Febrile temperatures control antineutrophil cytoplasmic autoantibody-induced neutrophil activation via inhibition of phosphatidylinositol 3-kinase/Akt

Arthritis and Rheumatism

Volumn 56, Issue 9, 2007, Pages 3149-3158

  Von Vietinghoff, Sibylle ^a   Choi, Mira ^a   Rolle, Susanne ^a   Luft, Friedrich C ^a   Kettritz, Ralph ^a,b  

^a Franz Volhard Klinik   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GRANULOCYTE COLONY STIMULATING FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; NITROBLUE TETRAZOLIUM; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEINASE; RHODAMINE; TUMOR NECROSIS FACTOR;

ANCA ASSOCIATED VASCULITIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEVER; FLUORESCENCE; HIGH TEMPERATURE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE ACTIVATION; NEUTROPHIL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY BURST; SIGNAL TRANSDUCTION; TEMPERATURE DEPENDENCE; THERMAL EXPOSURE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEVER; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; NEUTROPHIL ACTIVATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RESPIRATORY BURST; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34848894606     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22832     Document Type: Article

References (33)

1. Van der Woude FJ. Anticytoplasmic antibodies in Wegener's granulomatosis. Lancet 1985;2:48.
2. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988;318:1651-7.
3. Falk RJ, Terrell RS, Charles LA, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 1990;87:4115-9.
4. Reumaux D, Vossebeld PJ, Roos D, Verhoeven AJ. Effect of tumor necrosis factor-induced integrin activation on Fcγ receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. Blood 1995;86:3189-95.
5. Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S, et al. Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood 2005;106:2050-8.
6. Woywodt A, Streiber F, de Groot K, Regelsberger H, Haller H, Haubitz M. Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet 2003;361:206-10.
7. Porges AJ, Redecha PB, Kimberly WT, Csernok E, Gross WL, Kimberly RP. Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fcγ RIIa. J Immunol 1994;153:1271-80.
8. Kettritz R, Falk RJ, Jennette JC, Gaido ML. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNFα-mediated apoptosis. J Am Soc Nephrol 1997;8:1091-100.
9. Hewins P, Williams JM, Wakelam MJ, Savage CO. Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcγ receptors and CD18. J Am Soc Nephrol 2004;15:796-808.
10. 2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG. J Am Soc Nephrol 2003;14:661-9.
11. Sibelius U, Hattar K, Schenkel A, Noll T, Csernok E, Gross WL, et al. Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response. J Exp Med 1998;187:497-503.
12. Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Maeda N, et al. The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol 2005;167:39-45.
13. Radford DJ, Lord JM, Savage COS. The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation. Clin Exp Immunol 1999;118:171-9.
14. Kettritz R, Schreiber A, Luft FC, Haller H. Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. J Am Soc Nephrol 2001;12:37-46.
15. Ben-Smith A, Dove SK, Martin A, Wakelam MJ, Savage CO. Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcγ receptor ligation. Blood 2001;98:1448-55.
16. Kettritz R, Choi M, Butt W, Rane M, Rolle S, Luft FC, et al. Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils. J Am Soc Nephrol 2002;13:1740-9.
17. Salanova B, Choi M, Rolle S, Wellner M, Scheidereit C, Luft FC, et al. The effect of fever-like temperatures on neutrophil signaling. FASEB J 2005;19:816-8.
18. Kettritz R, Choi M, Salanova B, Wellner M, Rolle S, Luft FC. Fever-like temperatures affect neutrophil NF-κB signaling, apoptosis, and ANCA-antigen expression. J Am Soc Nephrol 2006;17:1345-53.
19. Brandts CH, Ndjave M, Graninger W, Kremsner PG. Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. Lancet 1997;350:704-9.
20. Jiang Q, Cross AS, Singh IS, Chen TT, Viscardi RM, Hasday JD. Febrile core temperature is essential for optimal host defense in bacterial peritonitis. Infect Immun 2000;68:1265-70.
21. Kluger MJ, Kozak W, Conn CA, Leon LR, Soszynski D. Role of fever in disease. Ann N Y Acad Sci 1998;856:224-33.
22. Jayne D, Rasmussen N, Andrassy K, Bacon P, Tervaert JW, Dadoniene J, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 2003;349:36-44.
23. Wegener's Granulomatosis Etanercept Trial (WGET) Research Group. Etanercept plus standard therapy for Wegener's granulomatosis. N Engl J Med 2005;352:351-61.
24. Baehner RL, Nathan DG. Quantitative nitroblue tetrazolium test in chronic granulomatous disease. N Engl J Med 1968;278:971-6.
25. Xiao H, Heeringa P, Hu P, Liu Z, Zhao M, Aratani Y, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002;110:955-63.
26. Pfister H, Ollert M, Froehlich LF, Quintanilla-Martinez L, Colby TV, Specks U, et al. Anti-neutrophil cytoplasmic autoantibodies (ANCA) against the murine homolog of proteinase 3 (Wegener's autoantigen) are pathogenic in vivo. Blood 2004;104:1411-8.
27. Hellmich B, Csernok E, Trabandt A, Gross WL, Ernst M. Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro. Clin Exp Immunol 2000;120:392-8.
28. Hewins P, Morgan MD, Holden N, Neil D, Williams JM, Savage CO, et al. IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis. Kidney Int 2006;69:605-15.
29. Choi M, Rolle S, Wellner M, Cardoso MC, Scheidereit C, Luft FC, et al. Inhibition of NF-κB by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis. Blood 2003;102:2259-67.
30. Harper L, Cockwell P, Adu D, Savage CO. Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Kidney Int 2001;59:1729-38.
31. Harper L, Ren Y, Savill J, Adu D, Savage CO. Antineutrophil cytoplasmic antibodies induce reactive oxygen-dependent dysregulation of primed neutrophil apoptosis and clearance by macrophages. Am J Pathol 2000;157:211-20.
32. Moosig F, Csernok E, Kumanovics G, Gross WL. Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-α (TNF-α). Clin Exp Immunol 2000;122:499-503.
33. Chu EK, Ribeiro SP, Slutsky AS. Heat stress increases survival rates in lipopolysaccharide-stimulated rats. Crit Care Med 1997;25:1727-32.