메뉴 건너뛰기




Volumn 6, Issue 3, 2007, Pages 200-212

Targeting the Brain: Rationalizing the novel methods of drug delivery to the central nervous system

Author keywords

Cerebral; Pharmacokinetics; Regional; Selective

Indexed keywords

ANTIINFECTIVE AGENT; BRADYKININ DERIVATIVE; CARVEDILOL; CLOTRIMAZOLE; CYCLOSPORIN A; CYTOKINE; DACTINOMYCIN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIRUBICIN; GLYCOPROTEIN P; IMMUNOTOXIN; LEUKOTRIENE; LEVODOPA; LOBRADIMIL; MONOCLONAL ANTIBODY; NIMODIPINE; PHENOBARBITAL; RESERPINE; RIFAMPICIN; VERAPAMIL; VINBLASTINE;

EID: 34948841572     PISSN: 15416933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12028-007-0034-8     Document Type: Review
Times cited : (9)

References (87)
  • 1
    • 0028923459 scopus 로고
    • Why do all drugs work in animals but none in stroke patients? 1. Drugs promoting cerebral blood flow [Review]
    • Del Zoppo GJ. Why do all drugs work in animals but none in stroke patients? 1. Drugs promoting cerebral blood flow [Review]. J Intern Med 1995;237(1):79-88.
    • (1995) J Intern Med , vol.237 , Issue.1 , pp. 79-88
    • Del Zoppo, G.J.1
  • 2
    • 0030869483 scopus 로고    scopus 로고
    • Drug delivery to the brain (Review Article)
    • Pardridge WM. Drug delivery to the brain (Review Article). J Cereb Blood Flow Metab 1997;17(7):713-31.
    • (1997) J Cereb Blood Flow Metab , vol.17 , Issue.7 , pp. 713-731
    • Pardridge, W.M.1
  • 3
    • 36949012104 scopus 로고    scopus 로고
    • The evolution of big brains
    • Evolving brains in scientific American Library, First Edition, p
    • Allman JM. The evolution of big brains. Evolving brains in scientific American Library Series 1999 (First Edition), p. 158-208.
    • (1999) Series , pp. 158-208
    • Allman, J.M.1
  • 4
    • 0020355917 scopus 로고
    • Hemorrhagic encephalitis produced by selective non-occlusive intracarotid BCNU injection in dogs
    • Omojola MF, Fox AJ, Auer RN, Vinuela FV. Hemorrhagic encephalitis produced by selective non-occlusive intracarotid BCNU injection in dogs J Neurosurg 1982;57(6):791-6.
    • (1982) J Neurosurg , vol.57 , Issue.6 , pp. 791-796
    • Omojola, M.F.1    Fox, A.J.2    Auer, R.N.3    Vinuela, F.V.4
  • 5
    • 0023778449 scopus 로고
    • Arterial drug infusion: Pharmacokinetic problems and pitfalls
    • Dedrick RL. Arterial drug infusion: pharmacokinetic problems and pitfalls. J Natl Cancer Inst 1988;80(2):84-9.
    • (1988) J Natl Cancer Inst , vol.80 , Issue.2 , pp. 84-89
    • Dedrick, R.L.1
  • 6
    • 0038311753 scopus 로고    scopus 로고
    • The acute cerebrovascular effects of intracarotid adenosine in nonhuman primates
    • Joshi S, Hartl R, Wang M, et al. The acute cerebrovascular effects of intracarotid adenosine in nonhuman primates. Anesth Analg 2003;97(1):231-7.
    • (2003) Anesth Analg , vol.97 , Issue.1 , pp. 231-237
    • Joshi, S.1    Hartl, R.2    Wang, M.3
  • 7
    • 0031770323 scopus 로고    scopus 로고
    • The feasibility of intracarotid adenosine for the manipulation of human cerebrovascular resistance
    • Joshi S, Young WL, Pile-Spellman J, et al. The feasibility of intracarotid adenosine for the manipulation of human cerebrovascular resistance. Anesth Analg 1998;87:1291-8.
    • (1998) Anesth Analg , vol.87 , pp. 1291-1298
    • Joshi, S.1    Young, W.L.2    Pile-Spellman, J.3
  • 8
    • 0027604576 scopus 로고
    • The blood-brain barrier: Morphology, molecules, and neurothelin
    • Schlosshauer B. The blood-brain barrier: morphology, molecules, and neurothelin. Bioessays 1993;15(5):341-6.
    • (1993) Bioessays , vol.15 , Issue.5 , pp. 341-346
    • Schlosshauer, B.1
  • 9
    • 0030971953 scopus 로고    scopus 로고
    • Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions
    • Vaz R, Sarmento A, Borges N, Cruz C, Azevedo I. Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions. Acta Neurochir 1997;139(3):215-20.
    • (1997) Acta Neurochir , vol.139 , Issue.3 , pp. 215-220
    • Vaz, R.1    Sarmento, A.2    Borges, N.3    Cruz, C.4    Azevedo, I.5
  • 10
  • 11
    • 0033304395 scopus 로고    scopus 로고
    • Drug transfer across the blood-brain barrier and improvement of brain delivery
    • Jolliet-Riant P, Tillement JP. Drug transfer across the blood-brain barrier and improvement of brain delivery. Fundam Clin Pharmacol 1999;13(1):16-26.
