Dinucleoside analog synthesis via microwave activated cross coupling metathesis

Letters in Organic Chemistry

Volumn 2, Issue 7, 2005, Pages 613-615

  Colombeau, L ^a   Zerrouki, Rachida ^a   Krausz, P ^a   Champavier, Y ^b  

^a UNIVERSITÉ DE LIMOGES   (France)

^b UNIVERSITY OF LIMOGES   (France)

Author keywords

Cross metathesis; Dinucleosides; Grubbs catalyst; Microwave irradiation; Thymidine

Indexed keywords

EID: 34948851666     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017805774296885     Document Type: Review

References (28)

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26. α).
27. Typical procedure: 0.545 mmol of 1 (216 mg) dissolved in 3.0 mL of dry dichloromethane and 0.229 mmol (84 mg) of 2 in 3 mL of dry dichloromethane, were introduced in a round flask, under argon atmosphere; then 45 mg (0.055 mmol, 24% mol) of Grubbs I catalyst dissolved in 4 mL of dry dichloromethane were added slowly. Under stirring, the purple reaction mixture was irradiated by micro wave (38°C; 80 W) for 5 hours. The solvent of the resulting dark solution was removed under reduced pressure. The residue was purified by preparative TLC (chloroform/ethanol, 98/02, v/v) to give 3 in 71% yield (119 mg).
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