The substitution U475 → C with Sabin3-like mutation within the IRES attenuate Coxsackievirus B3 cardiovirulence

Molecular Biotechnology

Volumn 36, Issue 1, 2007, Pages 52-60

  M'hadheb Gharbi, Manel Ben ^a,b   Paulous, Sylvie ^b   Aouni, Mahjoub ^a   Kean, Katherine M ^b   Gharbi, Jawhar ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b INSTITUT PASTEUR   (France)

Author keywords

Attenuation; Coxsackievirus B3; Enterovirus; IRES; Motif C; Stem loop V

Indexed keywords

GENES; NUCLEOTIDES; RNA; VACCINES; VIRUSES;

ATTENUATION PHENOTYPE; ENTEROVIRUS; POLIOVIRUS; VACCINE STRAIN;

MUTAGENESIS;

LIVE VACCINE; NUCLEOTIDE; CYTOSINE; ORAL POLIOMYELITIS VACCINE; URACIL; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS B; ENTEROVIRUS; FEMALE; GENE MUTATION; HEART DISEASE; HELA CELL; INFLAMMATION; MOUSE; NONHUMAN; VIRUS VIRULENCE; WILD TYPE; ANIMAL; CARDIOVASCULAR SYSTEM; CHEMISTRY; CONFORMATION; DEFECTIVE VIRUS; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART MUSCLE; HUMAN; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PATHOLOGY; PHENOTYPE; PROTEIN SYNTHESIS; VIROLOGY; VIRULENCE;

COXSACKIEVIRUS; ENTEROVIRUS; HUMAN POLIOVIRUS 1; MUS;

ANIMALS; BASE SEQUENCE; CARDIOVASCULAR SYSTEM; CYTOSINE; DEFECTIVE VIRUSES; ENTEROVIRUS B, HUMAN; FEMALE; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; MYOCARDIUM; NUCLEIC ACID CONFORMATION; PHENOTYPE; POLIOVIRUS VACCINE, ORAL; PROTEIN BIOSYNTHESIS; RNA, VIRAL; TRANSCRIPTION, GENETIC; URACIL; VIRULENCE;

EID: 34848923049     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-007-0019-z     Document Type: Article

References (38)