    • (1999) Fundam Clin Pharmacol , vol.13 , Issue.1 , pp. 16-26
    • Jolliet-Riant, P.1    Tillement, J.P.2
  • 12
    • 0026638367 scopus 로고
    • Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cells
    • Raub TJ, Kuentzel SL, Sawada GA. Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells. Exp Cell Res 1992;199(2):330-40.
    • (1992) Exp Cell Res , vol.199 , Issue.2 , pp. 330-340
    • Raub, T.J.1    Kuentzel, S.L.2    Sawada, G.A.3
  • 13
    • 0029655250 scopus 로고    scopus 로고
    • Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients
    • Claudio L. Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients. Acta Neuropathol 1996;91(1):6-14.
    • (1996) Acta Neuropathol , vol.91 , Issue.1 , pp. 6-14
    • Claudio, L.1
  • 14
    • 0036588454 scopus 로고    scopus 로고
    • Isolation and molecular characterization of brain microvascular endothelial cells from human brain tumors
    • Unger RE, Oltrogge JB, von Briesen H, et al. Isolation and molecular characterization of brain microvascular endothelial cells from human brain tumors. In Vitro Cell Dev Biol Anim 2002;38(5):273-81.
    • (2002) In Vitro Cell Dev Biol Anim , vol.38 , Issue.5 , pp. 273-281
    • Unger, R.E.1    Oltrogge, J.B.2    von Briesen, H.3
  • 15
    • 0001698201 scopus 로고
    • Cerebral circulation (Chapter 5)
    • Shepherd JT, Abboud FM, editors, Bethesda, MD: American Physiological Society;
    • Heistad DD, Kontos HA. Cerebral circulation (Chapter 5). In: Shepherd JT, Abboud FM, editors. Handbook of physiology: section 2: the cardiovascular system. Bethesda, MD: American Physiological Society; 1983. p. 137-82.
    • (1983) Handbook of physiology: Section 2: the cardiovascular system , pp. 137-182
    • Heistad, D.D.1    Kontos, H.A.2
  • 16
    • 0028012869 scopus 로고
    • Blood-brain barrier transport and brain metabolism of adenosine and adenosine analogs
    • Pardridge WM, Yoshikawa T, Kang Y-S, Miller LP. Blood-brain barrier transport and brain metabolism of adenosine and adenosine analogs. J Pharmacol Exp Therap 1994;268(1):14-8.
    • (1994) J Pharmacol Exp Therap , vol.268 , Issue.1 , pp. 14-18
    • Pardridge, W.M.1    Yoshikawa, T.2    Kang, Y.-S.3    Miller, L.P.4
  • 17
    • 0020592356 scopus 로고
    • Neurotoxicity of chemotherapeutic agents after blood-brain barrier modification: Neuropathological studies
    • Neuwelt EA, Glasberg M, Frenkel E, Barnett P. Neurotoxicity of chemotherapeutic agents after blood-brain barrier modification: neuropathological studies. Ann Neurol 1983;14(3):316-24.
    • (1983) Ann Neurol , vol.14 , Issue.3 , pp. 316-324
    • Neuwelt, E.A.1    Glasberg, M.2    Frenkel, E.3    Barnett, P.4
  • 18
    • 0033974507 scopus 로고    scopus 로고
    • Osmotic opening of the blood-brain barrier: Principles, mechanism, and therapeutic applications
    • Rapoport SI. Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cell Mol Neurobiol 2000;20(2):217-30.
    • (2000) Cell Mol Neurobiol , vol.20 , Issue.2 , pp. 217-230
    • Rapoport, S.I.1
  • 19
    • 0031305483 scopus 로고    scopus 로고
    • The mechanism of reversible osmotic opening of the blood-brain barrier: Role of intracellular calcium ion in capillary endothelial cells
    • Nagashima T, Ikeda K, Wu S, Kondo T, Yamaguchi M, Tamaki N. The mechanism of reversible osmotic opening of the blood-brain barrier: role of intracellular calcium ion in capillary endothelial cells. Acta Neurochir - Supplementum 1997;70:231-3.
    • (1997) Acta Neurochir - Supplementum , vol.70 , pp. 231-233
    • Nagashima, T.1    Ikeda, K.2    Wu, S.3    Kondo, T.4    Yamaguchi, M.5    Tamaki, N.6
  • 20
    • 0034028065 scopus 로고    scopus 로고
    • In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans
    • Siegal T, Rubinstein R, Bokstein F, et al. In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans. J Neurosurg 2000;92(4):599-605.
    • (2000) J Neurosurg , vol.92 , Issue.4 , pp. 599-605
    • Siegal, T.1    Rubinstein, R.2    Bokstein, F.3
  • 21
    • 10544254259 scopus 로고    scopus 로고
    • Quantification and pharmacokinetics of blood-brain barrier disruption in humans
    • Zunkeler B, Carson RE, Olson J, et al. Quantification and pharmacokinetics of blood-brain barrier disruption in humans. J Neurosurg 1996;85(6):1056-65.
