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674137 Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and upregulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. Xu Q, Takekida S, Ohara N, Chen W, Sitruk-Ware R, Johansson EDB, Maruo T J CLIN ENDOCRINOL METAB 2005 90 2 953-961
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674146 Effect of a 17α-(3-hydroxypropyl)-17β- acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11β-arylestra-4,9-dien-3-ones. Cook CE, Raje P, Lee DY, Kepler JA ORG LETT 2001 3 7 1013-1016
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674147 A practical large-scale synthesis of 17α-acetoxy- 11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4, 9-diene-3,20-dione (CDB-2914). Rao PN, Acosta CK, Bahr ML, Burdett JE, Cessac JW, Morrison PA, Kim HK STEROIDS 2000 65 7 395-400
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674148 Circulating concentrations of the antiprogestins CDB-2914 and mifepristone in the female rhesus monkey following various routes of administration. Larner JM, Reel JR, Blye RP HUM REPROD 2000 15 5 1100-1106
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674149 A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women. Stratton P, Hartog B, Hajizadeh N, Piquion J, Sutherland D, Merino M, Lee YJ, Nieman LK HUM REPROD 2000 15 5 1092-1099
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674150 CDB-2914: Anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits. Hild SA, Reel JR, Hoffman LH, Blye RP HUM REPROD 2000 15 4 822-829 • A preclinical study clearly demonstrating the antifertility and postcoital contraceptive effectiveness of ulipristal in rats and rabbits.
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674161 Effects of two antiprogestins on early pregnancy in the longtailed macaque (Macaca fascicularis). Tarantal AF, Hendrickx AG, Matlin SA, Lasley BL, Gu QQ, Thomas CA, Vince PM, Van Look PF CONTRACEPTION 1996 54 2 107-115
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674164 The anti-progestin CDB 2914 has no antifertility effect in male rats. Wang C, Sinha-Hikim A, Leung A CONTRACEPTION 1995 51 3 215-218
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674166 A comparison of the pregnancy-terminating potencies of three anti-progestins in guinea-pigs, and the effects of sulprostone. Poyser NL, Forcelledo ML PROSTAG LEUKOT ESSENT FATTY ACIDS 1994 50 5 245-247
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674166 A comparison of the pregnancy-terminating potencies of three anti-progestins in guinea-pigs, and the effects of sulprostone. Poyser NL, Forcelledo ML PROSTAG LEUKOT ESSENT FATTY ACIDS 1994 50 5 245-247
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674401 Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells. Xu Q, Ohara N, Chen W, Liu J, Sasaki H, Morikawa A, Sitruk-Ware R, Johansson ED, Maruo T HUM REPROD 2006 21 9 2408-2416
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674401 Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells. Xu Q, Ohara N, Chen W, Liu J, Sasaki H, Morikawa A, Sitruk-Ware R, Johansson ED, Maruo T HUM REPROD 2006 21 9 2408-2416
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749360 HRA begins US phase III trial of emergency contraceptive. HRA Pharma PRESS RELEASE 2006 December 07
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749360 HRA begins US phase III trial of emergency contraceptive. HRA Pharma PRESS RELEASE 2006 December 07
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778062 HRA starts pivotal emergency contraception phase III trial of Ella. HRA Pharma PRESS RELEASE 2007 March 26
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778062 HRA starts pivotal emergency contraception phase III trial of Ella. HRA Pharma PRESS RELEASE 2007 March 26
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778205 Progesterone receptor modulator for emergency contraception, A randomized controlled trial. Creinin MD, Schlaff W, Archer DF, Wan L, Frezieres R, Thomas M, Rosenberg M, Higgins J OBSTET GYNECOL 2006 108 5 1089-1097 • A phase II trial comparing the emergency contraceptive efficacy of ulipristal with that of levonorgestrel. Ulipristal was at least as effective as levonorgestrel
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778205 Progesterone receptor modulator for emergency contraception - A randomized controlled trial. Creinin MD, Schlaff W, Archer DF, Wan L, Frezieres R, Thomas M, Rosenberg M, Higgins J OBSTET GYNECOL 2006 108 5 1089-1097 • A phase II trial comparing the emergency contraceptive efficacy of ulipristal with that of levonorgestrel. Ulipristal was at least as effective as levonorgestrel.
