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Volumn 24, Issue 10, 2007, Pages 28-34

Crossing the blood-brain barrier: Integrating scientific innovation with socio-ethical reflection in predictive medicine

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[No Author keywords available]

Indexed keywords


EID: 34948861196     PISSN: 08932905     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (38)
  • 1
    • 12344334846 scopus 로고    scopus 로고
    • Clinical aspects of the MDR1 (ABCB1) gene polymorphism
    • Eichelbaum M, Fromm MF, Schwab M. Clinical aspects of the MDR1 (ABCB1) gene polymorphism. Ther Drug Monit. 2004;26:180-185.
    • (2004) Ther Drug Monit , vol.26 , pp. 180-185
    • Eichelbaum, M.1    Fromm, M.F.2    Schwab, M.3
  • 2
    • 19944425121 scopus 로고    scopus 로고
    • The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
    • Doran A, Obach RS, Smith BJ, et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos. 2005;33:165-174.
    • (2005) Drug Metab Dispos , vol.33 , pp. 165-174
    • Doran, A.1    Obach, R.S.2    Smith, B.J.3
  • 3
    • 4344561089 scopus 로고    scopus 로고
    • Functional expression and localization of P-glycoprotein in the central nervous system: Relevance to the pathogenesis and treatment of neurological disorders
    • Lee G, Bendayan R. Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders. Pharm Res. 2004;21:1313-1330.
    • (2004) Pharm Res , vol.21 , pp. 1313-1330
    • Lee, G.1    Bendayan, R.2
  • 4
    • 34247184192 scopus 로고    scopus 로고
    • Grapefruit juice, a glass full of drug interactions?
    • Kirby BJ, Unadkat JD. Grapefruit juice, a glass full of drug interactions? Clin Pharmacol Ther. 2007;81:631-633.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 631-633
    • Kirby, B.J.1    Unadkat, J.D.2
  • 5
    • 33847662941 scopus 로고    scopus 로고
    • Intestinal drug transporter expression and the impact of grapefruit juice in humans
    • Glaeser H, Bailey DG, Dresser GK, et al. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther. 2007;81:362-370.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 362-370
    • Glaeser, H.1    Bailey, D.G.2    Dresser, G.K.3
  • 6
    • 33750039999 scopus 로고    scopus 로고
    • Pharmacogenomics, informatics, and individual drug therapy in psychiatry: Past, present and future
    • Preskom SH. Pharmacogenomics, informatics, and individual drug therapy in psychiatry: past, present and future. J Psychopharmacol. 2006;20:85-94.
    • (2006) J Psychopharmacol , vol.20 , pp. 85-94
    • Preskom, S.H.1
  • 7
    • 34548718253 scopus 로고    scopus 로고
    • Evidence based management of nutrigenomics expectations and ELSIs
    • In press
    • Ozdemir V, Godard B. Evidence based management of nutrigenomics expectations and ELSIs. Pharmacogenomics. In press.
    • Pharmacogenomics
    • Ozdemir, V.1    Godard, B.2
  • 8
    • 4243167930 scopus 로고    scopus 로고
    • Strategies for consulting with the community: The cases of four large-scale genetic databases
    • Godard B, Marshall J, Laberge C, Knoppers BM. Strategies for consulting with the community: the cases of four large-scale genetic databases. Sci Eng Ethics. 2004;10:457-477.
    • (2004) Sci Eng Ethics , vol.10 , pp. 457-477
    • Godard, B.1    Marshall, J.2    Laberge, C.3    Knoppers, B.M.4
  • 10
    • 33845902748 scopus 로고    scopus 로고
    • Pharmacogenomic promises: Reflections on semantics, genohype and global justice
    • Einsiedel E, ed, Calgary, AB, Canada: University of Calgary Press. In press
    • Williams-Jones B, Ozdemir V. Pharmacogenomic promises: reflections on semantics, genohype and global justice. In: Einsiedel E, ed. Emerging Technologies: From Hindsight to Foresight. Calgary, AB, Canada: University of Calgary Press. In press.
    • Emerging Technologies: From Hindsight to Foresight
    • Williams-Jones, B.1    Ozdemir, V.2
  • 11
    • 34948889677 scopus 로고    scopus 로고
    • Genomics
    • Kuper A, Kuper J, eds, 3rd ed. London, UK: Routledge;
    • Rose N. Genomics. In: Kuper A, Kuper J, eds. The Social Science Encyclopedia. 3rd ed. London, UK: Routledge; 2004.