    • (1996) J Neurosurg , vol.85 , Issue.6 , pp. 1056-1065
    • Zunkeler, B.1    Carson, R.E.2    Olson, J.3
  • 22
    • 0023751696 scopus 로고
    • The effect on the tumor vessel permeability by hyperosmotic blood brain barrier disruption]
    • Miyagami M, Tazoe M, Kagawa Y, Tsubokawa T. [The effect on the tumor vessel permeability by hyperosmotic blood brain barrier disruption]. No To Shinkei 1988;40(9):875-82.
    • (1988) No To Shinkei , vol.40 , Issue.9 , pp. 875-882
    • Miyagami, M.1    Tazoe, M.2    Kagawa, Y.3    Tsubokawa, T.4
  • 23
    • 0036290379 scopus 로고    scopus 로고
    • Synergistic effect of cold mannitol and Na(+)/Ca(2+) exchange blocker on blood-brain barrier opening
    • Ikeda M, Bhattacharjee AK, Kondoh T, Nagashima T, Tamaki N. Synergistic effect of cold mannitol and Na(+)/Ca(2+) exchange blocker on blood-brain barrier opening. Biochem Biophys Res Commun 2002;291(3):669-74.
    • (2002) Biochem Biophys Res Commun , vol.291 , Issue.3 , pp. 669-674
    • Ikeda, M.1    Bhattacharjee, A.K.2    Kondoh, T.3    Nagashima, T.4    Tamaki, N.5
  • 24
    • 7044247812 scopus 로고    scopus 로고
    • The effects of magnesium sulfate on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats
    • Kaya M, Gulturk S, Elmas I, et al. The effects of magnesium sulfate on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. Life Sci 2004;76(2):201-12.
    • (2004) Life Sci , vol.76 , Issue.2 , pp. 201-212
    • Kaya, M.1    Gulturk, S.2    Elmas, I.3
  • 25
    • 15944385652 scopus 로고    scopus 로고
    • Effects of intracarotid injection of methyl-prednisolone on cellular oedema after osmotic opening of the blood-brain barrier in rats
    • Kozler P, Pokorny J. Effects of intracarotid injection of methyl-prednisolone on cellular oedema after osmotic opening of the blood-brain barrier in rats. Prague Med Rep 2004;105(3):279-90.
    • (2004) Prague Med Rep , vol.105 , Issue.3 , pp. 279-290
    • Kozler, P.1    Pokorny, J.2
  • 26
    • 0020327951 scopus 로고
    • Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: The factor of the blood-brain barrier
    • Neuwelt EA, Barnett PA, Bigner DD, Frenkel EP. Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. Proc Natl Acad Sci USA 1982;79(14):4420-3.
    • (1982) Proc Natl Acad Sci USA , vol.79 , Issue.14 , pp. 4420-4423
    • Neuwelt, E.A.1    Barnett, P.A.2    Bigner, D.D.3    Frenkel, E.P.4
  • 27
    • 0034791298 scopus 로고    scopus 로고
    • Effects of mild hypothermia on blood-brain barrier disruption during isoflurane or pentobarbital anesthesia
    • Chi OZ, Liu X, Weiss HR. Effects of mild hypothermia on blood-brain barrier disruption during isoflurane or pentobarbital anesthesia. Anesthesiology 2001;95(4):933-8.
    • (2001) Anesthesiology , vol.95 , Issue.4 , pp. 933-938
    • Chi, O.Z.1    Liu, X.2    Weiss, H.R.3
  • 28
    • 0024206648 scopus 로고
    • Structural changes in the rat brain after carotid infusions of hyperosmolar solutions. An electron microscopic study
    • Salahuddin TS, Johansson BB, Kalimo H, Olsson Y. Structural changes in the rat brain after carotid infusions of hyperosmolar solutions. An electron microscopic study. Acta Neuropathol (Berl) 1988;77(1):5-13.
    • (1988) Acta Neuropathol (Berl) , vol.77 , Issue.1 , pp. 5-13
    • Salahuddin, T.S.1    Johansson, B.B.2    Kalimo, H.3    Olsson, Y.4
  • 29
    • 0023705227 scopus 로고
    • Observations on exsudation of fibronectin, fibrinogen and albumin in the brain after carotid infusion of hyperosmolar solutions. An immunohistochemical study in the rat indicating longlasting changes in the brain microenvironment and multifocal nerve cell injuries
    • Salahuddin TS, Kalimo H, Johansson BB, Olsson Y. Observations on exsudation of fibronectin, fibrinogen and albumin in the brain after carotid infusion of hyperosmolar solutions. An immunohistochemical study in the rat indicating longlasting changes in the brain microenvironment and multifocal nerve cell injuries. Acta Neuropathol (Berl) 1988;76(1):1-10.
    • (1988) Acta Neuropathol (Berl) , vol.76 , Issue.1 , pp. 1-10
    • Salahuddin, T.S.1    Kalimo, H.2    Johansson, B.B.3    Olsson, Y.4
  • 30
    • 1642504354 scopus 로고    scopus 로고
    • Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries
    • Erdlenbruch B, Alipour M, Fricker G, et al. Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries. Br J Pharmacol 2003;140(7):1201-10.
