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Volumn 29, Issue 5, 2007, Pages 619-625

Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease

Author keywords

Inflammatory bowel disease; Methotrexate; Methotrexate polyglutamates; Pharmacokinetics; Therapeutic drug monitoring

Indexed keywords

FOLIC ACID; MESALAZINE; METHOTREXATE; METHOTREXATE POLYGLUTAMATE; PREDNISOLONE;

EID: 34848925807     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31811f39bb     Document Type: Article
Times cited : (48)

References (43)
  • 1
    • 0024517127 scopus 로고
    • Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease
    • Kozarek RA, Patterson DJ, Gelfand MD, et al. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989;110:353-356.
    • (1989) Ann Intern Med , vol.110 , pp. 353-356
    • Kozarek, R.A.1    Patterson, D.J.2    Gelfand, M.D.3
  • 2
    • 1542603602 scopus 로고    scopus 로고
    • Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn's disease: A randomised, investigator-blind study
    • Ardizzone SB, Manzionna G, Imbesi V, et al. Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn's disease: a randomised, investigator-blind study. Dig Liver Dis. 2003;35:619-627.
    • (2003) Dig Liver Dis , vol.35 , pp. 619-627
    • Ardizzone, S.B.1    Manzionna, G.2    Imbesi, V.3
  • 3
    • 0009447497 scopus 로고    scopus 로고
    • Methotrexate in Crohn's disease: Results of a randomized, double-blind, placebo-controlled trial
    • Arora S, Katkov W, Cooley J, et al. Methotrexate in Crohn's disease: results of a randomized, double-blind, placebo-controlled trial. Hepatogastroenterology. 1999;46:1724-1729.
    • (1999) Hepatogastroenterology , vol.46 , pp. 1724-1729
    • Arora, S.1    Katkov, W.2    Cooley, J.3
  • 4
    • 0030784425 scopus 로고    scopus 로고
    • Methotrexate in chronic active Crohn's disease: A double-blind, randomized, Israeli multicenter trial
    • Oren R, Moshkowitz M, Odes S, et al. Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial. Am J Gastroenterol. 1997;92:2203-2209.
    • (1997) Am J Gastroenterol , vol.92 , pp. 2203-2209
    • Oren, R.1    Moshkowitz, M.2    Odes, S.3
  • 5
    • 0028899859 scopus 로고
    • Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators
    • Feagan BG, Rochon J, Fedorak RN, et al. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. N Engl J Med. 1995;332:292-297.
    • (1995) N Engl J Med , vol.332 , pp. 292-297
    • Feagan, B.G.1    Rochon, J.2    Fedorak, R.N.3
  • 6
    • 0034214336 scopus 로고    scopus 로고
    • A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators
    • Feagan BG, Fedorak RN, Irvine EJ, et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. N Engl J Med. 2000;342:1627-1632.
    • (2000) N Engl J Med , vol.342 , pp. 1627-1632
    • Feagan, B.G.1    Fedorak, R.N.2    Irvine, E.J.3
  • 7
    • 0033679444 scopus 로고    scopus 로고
    • 6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease
    • Mate-Jimenez J, Hermida C, Cantero-Perona J, et al. 6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2000;12:1227-1233.
    • (2000) Eur J Gastroenterol Hepatol , vol.12 , pp. 1227-1233
    • Mate-Jimenez, J.1    Hermida, C.2    Cantero-Perona, J.3
  • 9
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohns disease: A meta-analysis
    • Pearson DC, May GR, Fick GH, et al. Azathioprine and 6-mercaptopurine in Crohns disease: a meta-analysis. Ann Intern Med. 1995;123:132-142.
    • (1995) Ann Intern Med , vol.123 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3
  • 10
    • 4544239107 scopus 로고    scopus 로고
    • Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease
    • Gearry RB, Barclay ML, Burt MJ, et al. Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease. Pharmacoepidemiology and Drug Safety. 2004;13:563-567.
    • (2004) Pharmacoepidemiology and Drug Safety , vol.13 , pp. 563-567
    • Gearry, R.B.1    Barclay, M.L.2    Burt, M.J.3
  • 12
    • 0031958113 scopus 로고    scopus 로고
    • Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment
    • Chladek J, Martinkova J, Simkova M, et al. Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment. Eur J Clin Pharmacol. 1998;53:437-444.
    • (1998) Eur J Clin Pharmacol , vol.53 , pp. 437-444
    • Chladek, J.1    Martinkova, J.2    Simkova, M.3
  • 13
  • 14
    • 1342289022 scopus 로고    scopus 로고
    • Combining infliximab and methotrexate in fistulizing Crohn's disease resistant or intolerant to azathioprine
    • Schroder O, Blumenstein I, Schulte-Bockholt A, et al. Combining infliximab and methotrexate in fistulizing Crohn's disease resistant or intolerant to azathioprine. Alimentary Pharmacology & Therapeutics. 2004;19:295-301.
    • (2004) Alimentary Pharmacology & Therapeutics , vol.19 , pp. 295-301
    • Schroder, O.1    Blumenstein, I.2    Schulte-Bockholt, A.3
  • 15
    • 0036116379 scopus 로고    scopus 로고
    • The efficacy of methotrexate for maintaining remission in inflammatory bowel disease
    • Fraser AG, Morton D, McGovern D, et al. The efficacy of methotrexate for maintaining remission in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics. 2002;16:693-697.
    • (2002) Alimentary Pharmacology & Therapeutics , vol.16 , pp. 693-697
    • Fraser, A.G.1    Morton, D.2    McGovern, D.3
  • 16
    • 0034955615 scopus 로고    scopus 로고
    • Adverse reactions to disease-modifying anti-rheumatic drugs in clinical practice
    • Grove ML, Hassell AB, Hay EM, et al. Adverse reactions to disease-modifying anti-rheumatic drugs in clinical practice. QJM. 2001;94:309-319.
    • (2001) QJM , vol.94 , pp. 309-319
    • Grove, M.L.1    Hassell, A.B.2    Hay, E.M.3
  • 17
    • 0029069283 scopus 로고
    • Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis
    • Lafforgue P, Monjanel-Mouterde S, Durand A, et al. Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis. J Rheumatol. 1995;22:844-849.
    • (1995) J Rheumatol , vol.22 , pp. 844-849
    • Lafforgue, P.1    Monjanel-Mouterde, S.2    Durand, A.3
  • 18
    • 0033406747 scopus 로고    scopus 로고
    • A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn's disease and ulcerative colitis
    • Egan LJ, Sandborn WJ, Tremaine WJ, et al. A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn's disease and ulcerative colitis. Alimentary Pharmacology & Therapeutics. 1999;13:1597-1604.
    • (1999) Alimentary Pharmacology & Therapeutics , vol.13 , pp. 1597-1604
    • Egan, L.J.1    Sandborn, W.J.2    Tremaine, W.J.3
  • 19
    • 0037278052 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases
    • Grim J, Chladek J, Martinkova J. Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases. Clin Pharmacokinet. 2003;42:139-151.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 139-151
    • Grim, J.1    Chladek, J.2    Martinkova, J.3
  • 21
    • 0023852189 scopus 로고
    • Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia
    • Schroder H, Fogh K. Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia. Cancer Chemotherapy & Pharmacology. 1988;21:145-149.
    • (1988) Cancer Chemotherapy & Pharmacology , vol.21 , pp. 145-149
    • Schroder, H.1    Fogh, K.2
  • 22
    • 4444376725 scopus 로고    scopus 로고
    • Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
    • Dervieux T, Furst D, Lein DO, et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum. 2004;50:2766-2774.