    • (2004) The Social Science Encyclopedia
    • Rose, N.1
  • 12
    • 33847019344 scopus 로고    scopus 로고
    • Mild cognitive impairment: Ethical considerations for nosological flexibility in human kinds
    • Graham J, Ritchie K. Mild cognitive impairment: ethical considerations for nosological flexibility in human kinds. Philos Psychol Psychiatry. 2006;13:31-43.
    • (2006) Philos Psychol Psychiatry , vol.13 , pp. 31-43
    • Graham, J.1    Ritchie, K.2
  • 13
    • 0033833430 scopus 로고    scopus 로고
    • Increased drug delivery to the brain by P-glycoprotein inhibition
    • Sadeque AJ, Wandel C, He H, et al. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther. 2000;68:231-237.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 231-237
    • Sadeque, A.J.1    Wandel, C.2    He, H.3
  • 14
    • 0037205138 scopus 로고    scopus 로고
    • In vitro P-glycoprotein affinity for atypical and conventional antipsychotics
    • Boulton DW, DeVane CL, Liston HL, Markowitz JS. In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002;71:163-169.
    • (2002) Life Sci , vol.71 , pp. 163-169
    • Boulton, D.W.1    DeVane, C.L.2    Liston, H.L.3    Markowitz, J.S.4
  • 15
    • 10644268555 scopus 로고    scopus 로고
    • The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein
    • Wang JS, Ruan Y, Taylor RM, et al. The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein. Int J Neuropsychopharmacol. 2004;7:415-419.
    • (2004) Int J Neuropsychopharmacol , vol.7 , pp. 415-419
    • Wang, J.S.1    Ruan, Y.2    Taylor, R.M.3
  • 16
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs
    • Urquhart BL, Tirona RG, Kim RB. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J Clin Pharmacol. 2007;47:566-578.
    • (2007) J Clin Pharmacol , vol.47 , pp. 566-578
    • Urquhart, B.L.1    Tirona, R.G.2    Kim, R.B.3
  • 17
    • 33644891064 scopus 로고    scopus 로고
    • MDR- and CYP3A4-mediated drug-herbal interactions
    • Pal D, Mitra AK. MDR- and CYP3A4-mediated drug-herbal interactions. Life Sci. 2006;78:2131-2145.
    • (2006) Life Sci , vol.78 , pp. 2131-2145
    • Pal, D.1    Mitra, A.K.2
  • 18
    • 0022337949 scopus 로고
    • Extremely rapid hydroxylation of debrisoquine: A case report with implication for treatment with nortriptyline and other tricyclic antidepressants
    • Bertilsson L, Aberg-Wistedt A, Gustafsson LL, Nordin C. Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants. Ther Drug Monit. 1985;7:478-480.
    • (1985) Ther Drug Monit , vol.7 , pp. 478-480
    • Bertilsson, L.1    Aberg-Wistedt, A.2    Gustafsson, L.L.3    Nordin, C.4
  • 19
    • 23844516328 scopus 로고    scopus 로고
    • Pharmacogenetics-based therapeutic recommendations - ready for clinical practice?
    • Kirchheiner J, Fuhr U, Brockmoller J, Pharmacogenetics-based therapeutic recommendations - ready for clinical practice? Nat Rev Drug Discov. 2005;4:639-647.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 639-647
    • Kirchheiner, J.1    Fuhr, U.2    Brockmoller, J.3
  • 20
    • 33749441773 scopus 로고    scopus 로고
    • Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4
    • Achira M, Suzuki H, Ito K, Sugiyama Y. Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4. AAPS PharmSci. 1999;1:E18.
    • (1999) AAPS PharmSci , vol.1
    • Achira, M.1    Suzuki, H.2    Ito, K.3    Sugiyama, Y.4
  • 21
    • 0032907322 scopus 로고    scopus 로고
    • Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
    • Kim RB, Wandel C, Leake B, et al. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999;16:408-414.
    • (1999) Pharm Res , vol.16 , pp. 408-414
    • Kim, R.B.1    Wandel, C.2    Leake, B.3
  • 22
    • 0345411341 scopus 로고    scopus 로고
    • P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies
    • Wandel C, Kim RB, Kajiji S, et al. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999;59:3944-3948.