    • (2003) Br J Pharmacol , vol.140 , Issue.7 , pp. 1201-1210
    • Erdlenbruch, B.1    Alipour, M.2    Fricker, G.3
  • 31
    • 0024557336 scopus 로고
    • Polyamines mediate the reversible opening of the blood-brain barrier by the intracarotid infusion of hyperosmolal mannitol
    • Koenig H, Goldstone AD, Lu CY. Polyamines mediate the reversible opening of the blood-brain barrier by the intracarotid infusion of hyperosmolal mannitol. Brain Res 1989;483(1):110-6.
    • (1989) Brain Res , vol.483 , Issue.1 , pp. 110-116
    • Koenig, H.1    Goldstone, A.D.2    Lu, C.Y.3
  • 32
    • 0030888267 scopus 로고    scopus 로고
    • Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas
    • Black KL, Cloughesy T, Huang SC, et al. Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. J Neurosurg 1997;86(4):603-9.
    • (1997) J Neurosurg , vol.86 , Issue.4 , pp. 603-609
    • Black, K.L.1    Cloughesy, T.2    Huang, S.C.3
  • 33
    • 0024346949 scopus 로고
    • The somatosensory evoked potential as a noninvasive method to determine flow rates for hyperosmotic disruption of the blood-brain barrier
    • Warnke PC, Phillips A, Bernstein LP, Groothuis DR. The somatosensory evoked potential as a noninvasive method to determine flow rates for hyperosmotic disruption of the blood-brain barrier. Neurosurgery 1989;25(3):405-11.
    • (1989) Neurosurgery , vol.25 , Issue.3 , pp. 405-411
    • Warnke, P.C.1    Phillips, A.2    Bernstein, L.P.3    Groothuis, D.R.4
  • 34
    • 0031965788 scopus 로고    scopus 로고
    • Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means [Comments by Paul L. Kornblith, Michael Pollay, Pierre-Yves Dietrich and Nicolas de Tribolet, Berislav Zlokovic]
    • Kroll RA, Neuwelt EA. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means [Comments by Paul L. Kornblith, Michael Pollay, Pierre-Yves Dietrich and Nicolas de Tribolet, Berislav Zlokovic]. Neurosurgery 1998;42(5):1083-100.
    • (1998) Neurosurgery , vol.42 , Issue.5 , pp. 1083-1100
    • Kroll, R.A.1    Neuwelt, E.A.2
  • 35
    • 0026671923 scopus 로고
    • Selective blood-tumor barrier disruption by leukotrienes
    • Chio CC, Baba T, Black KL. Selective blood-tumor barrier disruption by leukotrienes. J Neurosurg 1992;77(3):407-10.
    • (1992) J Neurosurg , vol.77 , Issue.3 , pp. 407-410
    • Chio, C.C.1    Baba, T.2    Black, K.L.3
  • 36
    • 32344438099 scopus 로고    scopus 로고
    • Study of correlation between expression of bradykinin B2 receptor and pathological grade in human gliomas
    • Zhao Y, Xue Y, Liu Y, et al. Study of correlation between expression of bradykinin B2 receptor and pathological grade in human gliomas. Br J Neurosurg 2005;19(4):322-6.
    • (2005) Br J Neurosurg , vol.19 , Issue.4 , pp. 322-326
    • Zhao, Y.1    Xue, Y.2    Liu, Y.3
  • 37
    • 30544447180 scopus 로고    scopus 로고
    • Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound
    • Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochem Biophys Res Commun 2006;340(4):1085-90.
    • (2006) Biochem Biophys Res Commun , vol.340 , Issue.4 , pp. 1085-1090
    • Kinoshita, M.1    McDannold, N.2    Jolesz, F.A.3    Hynynen, K.4
  • 38
    • 0242385616 scopus 로고    scopus 로고
    • Altered blood-brain barrier permeability and its effect on the distribution of Evans blue and sodium fluorescein in the rat brain applied by intracarotid injection
    • Kozler P, Pokorny J. Altered blood-brain barrier permeability and its effect on the distribution of Evans blue and sodium fluorescein in the rat brain applied by intracarotid injection. Physiol Res 2003;52(5):607-14.
    • (2003) Physiol Res , vol.52 , Issue.5 , pp. 607-614
    • Kozler, P.1    Pokorny, J.2
  • 39
    • 0345404212 scopus 로고    scopus 로고
    • The effects of pentobarbital on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats
    • Chi OZ, Chun TW, Liu X, Weiss HR. The effects of pentobarbital on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. Anesth Anal 1998;86(6):1230-5.
    • (1998) Anesth Anal , vol.86 , Issue.6 , pp. 1230-1235
    • Chi, O.Z.1    Chun, T.W.2    Liu, X.3    Weiss, H.R.4
  • 40
    • 0035182616 scopus 로고    scopus 로고
    • Efficacy of intratumoral delivery of mitoxantrone in recurrent malignant glial tumours
    • Boiardi A, Eoli M, Salmaggi A, et al. Efficacy of intratumoral delivery of mitoxantrone in recurrent malignant glial tumours. J Neurooncol 2001;54(1):39-47.
