vinegar R (1977) Ger Offen 2634409
7. 7 Cashin CH, Dawson W, Kitchen EA (1977) J Pharm Pharmacol 29, 330-336
8. 8 Kanebo KK (1976) Jpn Pat 145495; (1979) Jpn Kokai Tokkyo Koho 79, 95, 734; (1980) Chem Abs 92, 82430b
9. 8 Kanebo KK (1976) Jpn Pat 145495; (1979) Jpn Kokai Tokkyo Koho 79, 95, 734; (1980) Chem Abs 92, 82430b
10. 8 Kanebo KK (1976) Jpn Pat 145495; (1979) Jpn Kokai Tokkyo Koho 79, 95, 734; (1980) Chem Abs 92, 82430b
11. 9 Andrews ER, Fleming RW, Grisar JM, Kihm JC, Wenstrup DL, Mayer GD (1974) J Med Chem 17, 882-886. Compound 52 is an analogue of the antiviral tilorone
12. 10 CF Green H, Day AR (1942) J Amer Chem Soc 64, 1167-1173
13. 11 Jurasek A, Kada R (1968) Chem Zvesti 22(4), 257-262; (1968) Chem Abs 69, 86061e
14. 11 Jurasek A, Kada R (1968) Chem Zvesti 22(4), 257-262; (1968) Chem Abs 69, 86061e
15. 12 Jurasek A, Kada R, Sticzay T (1969) Collect Czeck Chem Commun 34(2), 572-581; (1969) Chem Abs 70, 77864n
16. 12 Jurasek A, Kada R, Sticzay T (1969) Collect Czeck Chem Commun 34(2), 572-581; (1969) Chem Abs 70, 77864n
17. 13 Wheatley WB, Stiner GF (1957) J Org Chem 22, 923-925
18. 14 Kottenhahn AP, Seo ET, Stone HV (1963) J Org Chem 28, 3114-3120
19. 15 Cf Novelli A (1939) J Am Chem Soc 61, 520-521
20. 16 Easley WK, Sullivan MX (1952) J Am Chem Soc 74, 4450-4451