Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: A prospective, controlled animal experiment

Critical Care

Volumn 11, Issue , 2007, Pages

  Li, Li Fu ^a,b   Liao, Shuen Kuei ^a   Lee, Cheng Huei ^a,b   Huang, Chung Chi ^a,b   Quinn, Deborah A ^c,d  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MACROPHAGE INFLAMMATORY PROTEIN 2; PROTEIN KINASE B; CYTOKINE; PROTEIN SERINE THREONINE KINASE;

AMBIENT AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; C57BL 6 MOUSE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HYPEROXIA; LUNG SEQUESTRATION; MALE; MOUSE; MOUSE MUTANT; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN SYNTHESIS; TIDAL VOLUME; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DISEASE MODEL; ENZYMOLOGY; LUNG; METABOLISM; RANDOMIZATION; REFERENCE VALUE;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; HYPEROXIA; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NITRIC OXIDE SYNTHASE TYPE III; PROSPECTIVE STUDIES; PROTEIN-SERINE-THREONINE KINASES; RANDOM ALLOCATION; REFERENCE VALUES; RESPIRATION, ARTIFICIAL;

EID: 34948830672     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc6101     Document Type: Article

References (32)

1. Dreyfuss D Saumon G Ventilator-induced lung injury - lessons from experimental studies Am J Respir Crit Care Med 1998 157 294-323 9445314
2. Quinn DA Moufarrej RK Volokhov A Hales CA Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury J Appl Physiol 2002 93 517-525 12133859
3. Clark JM Lambertson CJ Pulmonary oxygen toxicity: A review Pharmacol Rev 1971 23 37-133 4948324
4. Kazzaz JA Xu J Palaia TA Mantell L Fein AM Horowitz S Cellular oxygen toxicity J Biol Chem 1996 271 15182-15186 10.1074/jbc.271.25.15182 8662947
5. Sinclair SE Altemeier WA Matute-Bello G Chi EY Augmented lung injury due to interaction between hyperoxia and mechanical ventilation Crit Care Med 2004 32 2496-2501 10.1097/01.CCM.0000148231.04642.8D 15599157
6. Bailey TC Martin EL Zhao L Veldhuizen RAW High oxygen concentrations predispose mouse lungs to the deleterious effects of high stretch ventilation J Appl Physiol 2003 94 975-982 12571129
7. Held HD Boettcher S Hamann L Uhlig S Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-κB and is blocked by steroids Am J Respir Crit Care Med 2001 163 711-716 11254529
8. Pugin J Dunn I Jolliet P Tassaux D Magnenat JL Nicod LP Chevrolet JC Activation of human macrophages by mechanical ventilation in vitro Am J Physiol Lung Cell Mol Physiol 1998 275 L1040-L1050
9. Allen GL Menendez IY Ryan MA Mazor RL Wispé JR Fiedler MA Wong HR Hyperoxia synergistically increases TNF-α-induced interleukin-8 gene expression in A549 cells Am J Physiol Lung Cell Mol Physiol 2000 278 L253-L260 10666108
10. Kunkel SL Standiford T Kasahara K Strieter RM Interleukin-8 (IL-8): The major neutrophil chemotactic factor in the lung Exp Lung Res 1991 17 17-23 2013270
11. Schmal H Shanley TP Jones ML Friedl HP Ward PA Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats J Immunol 1996 156 1963-1972 8596051
12. Li LF Liao SK Ko YS Lee CH Quinn DA Hyperoxia increases ventilation-induced lung injury via mitogen-activated protein kinases: A prospective, controlled animal experiment Crit Care 2007 11 R25 10.1186/ cc5704 17316425
13. Belperio JA Keane MP Burdick MD Londhe V Xue YY Li K Phillips RJ Strieter RM Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury J Clin Invest 2002 110 1703-1716 151632 12464676 10.1172/JCI200215849
14. Uhlig U Fehrenbach H Lachmann RA Goldmann T Lachmann B Vollmer E Uhlig S Phosphoinoside 3-OH kinase inhibition prevents ventilation-induced lung cell activation Am J Respir Crit Care Med 2004 169 201-208 10.1164/ rccm.200303-343OC 14578214
15. Yum HK Arcaroli J Kupfner J Shenkar R Penninger JM Sasaki T Yang KY Park JS Abraham E Involvement of phosphoinositide 3-kinase in neutrophil activation and the development of acute lung injury J Immnunol 2001 167 6601-6608
16. Quinn AC Petros AJ Vallance P Nitric oxide: An endogenous gas Br J Anaesth 1995 74 443-451 10.1093/bja/74.4.443 7734266
17. Moncada S Higgs A The L-arginine-nitric oxide pathway N Engl J Med 1993 329 2002-2012 10.1056/NEJM199312303292706 7504210
18. Mayhan WG Nitric oxide donor-induced increase in permeability of the blood-brain barrier Brain Res 2000 866 101-108 10.1016/ S0006-8993(00)02254-X 10825485
19. Dimmeler S Fleming I Fisslthaler B Hermann C Busse R Zeiher AM Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 1999 399 601-605 10.1038/21224 10376603
20. Choi WI Quinn DA Park KM Moufarrej RK Jafari B Syrkina O Bonventre JV Hales CA Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury Am J Respir Crit Care Med 2003 167 1627-1632 10.1164/rccm.200210-1216OC 12663326
21. Li LF Yu L Quinn DA Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase Am J Respir Crit Care Med 2004 169 518-524 10.1164/rccm.200305-660OC 14644930
22. Cho H Thorvaldsen JL Chu Q Feng F Birnbaum MJ Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice J Biol Chem 2001 276 38349-38352 10.1074/jbc.C100462200 11533044
23. Wilson MR Choudhury S Goddard ME O'Dea KP Nicholson AG Takata M High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury J Appl Physiol 2003 95 1385-1393 12807894
24. Bai KJ Spicer AP Mascarenhas MM Yu L Ochoa CD Garg HG Quinn DA The role of hyaluronan synthase 3 in ventilator-induced lung injury Am J Respir Crit Care Med 2005 172 92-98 10.1164/rccm.200405-652OC 15790861
25. Li LF Liao SK Lee CH Tsai YH Huang CC Quinn DA Ventilation-induced neutrophil infiltration and apoptosis depend on apoptosis signal-regulated kinase 1 pathway Crit Care Med 2005 33 1913-1921 10.1097/01.CCM.0000178179.48050.BC 16148459
26. Uhlig S Ventilation-induced lung injury and mechanotransduction: stretching it too far? Am J Physiol Lung Cell Mol Physiol 2002 282 L892-L896 11943651
27. 2+ release in cardiomyocytes Nat Cell Biol 2001 3 867-873 10.1038/ncb1001-867 11584267
28. Thelen M Didichenko SA G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils Ann NY Acad Sci 1997 832 368-382 10.1111/ j.1749-6632.1997.tb46265.x 9704065
29. Toker A Protein kinases as mediators of phosphoinositide 3-kianse signaling Mol Pharmacol 2000 57 652-658 10727509
30. Stein RC Waterfield MD PI3-kinase inhibition: A target for drug development? Mol Med Today 2000 6 347-357 10.1016/S1357-4310(00)01770-6 10954868
31. Khwaja A Akt is more than just a Bad kinase Nature 1999 401 33-34 10.1038/43354 10485701
32. Li LF Ouyang B Choukroun G Matyal R Mascarenhas M Jafari B Bonventre JV Force T Quinn DA Stretch-induced IL-8 depends on c-Jun-terminal and nuclear factor-κB-inducing kinases Am J Physiol Lung Cell Mol Physiol 2003 285 L464-L475 12716652