    • (2001) J Neurooncol , vol.54 , Issue.1 , pp. 39-47
    • Boiardi, A.1    Eoli, M.2    Salmaggi, A.3
  • 41
    • 33645213642 scopus 로고    scopus 로고
    • Neeves KB, Lo CT, Foley CP, Saltzman WM, Olbricht WL. Fabrication and characterization of microfluidic probes for convection enhanced drug delivery. J Control Release 2006;111(3):252-62
    • Neeves KB, Lo CT, Foley CP, Saltzman WM, Olbricht WL. Fabrication and characterization of microfluidic probes for convection enhanced drug delivery. J Control Release 2006;111(3):252-62.
  • 44
    • 5644291816 scopus 로고    scopus 로고
    • Heparin and air filters reduce embolic events caused by intra-arterial cerebral angiography: A prospective, randomized trial
    • Bendszus M, Koltzenburg M, Bartsch AJ, et al. Heparin and air filters reduce embolic events caused by intra-arterial cerebral angiography: a prospective, randomized trial. Circulation 2004;110(15):2210-5.
    • (2004) Circulation , vol.110 , Issue.15 , pp. 2210-2215
    • Bendszus, M.1    Koltzenburg, M.2    Bartsch, A.J.3
  • 45
    • 33644973534 scopus 로고    scopus 로고
    • Silent cerebral ischaemia: Hidden fingerprints of invasive medical procedures
    • Bendszus M, Stoll G. Silent cerebral ischaemia: hidden fingerprints of invasive medical procedures. Lancet Neurol 2006;5(4):364-72.
    • (2006) Lancet Neurol , vol.5 , Issue.4 , pp. 364-372
    • Bendszus, M.1    Stoll, G.2
  • 46
    • 0027406243 scopus 로고
    • Microscopic air embolism during cerebral angiography and strategies for its avoidance [see comments]
    • Markus H, Loh A, Israel D, Buckenham T, Clifton A, Brown MM. Microscopic air embolism during cerebral angiography and strategies for its avoidance [see comments]. Lancet 1993;341(8848):784-7.
    • (1993) Lancet , vol.341 , Issue.8848 , pp. 784-787
    • Markus, H.1    Loh, A.2    Israel, D.3    Buckenham, T.4    Clifton, A.5    Brown, M.M.6
  • 47
    • 0023778449 scopus 로고
    • Arterial drug infusion: Pharmacokinetic problems and pitfalls
    • Dedrick RL. Arterial drug infusion: pharmacokinetic problems and pitfalls. J Natl Cancer Inst 1988;80(2):84-9.
    • (1988) J Natl Cancer Inst , vol.80 , Issue.2 , pp. 84-89
    • Dedrick, R.L.1
  • 49
    • 0026741926 scopus 로고
    • Do anticancer agents reach the tumor target in the human brain?
    • Donelli MG, Zucchetti M, D'Incalci M. Do anticancer agents reach the tumor target in the human brain? Cancer Chemoth Pharmacol 1992;30(4):251-60.
    • (1992) Cancer Chemoth Pharmacol , vol.30 , Issue.4 , pp. 251-260
    • Donelli, M.G.1    Zucchetti, M.2    D'Incalci, M.3
  • 50
    • 0013136924 scopus 로고    scopus 로고
    • Cerebral and spinal cord blood flow
    • Cottrell JE, Smith DS Eds, 4th ed. St. Louis: Mosby Inc
    • Joshi S, Ornstein E, Young WL. Cerebral and spinal cord blood flow. In: Cottrell JE, Smith DS (Eds) Anesthesia and Neurosurgery. 4th ed. St. Louis: Mosby Inc.; 2001 pp. 19-68.
    • (2001) Anesthesia and Neurosurgery , pp. 19-68
    • Joshi, S.1    Ornstein, E.2    Young, W.L.3
  • 52
    • 0025847949 scopus 로고
    • Intravascular streaming during carotid artery infusions. Demonstration in humans and reduction using diastole-phased pulsatile administration
    • Saris SC, Blasberg RG, Carson RE, et al. Intravascular streaming during carotid artery infusions. Demonstration in humans and reduction using diastole-phased pulsatile administration. J Neurosurg 1991;74(5):763-72.
    • (1991) J Neurosurg , vol.74 , Issue.5 , pp. 763-772
    • Saris, S.C.1    Blasberg, R.G.2    Carson, R.E.3
  • 53
    • 0023617730 scopus 로고
    • Carotid artery mixing with diastole-phased pulsed drug infusion
    • Saris SC, Shook DR, Blasberg RG, et al. Carotid artery mixing with diastole-phased pulsed drug infusion. J Neurosurg 1987;67(5):721-5.
    • (1987) J Neurosurg , vol.67 , Issue.5 , pp. 721-725
    • Saris, S.C.1    Shook, D.R.2    Blasberg, R.G.3
  • 54
    • 1642408511 scopus 로고    scopus 로고
    • Intracarotid verapamil decreases both proximal and distal human cerebrovascular resistance
    • Joshi S, Meyers P, Pile-Spellman J, Wang M, Sahlein D. Intracarotid verapamil decreases both proximal and distal human cerebrovascular resistance. Anesthesiology 2004;100(4):774-81.