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787580 Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. Wu Y, Guo SW GYNECOL OBSTET INVEST 2006 62 4 193-205
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787580 Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. Wu Y, Guo SW GYNECOL OBSTET INVEST 2006 62 4 193-205
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819829 Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas. Maruo T, Ohara N, Matsuo H, Xu Q, Chen W, Sitruk-Ware R, Johansson ED CONTRACEPTION 2007 75 6 Suppl 99-103
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819829 Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas. Maruo T, Ohara N, Matsuo H, Xu Q, Chen W, Sitruk-Ware R, Johansson ED CONTRACEPTION 2007 75 6 Suppl 99-103
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822355 The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata. Williams ARW, Critchley HOD, Osei J, Ingamells S, Cameron IT, Han C, Chwalisz K HUM REPROD 2007 22 6 1696-1704
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822355 The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata. Williams ARW, Critchley HOD, Osei J, Ingamells S, Cameron IT, Han C, Chwalisz K HUM REPROD 2007 22 6 1696-1704
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822389 HRA Pharma: Product pipeline. HRA Pharma COMPANY WORLD WIDE WEB SITE 2006 September 21
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822593 NCT00290251: Treatment of uterine fibroids with the selective progesterone receptor modulator CDB-2914. National Institutes of Health Clinical Center CLINICALTRIALS.GOV 2007 August 02
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822593 NCT00290251: Treatment of uterine fibroids with the selective progesterone receptor modulator CDB-2914. National Institutes of Health Clinical Center CLINICALTRIALS.GOV 2007 August 02
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822892 Product research and development: Female contraceptives. Population Council COMPANY WORLD WIDE WEB SITE 2007 August 13
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822906 Selective progesterone receptor modulators and progesterone antagonists: Mechanisms of action and clinical applications. Chabbert-Buffet N, Meduri G, Bouchard P, Spitz IM HUM REPROD UPDATE 2005 11 3 293-307
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822906 Selective progesterone receptor modulators and progesterone antagonists: Mechanisms of action and clinical applications. Chabbert-Buffet N, Meduri G, Bouchard P, Spitz IM HUM REPROD UPDATE 2005 11 3 293-307
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823531 The selective progesterone receptor modulator CDB-2914 has estrogenic and anti-estrogenic effects in menopausal women. Christian R, Stratton P, Merino MJ, Segar J, Wesley R, Barnhart L, Nieman LK ANN MEET ENDOCRINE SOC 2002 84 Abs 3-38
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823531 The selective progesterone receptor modulator CDB-2914 has estrogenic and anti-estrogenic effects in menopausal women. Christian R, Stratton P, Merino MJ, Segar J, Wesley R, Barnhart L, Nieman LK ANN MEET ENDOCRINE SOC 2002 84 Abs 3-38
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826267 Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Chwalisz K, Perez MC, Demanno D, Winkel C, Schubert G, Elger W ENDOCR REV 2005 26 3 423-438
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826267 Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Chwalisz K, Perez MC, Demanno D, Winkel C, Schubert G, Elger W ENDOCR REV 2005 26 3 423-438
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826268 Review of medical abortion using mifepristone in combination with a prostaglandin analogue. Fiala C, Gemzel-Danielsson K CONTRACEPTION 2006 74 1 66-86
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826268 Review of medical abortion using mifepristone in combination with a prostaglandin analogue. Fiala C, Gemzel-Danielsson K CONTRACEPTION 2006 74 1 66-86