    • (1999) Cancer Res , vol.59 , pp. 3944-3948
    • Wandel, C.1    Kim, R.B.2    Kajiji, S.3
  • 23
    • 33750035803 scopus 로고    scopus 로고
    • Positron emission tomography in acromegaly and other pituitary adenoma patients
    • Muhr C. Positron emission tomography in acromegaly and other pituitary adenoma patients. Neuroendocrinology. 2006;83:205-210.
    • (2006) Neuroendocrinology , vol.83 , pp. 205-210
    • Muhr, C.1
  • 24
    • 6044224985 scopus 로고    scopus 로고
    • Cerebral D2 and 5-HT2 receptor occupancy in schizophrenic patients treated with olanzapine or clozapine
    • Moresco RM, Cavallaro R, Messa C, et al. Cerebral D2 and 5-HT2 receptor occupancy in schizophrenic patients treated with olanzapine or clozapine. J Psychopharmacol. 2004;18:355-365.
    • (2004) J Psychopharmacol , vol.18 , pp. 355-365
    • Moresco, R.M.1    Cavallaro, R.2    Messa, C.3
  • 26
    • 33847080408 scopus 로고    scopus 로고
    • Mapping translational research in personalized therapeutics: From molecular markers to health policy
    • Ozdemir V, Williams-Jones B, Cooper DM, et al. Mapping translational research in personalized therapeutics: from molecular markers to health policy. Pharmacogenomics. 2007;8:177-185.
    • (2007) Pharmacogenomics , vol.8 , pp. 177-185
    • Ozdemir, V.1    Williams-Jones, B.2    Cooper, D.M.3
  • 30
    • 18844408610 scopus 로고    scopus 로고
    • Knowledge commons or economic engine - what's a university for?
    • Williams-Jones B. Knowledge commons or economic engine - what's a university for? J Med Ethics. 2005;31:249-250.
    • (2005) J Med Ethics , vol.31 , pp. 249-250
    • Williams-Jones, B.1
  • 31
    • 28944440034 scopus 로고    scopus 로고
    • Smart regulation: Will the government's strategy work?
    • Graham J. Smart regulation: will the government's strategy work? CMAJ. 2005;173:1469-1470.
    • (2005) CMAJ , vol.173 , pp. 1469-1470
    • Graham, J.1
  • 33
    • 0000938099 scopus 로고    scopus 로고
    • The future of the university and the university of the future: Evolution of ivory tower to entrepreneurial paradigm
    • Etzkowitz H, Webster A, Gebhardt C, Cantisano-Terra BR. The future of the university and the university of the future: evolution of ivory tower to entrepreneurial paradigm. Res Policy. 2000;29:313-330.
    • (2000) Res Policy , vol.29 , pp. 313-330
    • Etzkowitz, H.1    Webster, A.2    Gebhardt, C.3    Cantisano-Terra, B.R.4
  • 35
    • 0036264294 scopus 로고    scopus 로고
    • Ethical issues in bipolar disorders pedigree research: Privacy concerns, informed consent, and grounds for waiver
    • Parker LS. Ethical issues in bipolar disorders pedigree research: privacy concerns, informed consent, and grounds for waiver. Bipolar Disord. 2002;4:1-16.
    • (2002) Bipolar Disord , vol.4 , pp. 1-16
    • Parker, L.S.1
  • 36
    • 33947576426 scopus 로고    scopus 로고
    • Education, ethics and knowledge deficits in clinical pharmacogenetics
    • Hedgecoe A. Education, ethics and knowledge deficits in clinical pharmacogenetics. Pharmacogenomics. 2007;8:267-270.
    • (2007) Pharmacogenomics , vol.8 , pp. 267-270
    • Hedgecoe, A.1
  • 37
    • 29544449443 scopus 로고    scopus 로고
    • Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19
    • de Leon J, Armstrong SC, Cozza KL. Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. Psychosomatics. 2006;47:75-85.
    • (2006) Psychosomatics , vol.47 , pp. 75-85
    • de Leon, J.1    Armstrong, S.C.2    Cozza, K.L.3
  • 38
    • 23844516328 scopus 로고    scopus 로고
    • Pharmacogenetics-based therapeutic recommendations - ready for clinical practice?
    • Kirchheiner J, Fuhr U, Brockmoller J. Pharmacogenetics-based therapeutic recommendations - ready for clinical practice? Nat Rev Drug Discov. 2005;4:639-647.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 639-647
    • Kirchheiner, J.1    Fuhr, U.2    Brockmoller, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.