    • (2004) Anesthesiology , vol.100 , Issue.4 , pp. 774-781
    • Joshi, S.1    Meyers, P.2    Pile-Spellman, J.3    Wang, M.4    Sahlein, D.5
  • 55
    • 0035117457 scopus 로고    scopus 로고
    • Intraarterial chemotherapy for brain tumors by using a spatial dose fractionation algorithm and pulsatile delivery
    • Gobin YP, Cloughesy TF, Chow KL, et al. Intraarterial chemotherapy for brain tumors by using a spatial dose fractionation algorithm and pulsatile delivery. Radiology 2001;218(3):724-32.
    • (2001) Radiology , vol.218 , Issue.3 , pp. 724-732
    • Gobin, Y.P.1    Cloughesy, T.F.2    Chow, K.L.3
  • 56
  • 57
    • 0020107861 scopus 로고
    • Drug entry into and distribution within brain and cerebrospinal fluid: [14C]urea pharmacokinetics
    • Rapoport SI, Fitzhugh R, Pettigrew KD, Sundaram U, Ohno K. Drug entry into and distribution within brain and cerebrospinal fluid: [14C]urea pharmacokinetics. Am J Physiol 1982;242(3):R339-48.
    • (1982) Am J Physiol , vol.242 , Issue.3
    • Rapoport, S.I.1    Fitzhugh, R.2    Pettigrew, K.D.3    Sundaram, U.4    Ohno, K.5
  • 58
    • 0031695039 scopus 로고    scopus 로고
    • Blood-brain barrier permeation: Molecular parameters governing passive diffusion
    • Fischer H, Gottschlich R, Seelig A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J Membr Biol 1998;165(3):201-11.
    • (1998) J Membr Biol , vol.165 , Issue.3 , pp. 201-211
    • Fischer, H.1    Gottschlich, R.2    Seelig, A.3
  • 59
    • 0016354690 scopus 로고
    • Lipid solubility and drug penetration of the blood brain barrier
    • Oldendorf WH. Lipid solubility and drug penetration of the blood brain barrier. Proc Soc Exp Biol Med 1974;147(3):813-5.
    • (1974) Proc Soc Exp Biol Med , vol.147 , Issue.3 , pp. 813-815
    • Oldendorf, W.H.1
  • 60
    • 0030961786 scopus 로고    scopus 로고
    • Blood-to-brain transfer of various oxicams: Effects of plasma binding on their brain delivery
    • Jolliet P, Simon N, Bree F, et al. Blood-to-brain transfer of various oxicams: effects of plasma binding on their brain delivery. Pharm Res 1997;14(5):650-6.
    • (1997) Pharm Res , vol.14 , Issue.5 , pp. 650-656
    • Jolliet, P.1    Simon, N.2    Bree, F.3
  • 61
    • 0028158735 scopus 로고
    • A method to determine the ability of drugs to diffuse through the blood-brain barrier
    • Seelig A, Gottschlich R, Devant RM. A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proc Natl Acad Sci USA 1994;91(1):68-72.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.1 , pp. 68-72
    • Seelig, A.1    Gottschlich, R.2    Devant, R.M.3
  • 62
    • 0025064041 scopus 로고
    • Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brain
    • Greig NH, Daly EM, Sweeney DJ, Rapoport SI. Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brain. Cancer Chemother Pharmacol 1990;25(5):320-5.
    • (1990) Cancer Chemother Pharmacol , vol.25 , Issue.5 , pp. 320-325
    • Greig, N.H.1    Daly, E.M.2    Sweeney, D.J.3    Rapoport, S.I.4
  • 63
    • 0025290649 scopus 로고
    • Brain targeting of anti-HIV nucleosides: Synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3′-azido-2′,3′-dideoxyuridine and 3′-azido-3′-deoxythymidine
    • Chu CK, Bhadti VS, Doshi KJ, et al. Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3′-azido-2′,3′-dideoxyuridine and 3′-azido-3′-deoxythymidine. J Med Chem 1990;33(8):2188-92.
    • (1990) J Med Chem , vol.33 , Issue.8 , pp. 2188-2192
    • Chu, C.K.1    Bhadti, V.S.2    Doshi, K.J.3
  • 64
    • 0001842719 scopus 로고    scopus 로고
    • Blood-brain barrier transport mechanisms
    • Welch KMA, Caplan LR, Reis DJ, Siesjo BK, Weir B Eds, Academic Press Inc;
    • Pardridge WM. Blood-brain barrier transport mechanisms. In: Welch KMA, Caplan LR, Reis DJ, Siesjo BK, Weir B (Eds) Primer on cerebrovascular diseases. Academic Press Inc; 1997: pp. 21-5.
    • (1997) Primer on cerebrovascular diseases , pp. 21-25
    • Pardridge, W.M.1
  • 65
    • 17844372759 scopus 로고    scopus 로고
    • New prospects for glycopeptide based analgesia: Glycoside-induced penetration of the blood-brain barrier
    • Dhanasekaran M, Polt R. New prospects for glycopeptide based analgesia: glycoside-induced penetration of the blood-brain barrier. Curr Drug Deliv 2005;2(1):59-73.
