The relationship between nocturnal urinary leptin and gonadotrophins as children progress towards puberty

Hormone Research

Volumn 68, Issue 5, 2007, Pages 225-230

  Maqsood, Arfa R ^a   Trueman, Julie A ^a   Whatmore, Andrew J ^a   Westwood, Melissa ^a   Price, David A ^b   Hall, Catherine M ^b   Clayton, Peter E ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

Gonadotrophin; Leptin

Indexed keywords

FOLLITROPIN; GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE;

ADOLESCENT; AGE DISTRIBUTION; ARTICLE; CHILD DEVELOPMENT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLUOROMETRY; GONADOTROPIN RELEASE; HORMONE RELEASE; HORMONE URINE LEVEL; HUMAN; IMMUNOFLUORESCENCE; IMMUNORADIOMETRIC ASSAY; MALE; MEDICAL ASSESSMENT; NIGHT; PREPUBERTY; PRIORITY JOURNAL; PUBERTY; SCHOOL CHILD; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; URINALYSIS;

ADOLESCENT; CHILD; CIRCADIAN RHYTHM; FEMALE; GONADOTROPINS; HUMANS; LEPTIN; MALE; PUBERTY; SEX CHARACTERISTICS;

EID: 34948850885     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000101335     Document Type: Article

References (24)

1. Chehab FF, Mounzih K, Lu R, Lim ME: Early onset of reproductive function in normal female mice treated with leptin. Science 1997;275:88-90.
2. Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS: Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 1997;99:391-395.
3. Cheung CC, Thornton JE, Kuijper JL, Weigle DS, Clifton DK, Steiner RA: Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 1997;138:855-858.
4. Aubert ML, Pierroz DD, Gruaz NM, d'Alleves V, Vuagnat BA, Pralong FP, Blum WF, Sizonenko PC: Metabolic control of sexual function and growth: role of neuropeptide Y and leptin. Mol Cell Endocrinol 1998;140:107-113.
5. Clayton PE, Trueman JA: Leptin and puberty. Arch Dis Child 2000;83:1-4
6. Suter KJ, Pohl CR, Wilson ME: Circulating concentrations of nocturnal leptin, growth hormone and insulin-like growth factor-1 increase before the onset of puberty in agonadal male monkeys; potential signals for the initiation of puberty. J Clin Endocrinol Metab 2000;85:808-814.
7. Wilson ME, Jeffrey F, Chikazawa K, Yoda R, Legendre A, Mook D, Gould KG: Leptin administration increases nocturnal concentration of luteinizing hormone and growth hormone in juvenile female rhesus monkeys. J Clin Endocrinol Metab 2003;88:4874-4883.
8. Strobel A, Issad I, Camoin L, Ozata M, Strosberg AD: A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18:213-215.
9. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
10. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O'Rahilly S: Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-884.
11. Mantzoros CS, Flier JS, Rogol AD: A longitudinal assessment of hormonal and physical alteration during normal puberty in boys. 5. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82:1066-1070.
12. Quinton ND, Smith RF, Clayton PE, Gill MS, Shalet S, Justice SK, Simon SA, Walters S, Postel-Vinay MC, Blakemore AI, Ross RJ: Leptin binding activity changes with age: the link between leptin and puberty. J Clin Endocrinol Metab 1999;84:2336-2341.
13. Blum WF, Englaro P, Hanitsch S, Juul A, Hertal NT, Muller J, Skakkebaek NE, Heiman ML, Birket M, Attanasio AM, Kiess W, Rascher W: Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 1997;82:2904-2910.
14. Clayton PE, Gill MS, Hall CM, Tillman V, Whatmore AJ, Price DA: Serum leptin through childhood and adolescence. Clin Endocrinol 1997;46:727-733.
15. Ahmed ML, Ong KKL, Morell DJ, Cox L, Drayer N, Perry L, Preece MA, Dunger DB: Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab 1999;84:899-905.
16. Garcia-Mayor RV, Andrade A, Rios M, Lage M, Dieguez C, Casanueva FF: Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 1997;82:2849-2855.
17. Zaman N, Hall CM, Gill MS, Jones J, Tillmann V, Westwood M, Whatmore AJ, Clayton PE: Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine. Clin Endocrinol 2003;58:78-85.
18. Demir A, Dunkel L, Stenman UH, Voutilainen R: Age-related course of urinary gonadotropins in children. J Clin Endocrinol Metab 1995;80:1457-1460.
19. Demir A, Voutilainen R, Juul A, Dunkel L, Alfthan H, Skakkebaek N, Stenman UH: Increase in first morning voided urinary luteinizing hormone levels precedes the physical onset of puberty. J Clin Endocrinol Metab 1996;81:2963-2967.
20. Oerter KE, Uriarte MM, Rose SR, Barnes KM, Cutler GB: Gonadotrophin secretory dynamics during puberty in normal girls and boys. J Clin Endocrinol Metab 1990;71:1251-1258.
21. Mitamura R, Yano K, Suzuki N, Ito Y, Makita Y, Okuno A: Diurnal rhythms of luteinizing hormone, follicle stimulating hormone and testosterone secretion before the onset of male puberty. J Clin Endocrinol Metab 1999;84:29-37.
22. Mitamura R, Yano K, Suzuki N, Ito Y, Makita Y, Okuno A: Diurnal rhythms of luteinizing hormone, follicle stimulating hormone, testosterone and estradiol secretion before the onset of female puberty. J Clin Endocrinol Metab 2000;85:1074-1080.
23. Apter D, Butzow TL, Laughlin GA, Yen SS: Gonadotrophin-releasing hormone pulse generator activity during pubertal transition in girls: pulsatile and diurnal patterns of circulating gonadotrophins. J Clin Endocrinol Metab 1993;76:940-949.
24. Gill MS, Hall CM, Tillmann V, Clayton PE: Constitutional delay in growth and puberty is associated with hypoleptinemia. Clin Endocrinol 1999;50:721-726.