1. Pallansch, M. A., & Roos, R. P. (2001). Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In D. M. Knipe & P. M. Howley (Eds.), Fields Virology. (pp. 723-775). Philadelphia, PA: Lippincott Williams & Wilkins.
2. Jackson, R. J., & Kaminski, A. (1995). Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond. RNA, 1, 985-1000.
3. Liu, Z., Carthy, C. M., Cheung, P., Bohunek, L., Wilson, J. E., McManus, B. M., & Yang, D. (1999). Structural and functional analysis of the 5′ untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants. Virology, 265, 206-217.
4. Bhattacharyya, S., & Das, S. (2005). Mapping of secondary structure of the spacer region within the 5′-untranslated region of the coxsackievirus B3 RNA: possible role of an apical GAGA loop in binding La protein and influencing internal initiation of translation. Virus Research, 108, 89-100.
5. Pelletier, J., Kaplan, G., Racaniello, V. R., & Sonenberg, N. (1988). Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5′ noncoding region. Molecular and Cellular Biology, 8, 1103-1112.
6. Pelletier, J., & Sonenberg, N. (1988). Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature, 334, 320-325.
7. Baboonian, C., Davies, M. J., Booth, J. C., McKenna, W. J. (1997). Coxsackie B viruses and human heart disease. In S. Tracy, N. M. Chapman & B. W. J. Mahy (Eds.), The coxsackie B viruses. (pp. 31-52). Berlin: Springer-Verlag.
8. Kim, K. S., Hufnagel, G., Chapman, N. M., & Tracy, S. (2001). The group B coxsackieviruses and myocarditis. Reviews in Medical Virology, 11, 355-368.
9. Galama, J. M. D. (1997). Enteroviral infections in the immunocompromised host. Reviews in Medical Microbiology, 8, 33-40.
10. Vreugdenhil, G. R., Schloot, N. C., Hoorens, A., Rongen, C., Pipeleers, D. G., Melchers, W. J. G., Roep, B. O., & Galama, J. M. D. (2000). Acute onset of type 1 diabetes mellitus after severe echovirus 9 infection: putative pathogenic pathways. Clinical Infectious Diseases, 31, 1025-1031.
11. Yoon, J. W., Austin, M., Onodera, T., & Notkins, A. L. (1979). Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. New England Journal of Medicine, 300, 1173-1179.
12. Gauntt, C. J. (2003). Introduction and historical perspective on experimental myocarditis. In L. T. Cooper Jr. (Ed.), Myocarditis: from Bench to Bedside. (pp. 1-22). Totowa, NJ: Humana Press.
13. Ramsingh, A. I., Chapman, N., & Tracy, S. (1997). Coxsackieviruses and diabetes. Bioessays, 19, 793-800.
14. Hyöty, H., & Taylor, K. W. (2002). The role of viruses in human diabetes. Diabetologia, 45, 1353-1361.
15. Horwitz, M. S., Bradley, L. M., Harbertson, J., Krahl, T., Lee, J., & Sarvetnick, N. (1998). Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nature Medicine, 4, 781-785.
16. See, D. M., & Tilles, J. G. (1995). Pathogenesis of virus-induced diabetes in mice. Journal of Infectious Diseases, 171, 1131-1138.
17. Tracy, S., Drescher, K. M., Chapman, N. M., Kim, K. S., Carson, S. D., Pirruccello, S., Lane, P. H., Romero, J. R., & Leser, J. S. (2002). Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence. Journal of Virology, 76, 12097-12111.
18. Sabin, A. B. (1995). Oral poliovirus vaccine. History of its development and prospects for eradication of poliomyelitis. JAMA, 194, 872-876.
19. Malnou, C. E., & Kean, K. M. (2003). Translational control of poliovirus gene expression: a seductive model of disease eradication? Current Topics in Virology (in press).
20. La Monica, N., & Racaniello, V. R. (1989). Differences in replication of attenuated and neurovirulent polioviruses in human neuroblastoma cell line SH-SY5Y. Journal of Virology, 63, 2357-2560.
21. Macadam, A. J., Ferguson, G., Burlison, J., Stone, D., Skuce, R., Almond, J. W., & Minor, P. D. (1992). Correlation of RNA secondary structure and attenuation of Sabin vaccine strains of poliovirus in tissue culture. Virology, 189, 415-422.
22. MacAdam, A. J., Pollard, S. R., Ferguson, G., Skuce, R., Wood, D., Almond, J. W., & Minor, P. D. (1993). Genetic basis of attenuation of the Sabin type 2 vaccine strain of poliovirus in primates. Virology, 192, 18-26.
23. Svitkin, Y. V., Cammack, N., Minor, P. D., & Almond, J. W. (1990). Translation deficiency of the Sabin type 3 poliovirus genome: association with an attenuating mutation C472-U. Virology, 175, 103-109.
24. Ben M'hadheb-Gharbi, M., Gharbi, J., Paulous, S., Brocard, M., Komarova, A., Aouni, M., & Kean, M. K. (2006). Effects of the Sabin-like mutations in domain V of the internal ribosome entry segment on translational efficiency of the Coxsackievirus B3. Molecular Genetics and Genomics, 276, 402-412.
25. Teterina, N. L., Kean, M. K., Gorbalenya, A. E., Agol, V. I., & Girard, M. (1992). Analysis of the functional significance of amino acid residues in the putative NTP-binding pattern of the poliovirus 2C protein. The Journal of General Virology, 73, 1977-1986.
26. Malnou, E. C., Werner, A., Borman, M. A., Westhof, E., & Kean, M. K. (2004). Effects of vaccine strain mutations in domain V of the internal ribosome entry segment compared in the wild type poliovirus type 1 context. The Journal of Biological Chemistry, 279, 10261-10269.
27. Gharbi, J., El Hiar, R., Ben M'hadheb, M., Jaïdane, H., Bouslama, L., N'saïbia, S., & Aouni, M. (2006). Nucleotide sequences of IRES domains IV and V of natural ECHO virus type 11 isolates with different replication capacity phenotypes. Virus Genes, 32, 269-276.
28. Jackson, R. J., & Hunt, T. (1983). Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA. Methods in Enzymology, 96, 50-74.
29. Borman, A. M., Deliat, F. G., & Kean, K. M. (1994). Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis. The EMBO Journal, 13, 3149-3159.
30. Tu, Z., Chapman, M. N., Hufnagel, G., Tracy, S., Romero, J. R., Barry, W. H., Zhao, L., Currey, K., & Shapiro, B. (1995). The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5′ nontranslated region. Journal of Virology, 69, 4607-4618.
31. Zuker, M., Mathews, D. H., & Turner, D. H. (1999). Algorithms and thermodynamics for RNA secondary structure prediction: A practical guide. In J. Barciszewski, & B. F. C. Clark (Eds.), RNA Biochemistry and Biotechnology, NATO ASI Series, Kluwer Academic Publishers.
32. Agol, V. I. (2002). Picornavirus genome: an overview. In B. L. Semler & E. Wimmer (Eds.), Molecular biology of picornaviruses. (pp. 127-148).Washington DC: ASM Press.
33. Hellen, C. U., & Wimmer, E. (1995). Enterovirus genetics. In H. A. Rotbart (Ed.), Human Enterovirus Infection (pp. 25-72). Washington DC: American Society for Microbiology.
34. Gromeier, M., & Nomoto, A. (2002). Determinants of poliovirus pathogenesis. In B. L. Semler, & E. Wimmer (Eds.), Molecular biology of picornavirus (pp. 367-379). Washington DC: ASM Press.
35. Wimmer, E., Hellen, C. U. T., & Cao, X. M. (1993). Genetics of poliovirus. Annual Review of Genetics, 27, 353-436.
36. Malnou, C. E., Poyry, T. A. A., Jackson, R. J., & Kean. K. M. (2002). Poliovirus internal ribosome entry segment structure alterations that specifically affect function in neuronal cells: molecular genetic analysis. Journal of Virology, 76, 10617-10626.
37. Belsham, G. J., & Sonenberg, N. (1996). RNA-protein interactions in regulation of picornavirus RNA translation. Microbiological Reviews, 60, 499-511.
38. Hunt, S. L., & Jackson, R. J. (1999). Polypyrimidine-tract-binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA. RNA, 5, 344-359.