    • (2005) Curr Drug Deliv , vol.2 , Issue.1 , pp. 59-73
    • Dhanasekaran, M.1    Polt, R.2
  • 66
    • 0030447660 scopus 로고    scopus 로고
    • Brain drug delivery of small molecules using immunoliposomes
    • Huwyler J, Wu D, Pardridge WM. Brain drug delivery of small molecules using immunoliposomes. Proc Natl Acad Sci USA 1996;93(24):14164-9.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.24 , pp. 14164-14169
    • Huwyler, J.1    Wu, D.2    Pardridge, W.M.3
  • 67
    • 0029079310 scopus 로고
    • Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo
    • Pardridge WM, Boado RJ, Kang YS. Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo. Proc Natl Acad Sci USA 1995;92(12):5592-6.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.12 , pp. 5592-5596
    • Pardridge, W.M.1    Boado, R.J.2    Kang, Y.S.3
  • 68
    • 0025740904 scopus 로고
    • Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate
    • Triguero D, Buciak JL, Pardridge WM. Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate. J Pharmacol Exp Therap 1991;258(1):186-92.
    • (1991) J Pharmacol Exp Therap , vol.258 , Issue.1 , pp. 186-192
    • Triguero, D.1    Buciak, J.L.2    Pardridge, W.M.3
  • 69
    • 0023152529 scopus 로고
    • Cationization of protein antigens. I. Alteration of immunogenic properties
    • Muckerheide A, Apple RJ, Pesce AJ, Michael JG. Cationization of protein antigens. I. Alteration of immunogenic properties. J Immunol 1987;138(3):833-7.
    • (1987) J Immunol , vol.138 , Issue.3 , pp. 833-837
    • Muckerheide, A.1    Apple, R.J.2    Pesce, A.J.3    Michael, J.G.4
  • 70
    • 0033404109 scopus 로고    scopus 로고
    • Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes
    • Fresta M, Puglisi G. Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes. Pharm Res 1999;16(12):1843-9.
    • (1999) Pharm Res , vol.16 , Issue.12 , pp. 1843-1849
    • Fresta, M.1    Puglisi, G.2
  • 71
    • 0031771965 scopus 로고    scopus 로고
    • Transcranial Doppler pattern after intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere in patients with vasospasm
    • Kanamaru K, Waga S, Kuga Y, Nakamura F, Kamata N. Transcranial Doppler pattern after intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere in patients with vasospasm. Neurol Med-Chir 1998;38 Suppl:152-5.
    • (1998) Neurol Med-Chir , vol.38 , Issue.SUPPL. , pp. 152-155
    • Kanamaru, K.1    Waga, S.2    Kuga, Y.3    Nakamura, F.4    Kamata, N.5
  • 72
    • 0141453819 scopus 로고    scopus 로고
    • New systems for delivery of drugs to the brain in neurological disease
    • Cornford EM, Cornford ME. New systems for delivery of drugs to the brain in neurological disease. Lancet Neurol 2002;1(5):306-15.
    • (2002) Lancet Neurol , vol.1 , Issue.5 , pp. 306-315
    • Cornford, E.M.1    Cornford, M.E.2
  • 74
    • 12344321374 scopus 로고    scopus 로고
    • Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method
    • Moriki Y, Suzuki T, Fukami T, Hanano M, Tomono K, Watanabe J. Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method. Biol Pharm Bull 2004;27(6):932-5.
    • (2004) Biol Pharm Bull , vol.27 , Issue.6 , pp. 932-935
    • Moriki, Y.1    Suzuki, T.2    Fukami, T.3    Hanano, M.4    Tomono, K.5    Watanabe, J.6
  • 75
    • 10844229402 scopus 로고    scopus 로고
    • Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells
    • Yang ZY, Liu GQ. Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells. Pharmazie 2004;59(12):952-6.
    • (2004) Pharmazie , vol.59 , Issue.12 , pp. 952-956
    • Yang, Z.Y.1    Liu, G.Q.2
  • 76
    • 23944455088 scopus 로고    scopus 로고
    • Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells
    • Maines LW, Antonetti DA, Wolpert EB, Smith CD. Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology 2005;49(5):610-7.
    • (2005) Neuropharmacology , vol.49 , Issue.5 , pp. 610-617
    • Maines, L.W.1    Antonetti, D.A.2    Wolpert, E.B.3    Smith, C.D.4
  • 77
    • 20544434626 scopus 로고    scopus 로고
    • Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus
    • Iannetti P, Spalice A, Parisi P. Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus. Epilepsia 2005;46(6):967-9.
    • (2005) Epilepsia , vol.46 , Issue.6 , pp. 967-969
    • Iannetti, P.1    Spalice, A.2    Parisi, P.3
  • 78
    • 30544440661 scopus 로고    scopus 로고
    • New positron emission tomography tracer [(11)C]carvedilol reveals P-glycoprotein modulation kinetics
    • Bart J, Dijkers EC, Wegman TD, et al. New positron emission tomography tracer [(11)C]carvedilol reveals P-glycoprotein modulation kinetics. Br J Pharmacol 2005;145(8):1045-51.
