The utility of SMAD4 as a diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors

Diagnostic Cytopathology

Volumn 35, Issue 10, 2007, Pages 644-648

  Ali, Sarfraz ^a   Cohen, Cynthia ^a   Little, James V ^a   Sequeira, Judy H ^a   Mosunjac, Marina B ^a   Siddiqui, Momin T ^a  

^a EMORY UNIVERSITY HOSPITAL   (United States)

Author keywords

DPC4; Fine needle aspiration; Pancreatic adenocarcinoma; SMAD4

Indexed keywords

SMAD4 PROTEIN;

ARTICLE; ASPIRATION BIOPSY; BREAST CANCER; CANCER DIAGNOSIS; CANCER SURGERY; COLON CANCER; ENDOMETRIUM CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MAJOR CLINICAL STUDY; MELANOMA; OVARY CANCER; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLID TUMOR;

ADENOCARCINOMA; ALLELES; BIOPSY, FINE-NEEDLE; FEMALE; HUMANS; MUTATION; NEOPLASMS; PANCREATIC NEOPLASMS; RETROSPECTIVE STUDIES; SMAD4 PROTEIN; TUMOR MARKERS, BIOLOGICAL;

EID: 34948819749     PISSN: 87551039     EISSN: 10970339     Source Type: Journal    
DOI: 10.1002/dc.20715     Document Type: Article

References (27)

1. Solcia E, Capeila C, Kloppel G. Tumors of the pancreas. In: Rosai J, Sobin LH, editors. AFIP atlas of tumor pathology, 3rd series, fascicle 20. Washington, DC: Armed Forces Institute of Pathology; 1997. p 31-130.
2. Miller BA, Koloenel LN, Berstein L. Racial/ethnic patterns of cancer in the United States 1998-92. Bethseda, MD: National Cancer Institute; 1996. NIH publication No. 96-4104.
3. Wade TP, Halaby IA, Stapleton DR, et al. Population based analysis of treatment of pancreatic cancer and Whipple resection: Department of defense hospitals 1989-1994. Surgery 1996;120: 680-687.
4. American Cancer Society. Facts and figures 2007. Atlanta: American Cancer Society; 2007.
5. Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet 2004;363:1049-1057.
6. Kloppel G. Pathology and classification of tumor of the exocrine pancreas. In: Trede M, Carter DC, editors. Surgery of the pancreas. 2nd ed. Edinburgh: Churchill Livingstone; 1997. p 447-462.
7. Gold EB, Golding SB. Epidemiology of and risk factors for pancreatic cancer. Surg Oncol Clin N Am 1998;7:67.
8. Wilentz RE, Su GH, Dai JL, et al. Immunohistochemistry labeling for Dpc4 mirrors genetic status in pancreatic and peri-pancreatic adenocarcinomas: A new marker of DPC4 inactivation. Am J Pathol 2000;156:37-43.
9. Hahn SA, Schutte M, Hoque ATMS, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-353.
10. Hahn SA, Hoque ATMS, Moskaluk CA, et al. Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res 1996;56:490-494.
11. Schutte M, Hruban RH, Hedrick L, et al. DPC4 gene in various tumor types. Cancer Res 1996;56:2527-2530.
12. Liu F. SMAD4/DPC4 and pancreatic cancer survival. Clin Cancer Res 2001;7:3853-3856.
13. Schwarte-Waldhoff I, Schmiegel W. Smad4 transcriptional pathways and angiogenesis. Int J Gastrointest Cancer 2002;31:47-59.
14. Real FX. A 'catastrophic hypothesis' for pancreas cancer progression. Gastroenterology 2003;124:1958-1964.
15. Hruban R, Wilentz R, Kern S. Genetic progression in the pancreatic ducts. Am J Pathol 2000;156:1821-1825.
16. Duffy JP, Eibl G, Reber HA, Hines OJ. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol Cancer 2003;2:12.
17. Miyazono K, ten Dijke P, Heldin CH. TGF-β signaling by Smad proteins. Adv Immunol 2000;75:115-157.
18. Derynck R, Akhurst RJ, Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat Genet 2001;29:117-129.
19. Markowitz S, Wang J, Myeroff L, et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 1995;268:1336-1338.
20. Miyaki M, Iijima T, Konishi M, et al. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 1999;18:3098-3103.
21. Wang D, Kanuma T, Mizunuma H, et al. Analysis of specific gene mutations in the transforming growth factor-β signal transduction pathway in human ovarian cancer. Cancer Res 2000;60:4507-4512.
22. Ijichi H, Ikenoue T, Kato N, et al. Systemic analysis of the TGF-β-SMAD signaling pathway in gastrointestinal cancer cells. Biochem Biophys Res Commun 2001;289:350-357.
23. Takagi Y, Kohmura H, Futamura M, et al. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology 1996;111:1369-1372.
24. Wilentz RE, Iacobuzio-Donahue CA, Argani P, et al. Loss of expression of DPC4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 2000;60:2002-2006.
25. Schutte M, Hruban RH, Hedrick L, et al. DPC4 gene in various tumor types. Cancer Res 1996;56:2527-2530.
26. Biankin AV, Morey AL, Lee C, et al. DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma. J Clin Oncol 2002;20:4531-4542.
27. McCarthy DM, Brat DJ, Wilentz RE, et al. Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma: Analysis of progression and recurrence of DPC4 immunohistochemical labeling. Hum Pathol 2001;32:638-642.