Inflammatory response of esophageal epithelium in combined-type esophagitis in rats: A transcriptome analysis

International Journal of Molecular Medicine

Volumn 18, Issue 5, 2006, Pages 821-828

  Naito, Yuji ^a   Kuroda, Masaaki ^a   Uchiyama, Kazuhiko ^a   Mizushima, Katsura ^a   Akagiri, Satomi ^a   Takagi, Tomohisa ^a   Handa, Osamu ^a   Kokura, Satoshi ^a   Yoshida, Norimasa ^a   Ichikawa, Hiroshi ^b   Yoshikawa, Toshikazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Esophagus; GeneChip; Inflammation; Reflux esophagitis; Transcriptome

Indexed keywords

ANIMAL; ARTICLE; DNA MICROARRAY; EPITHELIUM; ESOPHAGITIS; ESOPHAGUS; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; MUCOSA; PATHOLOGY; RAT; WISTAR RAT;

ANIMALS; EPITHELIUM; ESOPHAGITIS; ESOPHAGUS; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MUCOUS MEMBRANE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; TRANSCRIPTION, GENETIC;

EID: 34948866454     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.18.5.821     Document Type: Article

References (18)

1. Fitzgerald RC, Onwuegbusi BA, Bajaj-Elliott M, Saeed IT, Burnham WR and Farthing MJ: Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants. Gut 50: 451-459, 2002.
2. Isomoto H, Wang A, Mizuta Y, et al: Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis. Am J Gastroenterol 98: 551-556, 2003.
3. Yoshida N, Uchiyama K, Kuroda M, et al: Interleukin-8 expression in the esophageal mucosa of patients with gastro-esophageal reflux disease. Scand J Gastroenterol 39: 816-822, 2004.
4. Imamoto E, Yoshida N, Uchiyama K, et al: Effects of bile acids and acidic exposure on IL-8 expression in human esophageal epithelial cells. Gastroenterology 124: A-409, 2003.
5. Naito Y, Uchiyama K, Kuroda M, et al: Role of pancreatic trypsin in chronic esophagitis induced by gastroduodenal reflux in rats. J Gastroenterol 41: 198-208, 2006.
6. Naito Y, Uchiyama K, Kuroda M, et al: Laser capture micro-dissection/ GeneChip analysis of gene expression in glomerular cells in diabetic db/db mice. Redox Rep 9: 307-312, 2004.
7. Naito Y, Mizushima K and Yoshikawa T: Global analysis of gene expression in gastric ischemia-reperfusion: a future therapeutic direction for mucosal protective drugs. Dig Dis Sci 50 (suppl 1): S45-S55, 2005.
8. Cheng L, Cao W, Fiocchi C, et al: HCl-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis increased release of interleukin-6 by oesophageal mucosa in children with reflux oesophagitis. Am J Physiol Gastrointest Liver Physiol 11: 839-843, 2006.
9. Yoshida N, Katada K, Kuroda M, et al: Trypsin activates human esophageal epithelial cells to produce inflammatory cytokines through protease-activated receptor 2. Gastroenterology 126: A-501, 2004.
10. Oh TY, Lee JS, Ahn BO, et al: Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment. Free Radic Biol Med 30: 905-915, 2001.
11. Zhang F, Altorki NK, Wu YC, Soslow RA, Subbaramaiah K and Dannenberg AJ: Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids. Gastroenterology 121: 1391-1399, 2001.
12. Liebermann DA and Hoffman B: Myeloid differentiation (MyD) primary response genes in hematopoiesis. Blood Cells Mol Dis 31: 213-228, 2003.
13. Jin S, Antinore MJ, Lung FD, et al: The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J Biol Chem 275: 16602-16608, 2000.
14. Sheikh MS, Hollander MC and Fornance AJ Jr: Role of Gadd45 in apoptosis. Biochem Pharmacol 59: 43-45, 2000.
15. Takekawa M and Saito H: A family of stress-inducible GADD45- like proteins mediate activation of the stress-responsive MTK1/ MEKK4 MAPKKK. Cell 95: 521-530, 1998.
16. Mita H, Tsutsui J, Takekawa M, Witten EA and Saito H: Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol Cell Biol 22: 4544-4555, 2002.
17. Isomoto H, Nishi Y, Wang A, et al: Mucosal concentrations of proinflammatory cytokines and chemokines at gastric cardia: implication of Helicobacter pylori infection and gastroesophageal reflux. Am J Gastroenterol 99: 1063-1068, 2004.
18. O'Riordan JM, Abdel-latif MM, Ravi N, et al: Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia- adenocarcinoma sequence in the esophagus. Am J Gastroenterol 100: 1257-1264, 2005.