    • (2005) Br J Pharmacol , vol.145 , Issue.8 , pp. 1045-1051
    • Bart, J.1    Dijkers, E.C.2    Wegman, T.D.3
  • 79
    • 31144434780 scopus 로고    scopus 로고
    • In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil
    • Lee YJ, Maeda J, Kusuhara H, et al. In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil. J Pharmacol Exp Ther 2006;316(2):647-53.
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.2 , pp. 647-653
    • Lee, Y.J.1    Maeda, J.2    Kusuhara, H.3
  • 80
    • 0028239193 scopus 로고
    • Human monoclonal antibody-drug conjugates in the experimental treatment of malignant gliomas-studies in vitro and in vivo
    • Zhu J, Takahashi H, Nakazawa S. Human monoclonal antibody-drug conjugates in the experimental treatment of malignant gliomas-studies in vitro and in vivo. Neurol Med-Chir 1994;34(5):279-85.
    • (1994) Neurol Med-Chir , vol.34 , Issue.5 , pp. 279-285
    • Zhu, J.1    Takahashi, H.2    Nakazawa, S.3
  • 81
    • 0036001387 scopus 로고    scopus 로고
    • Pharmaceutical strategies utilizing recombinant human serum albumin
    • Chuang VT, Kragh-Hansen U, Otagiri M. Pharmaceutical strategies utilizing recombinant human serum albumin. Pharm Res 2002;19(5):569-77.
    • (2002) Pharm Res , vol.19 , Issue.5 , pp. 569-577
    • Chuang, V.T.1    Kragh-Hansen, U.2    Otagiri, M.3
  • 82
    • 0037066034 scopus 로고    scopus 로고
    • Local delivery of plasmid DNA into rat carotid artery using ultrasound
    • Taniyama Y, Tachibana K, Hiraoka K, et al. Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 2002;105(10):1233-9.
    • (2002) Circulation , vol.105 , Issue.10 , pp. 1233-1239
    • Taniyama, Y.1    Tachibana, K.2    Hiraoka, K.3
  • 83
    • 1542377267 scopus 로고    scopus 로고
    • Gene transfer with ultrasound and microbubbles (optison) as a potential treatment for cardiovascular diseases]. Nippon Ronen Igakkai Zasshi
    • Taniyama Y, Tomita N, Endoh S, Kaneda Y, Ogihara T, Morishita R. [Gene transfer with ultrasound and microbubbles (optison) as a potential treatment for cardiovascular diseases]. Nippon Ronen Igakkai Zasshi - Jpn J Geriatr 2004;41(1):51-4.
    • (2004) Jpn J Geriatr , vol.41 , Issue.1 , pp. 51-54
    • Taniyama, Y.1    Tomita, N.2    Endoh, S.3    Kaneda, Y.4    Ogihara, T.5    Morishita, R.6
  • 84
    • 0027936457 scopus 로고
    • Reduced blood-brain barrier permeability after cardiac arrest by conjugated superoxide dismutase and catalase in piglets
    • discussion 4-5
    • Schleien CL, Eberle B, Shaffner DH, Koehler RC, Traystman RJ. Reduced blood-brain barrier permeability after cardiac arrest by conjugated superoxide dismutase and catalase in piglets. Stroke 1994;25(9):1830-4; discussion 4-5.
    • (1994) Stroke , vol.25 , Issue.9 , pp. 1830-1834
    • Schleien, C.L.1    Eberle, B.2    Shaffner, D.H.3    Koehler, R.C.4    Traystman, R.J.5
  • 85
    • 0025071023 scopus 로고
    • Bloodbrain barrier integrity during cardiopulmonary resuscitation in dogs
    • Schleien CL, Koehler RC, Shaffner DH, Traystman RJ. Bloodbrain barrier integrity during cardiopulmonary resuscitation in dogs. Stroke 1990;21(8):1185-91.
    • (1990) Stroke , vol.21 , Issue.8 , pp. 1185-1191
    • Schleien, C.L.1    Koehler, R.C.2    Shaffner, D.H.3    Traystman, R.J.4
  • 86
    • 0032561733 scopus 로고    scopus 로고
    • Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat
    • Uchino H, Elmer E, Uchino K, et al. Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat. Brain Res 1998;812(1-2):216-26.
    • (1998) Brain Res , vol.812 , Issue.1-2 , pp. 216-226
    • Uchino, H.1    Elmer, E.2    Uchino, K.3
  • 87
    • 33748768996 scopus 로고    scopus 로고
    • Detection of BBB disruption and hemorrhage by Gd-DTPA enhanced MRI after embolic stroke in rat
    • Ding G, Jiang Q, Li L, et al. Detection of BBB disruption and hemorrhage by Gd-DTPA enhanced MRI after embolic stroke in rat. Brain Res 2006;1114(1):195-203.
    • (2006) Brain Res , vol.1114 , Issue.1 , pp. 195-203
    • Ding, G.1    Jiang, Q.2    Li, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.