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826269 A novel estrogen-free oral contraceptive pill for women: Multicentre, double-blind, randomized controlled trial of mifepristone and progestogen-only pill levonorgestrel, Lakha F, Ho PC, Van der Spuy ZM, Dada K, Elton R, Glasier AF, Critchley HO, Williams AR, Baird DT HUM REPROD 2007 22 9 2428-2436
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826269 A novel estrogen-free oral contraceptive pill for women: Multicentre, double-blind, randomized controlled trial of mifepristone and progestogen-only pill (levonorgestrel). Lakha F, Ho PC, Van der Spuy ZM, Dada K, Elton R, Glasier AF, Critchley HO, Williams AR, Baird DT HUM REPROD 2007 22 9 2428-2436
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826270 Anti-progestins suppress the growth of established tumors induced by 7,12-dimethylbenz(a)anthracene: Comparison between RU486 and a new 21-substituted-19-nor-progestin. Wiehle RD, Christov K, Mehta R ONCOL REP 2007 18 1 167-174
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826270 Anti-progestins suppress the growth of established tumors induced by 7,12-dimethylbenz(a)anthracene: Comparison between RU486 and a new 21-substituted-19-nor-progestin. Wiehle RD, Christov K, Mehta R ONCOL REP 2007 18 1 167-174
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827064 NCT00411684: Safety and efficacy of CDB-2914 for emergency contraception. HRA Pharma CLINICALTRIALS.GOV 2006 December 13
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827064 NCT00411684: Safety and efficacy of CDB-2914 for emergency contraception. HRA Pharma CLINICALTRIALS.GOV 2006 December 13
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827065 NCT00089414: The treatment of menstrually-related mood disorders with extended versus interrupted oral contraceptives. National Institutes of Health CLINICALTRIALS.GOV 2007 June 27
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827065 NCT00089414: The treatment of menstrually-related mood disorders with extended versus interrupted oral contraceptives. National Institutes of Health CLINICALTRIALS.GOV 2007 June 27
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827278 Mifepristone (RU 486) for Alzheimer's disease. Pomara N, Doraiswamy PM, Tun H, Ferris S NEUROLOGY 2002 58 9 1436
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827278 Mifepristone (RU 486) for Alzheimer's disease. Pomara N, Doraiswamy PM, Tun H, Ferris S NEUROLOGY 2002 58 9 1436
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827286 Alterations in the pituitary-thyroid and pituitary-adrenal, axesconsequences of long-term mifepristone treatment. Heikinheimo O, Ranta S, Grunberg S, Lähteenmäki P, Spitz IM METABOLISM 1997 46 3 292-296
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827286 Alterations in the pituitary-thyroid and pituitary-adrenal - axesconsequences of long-term mifepristone treatment. Heikinheimo O, Ranta S, Grunberg S, Lähteenmäki P, Spitz IM METABOLISM 1997 46 3 292-296
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827291 Alterations in sex steroids and gonadotropins in postmenopausal women subsequent to long-term mifepristone administration. Heikinheimo O, Ranta S, Grunberg S, Spitz IM STEROIDS 2000 65 10-11 831-836
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827291 Alterations in sex steroids and gonadotropins in postmenopausal women subsequent to long-term mifepristone administration. Heikinheimo O, Ranta S, Grunberg S, Spitz IM STEROIDS 2000 65 10-11 831-836
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827293 Long-term mifepristone (RU486) therapy resulting in massive benign endometrial hyperplasia. Newfield RS, Spitz IM, Isacson C, New MI CLIN ENDOCRINOL 2001 54 3 399-404
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827293 Long-term mifepristone (RU486) therapy resulting in massive benign endometrial hyperplasia. Newfield RS, Spitz IM, Isacson C, New MI CLIN ENDOCRINOL 2001 54 3 399-404
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827318 Drug development pipeline: Ulipristal/CDB-2914/Ella. HRA Pharma COMPANY COMMUNICATION 2007 August 30
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