    • (2004) Arthritis Rheum , vol.50 , pp. 2766-2774
    • Dervieux, T.1    Furst, D.2    Lein, D.O.3
  • 23
    • 0024377081 scopus 로고
    • Maintenance chemotherapy for childhood acute lymphoblastic leukemia: Relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes
    • Schmiegelow K, Schroder H, Pulczynska MK, et al. Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes. Cancer Chemotherapy & Pharmacology. 1989;25:65-69.
    • (1989) Cancer Chemotherapy & Pharmacology , vol.25 , pp. 65-69
    • Schmiegelow, K.1    Schroder, H.2    Pulczynska, M.K.3
  • 24
    • 0033023168 scopus 로고    scopus 로고
    • Methotrexate polyglutamate levels in circulating erythrocytes and polymorphs correlate with clinical efficacy in rheumatoid arthritis
    • Angelis-Stoforidis P, Vajda FJE, Christophidis N. Methotrexate polyglutamate levels in circulating erythrocytes and polymorphs correlate with clinical efficacy in rheumatoid arthritis. Clin Exp Rheumatol. 1999;17:313-320.
    • (1999) Clin Exp Rheumatol , vol.17 , pp. 313-320
    • Angelis-Stoforidis, P.1    Vajda, F.J.E.2    Christophidis, N.3
  • 25
    • 0022644286 scopus 로고
    • Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment
    • Schroder H, Clausen N, Ostergaard E, et al. Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment. Cancer Chemotherapy & Pharmacology. 1986;16:190-193.
    • (1986) Cancer Chemotherapy & Pharmacology , vol.16 , pp. 190-193
    • Schroder, H.1    Clausen, N.2    Ostergaard, E.3
  • 26
    • 0028860142 scopus 로고
    • Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology
    • Schmiegelow K, Schroder H, Gustafsson G, et al. Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology. J Clin Oncol. 1995;13:345-351.
    • (1995) J Clin Oncol , vol.13 , pp. 345-351
    • Schmiegelow, K.1    Schroder, H.2    Gustafsson, G.3
  • 27
    • 33749316892 scopus 로고    scopus 로고
    • High incidence of Crohn's disease in Canterbury, New Zealand: Results of an epidemiological study
    • Gearry RB, Richardson A, Frampton CMA, et al. High incidence of Crohn's disease in Canterbury, New Zealand: results of an epidemiological study. Inflammatory Bowel Diseases. 2006;12:936-943.
    • (2006) Inflammatory Bowel Diseases , vol.12 , pp. 936-943
    • Gearry, R.B.1    Richardson, A.2    Frampton, C.M.A.3
  • 28
    • 0017227303 scopus 로고
    • Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study
    • Best WR, Becktel JM, Singleton JW, et al. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976;70:439-444.
    • (1976) Gastroenterology , vol.70 , pp. 439-444
    • Best, W.R.1    Becktel, J.M.2    Singleton, J.W.3
  • 30
    • 0031812412 scopus 로고    scopus 로고
    • A simple clinical colitis activity index
    • Walmsley RS, Ayres RC, Pounder RE, et al. A simple clinical colitis activity index. Gut. 1998;43:29-32.
    • (1998) Gut , vol.43 , pp. 29-32
    • Walmsley, R.S.1    Ayres, R.C.2    Pounder, R.E.3
  • 31
    • 19544380606 scopus 로고    scopus 로고
    • Patient defined dichotomous end points for remission and clinical improvement in ulcerative colitis
    • Higgins PD, Schwartz M, Mapili J, et al. Patient defined dichotomous end points for remission and clinical improvement in ulcerative colitis. Gut. 2005;54:782-788.
    • (2005) Gut , vol.54 , pp. 782-788
    • Higgins, P.D.1    Schwartz, M.2    Mapili, J.3
  • 32
    • 4644295599 scopus 로고    scopus 로고
    • Influence of dietary factors on the clinical course of ulcerative colitis: A prospective cohort study
    • Jowett SL, Seal CJ, Pearce MS, et al. Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study. Gut. 2004;53:1479-1484.
    • (2004) Gut , vol.53 , pp. 1479-1484
