Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension

World Journal of Gastroenterology

Volumn 13, Issue 38, 2007, Pages 5065-5070

  Eizayaga, Francisco X ^a   Aguejouf, Omar ^b   Desplat, Vanessa ^b   Belon, Philippe ^c   Doutremepuich, Christian ^b  

^a DEPARTAMENTO DE CIENCIAS NATURALES Y ANTROPOLOGÍA   (Argentina)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c Laboratoires Boiron   (France)

Author keywords

COX 1; COX 2; COX selective inhibition; Portal hypertension; Ultra low dose aspirin

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 6 OXOPROSTAGLANDIN F1 ALPHA; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; LEUKOTRIENE B4; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PLACEBO; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE A2; THROMBOXANE B2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; CONTROLLED STUDY; DRUG POTENTIATION; IN VIVO STUDY; LOW DRUG DOSE; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PORTAL HYPERTENSION; RAT; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBUS; VEIN LIGATION;

EID: 34948868450     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i38.5065     Document Type: Article

References (24)

1. Vorobioff J, Bredfeldt JE, Groszmann RJ. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol 1983; 244: G52-G57
2. Albornoz L, Bandi JC, Otaso JC, Laudanno O, Mastai R. Prolonged bleeding time in experimental cirrhosis: role of nitric oxide. J Hepatol 1999; 30: 456-460
3. Hamilton G, Rosza I, Hutton F, Chow FP, Dandona P, Hobbs KE. Portal vein prostacyclin activity in experimental portal hypertension in rats. Clin Sci (Lond) 1981; 60: 327-329
4. Doutremepuich C, de Seze O, Le Roy D, Lalanne MC, Anne MC. Aspirin at very ultra low dosage in healthy volunteers: effects on bleeding time, platelet aggregation and coagulation. Haemostasis 1990; 20: 99-105
5. Lalanne MC, Doutremepuich C, de Seze O, Belon P. What is the effect of acetylsalicylic acid at ultra low dose on the interaction platelets/vessel wall? Thromb Res 1990; 60: 231-236
6. Eizayaga FX, Aguejouf O, Desplat V, Belon P, Doutremepuich C. Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension. Pathophysiol Haemost Thromb 2006; 35: 357-363
7. Taubert D, Berkels R, Grosser N, Schroder H, Grundemann D, Schomig E. Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action. Br J Pharmacol 2004; 143: 159-165
8. Lalanne MC, Ramboer I, de Seze O, Doutremepuich C. In vitro platelets/endothelial cells interactions in presence of acetylsalicylic acid at various dosages. Thromb Res 1992; 65: 33-43
9. Eizayaga FX, Aguejouf O, Belon P, Doutremepuich C. Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirin. Pathophysiol Haemost Thromb 2005; 34: 29-34
10. Ackerman Z, Karmeli F, Rachmilewitz D. Longitudinal prostaglandin E(2) generation in various organs during evolution of experimental portal hypertension. Prostaglandins Leukot Essent Fatty Acids 2002; 67: 197-201
11. Fabre JE, Nguyen M, Athirakul K, Coggins K, McNeish JD, Austin S, Parise LK, FitzGerald GA, Coffman TM, Koller BH. Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. J Clin Invest 2001; 107; 603-610
12. Doutremepuich C, Aguejouf O, Pintigny D, Sertillanges MN, De Seze O. Thrombogenic properties of ultra-low-dose of acetylsalicylic acid in a vessel model of laser-induced thrombus formation. Thromb Res 1994; 76: 225-229
13. Teng XW, Davies NM. High-performance liquid chromatographic analysis of a selective cyclooxygenase-1 inhibitor SC-560 in rat serum: application to pharmacokinetic studies. J Pharm Biomed Anal 2004; 35: 1143-1147
14. Wu Y, Burns C, Campbell KA, Sitzmann JV. Systemic and portal prostacyclin and thromboxane response to hemorrhage in portal hypertension. Shock 1994; 2: 68-71
15. Wu ZY, Chen XS, Qiu JF, Cao H. Role of PGI2 in the formation and maintenance of hyperdynamic circulatory state of portal hypertensive rats. World J Gastroenterol 2005; 11: 752-755
16. Potenza MA, Botrugno OA, De Salvia MA, Lerro G, Nacci C, Marasciulo FL, Andriantsitohaina R, Mitolo-Chieppa D. Endothelial COX-1 and -2 differentially affect reactivity of MVB in portal hypertensive rats. Am J Physiol Gastrointest Liver Physiol 2002; 283: G587-G594
17. Huang HC, Wang SS, Chen YC, Lee FY, Chang FY, Lin HC, Hou MC, Chan CC, Chen CT, Wu SL, Lee SD. Cyclooxygenase expression in splanchnic hyposensitivity to glypressin of bleeding portal hypertensive rats. Eur J Clin Invest 2003; 33: 505-512
18. Hou MC, Cahill PA, Zhang S, Wang YN, Hendrickson RJ, Redmond EM, Sitzmann JV. Enhanced cyclooxygenase-1 expression within the superior mesenteric artery of portal hypertensive rats: role in the hyperdynamic circulation. Hepatology 1998; 27: 20-27
19. Bouaziz A, de Ficquelmont-Loizos MM, Richert A, Caprani A. Direct physical factors and PGI2 and TXA2 secretions by a human endothelial cell line: in vitro investigation of pressure and shear stress applied independently or in synergy. Thromb Res 1998; 90: 279-289
20. Yokoyama Y, Toth B, Kitchens WC, Schwacha MG, Bland KI, Chaudry IH. Role of thromboxane in producing portal hypertension following trauma-hemorrhage. Am J Physiol Gastrointest Liver Physiol 2003; 285: G1293-G1299
21. Bezugla Y, Kolada A, Kamionka S, Bernard B, Scheibe R, Dieter P. COX-1 and COX-2 contribute differentially to the LPS-induced release of PGE2 and TxA2 in liver macrophages. Prostaglandins Other Lipid Mediat 2006; 79: 93-100
22. Wun T, Paglieroni T, Lachant NA. Physiologic concentrations of arginine vasopressin activate human platelets in vitro. Br J Haematol 1996; 92: 968-972
23. Huang HC, Wang SS, Chen YC, Lee FY, Chang FY, Lin HC, Hou MC, Chang CC, Lee SD. Chronic cyclooxygenase blockade enhances the vasopressin responsiveness in collaterals of portal hypertensive rats. Scand J Gastroenterol 2006; 41: 1440-1445
24. Buerkle MA, Lehrer S, Sohn HY, Conzen P, Pohl U, Krotz F. Selective inhibition of cyclooxygenase-2 enhances platelet adhesion in hamster arterioles in vivo. Circulation 2004; 110: 2053-2059