    • Jowett, S.L.1    Seal, C.J.2    Pearce, M.S.3
  • 33
    • 0034234796 scopus 로고    scopus 로고
    • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease
    • Tibble JA, Sigthorsson G, Bridger S, et al. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology. 2000;119:15-22.
    • (2000) Gastroenterology , vol.119 , pp. 15-22
    • Tibble, J.A.1    Sigthorsson, G.2    Bridger, S.3
  • 34
    • 0141838977 scopus 로고    scopus 로고
    • HPLC determination of erythrocyte methotrexate polyglutamates after low-dose methotrexate therapy in patients with rheumatoid arthritis
    • Dervieux T, Lein DO, Marcelletti J, et al. HPLC determination of erythrocyte methotrexate polyglutamates after low-dose methotrexate therapy in patients with rheumatoid arthritis. Clin Chem. 2003;49:1632-1641.
    • (2003) Clin Chem , vol.49 , pp. 1632-1641
    • Dervieux, T.1    Lein, D.O.2    Marcelletti, J.3
  • 35
    • 0030596840 scopus 로고    scopus 로고
    • Statistics notes: Measurement error
    • Bland JM, Altman DG. Statistics notes: measurement error. BMJ. 1996;313:744.
    • (1996) BMJ , vol.313 , pp. 744
    • Bland, J.M.1    Altman, D.G.2
  • 36
    • 0010105962 scopus 로고
    • Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates
    • Allegra CJ, Drake JC, Jolivet J, et al. Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proc Natl Acad Sci U S A. 1985;82:4881-4885.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 4881-4885
    • Allegra, C.J.1    Drake, J.C.2    Jolivet, J.3
  • 37
    • 0022637441 scopus 로고
    • Inhibition of 5-aminoimidazole-4- carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide
    • Baggott JE, Vaughn WH, Hudson BB. Inhibition of 5-aminoimidazole-4- carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide. Biochem J. 1986;236:193-200.
    • (1986) Biochem J , vol.236 , pp. 193-200
    • Baggott, J.E.1    Vaughn, W.H.2    Hudson, B.B.3
  • 39
    • 23444443994 scopus 로고    scopus 로고
    • Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: Results of a multicentered cross sectional observational study
    • Dervieux T, Furst D, Lein DO, et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentered cross sectional observational study. Ann Rheum Dis. 2005;64:1180-1185.
    • (2005) Ann Rheum Dis , vol.64 , pp. 1180-1185
    • Dervieux, T.1    Furst, D.2    Lein, D.O.3
  • 40
    • 22944470530 scopus 로고    scopus 로고
    • Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis
    • Cronstein BN. Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev. 2005;57:163-172.
    • (2005) Pharmacol Rev , vol.57 , pp. 163-172
    • Cronstein, B.N.1
  • 41
    • 0027139914 scopus 로고
    • The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation
    • Cronstein BN, Naime D, Ostad E. The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J Clin Invest. 1993;92:2675-2682.
    • (1993) J Clin Invest , vol.92 , pp. 2675-2682
    • Cronstein, B.N.1    Naime, D.2    Ostad, E.3
  • 42
    • 0025827389 scopus 로고
    • Hepatic methotrexate content and progression of hepatic fibrosis: Preliminary findings
    • Ahern MJ, Kevat S, Hill W, et al. Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings. Ann Rheum Dis. 1991;50:477-480.
    • (1991) Ann Rheum Dis , vol.50 , pp. 477-480
    • Ahern, M.J.1    Kevat, S.2    Hill, W.3
  • 43
    • 0019486066 scopus 로고
    • Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug
    • Kamen BA, Nylen PA, Camitta BM, et al. Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug. Br J Haematol. 1981;49:355-360.
    • (1981) Br J Haematol , vol.49 , pp. 355-360
    • Kamen, B.A.1    Nylen, P.A.2    Camitta, B.M.3


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