Effect of glutamine supplementation on splanchnic metabolism in lactating dairy cows

Journal of Dairy Science

Volumn 90, Issue 9, 2007, Pages 4325-4333

  Doepel, L ^a,e   Lobley, G E ^b   Bernier, J F ^a   Dubreuil, P ^c   Lapierre, H ^d  

^a UNIVERSITÉ LAVAL   (Canada)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d SHERBROOKE RESEARCH AND DEVELOPMENT CENTRE   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Amino acid; Glutamine; Nutrient flux; Splanchnic

Indexed keywords

BOS;

AMINO ACID; GLUCOSE; GLUTAMINE; MILK PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; CATTLE; CHEMISTRY; DIET; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; GLUCONEOGENESIS; LACTATION; LIVER; METABOLISM; MILK; NUTRITIONAL REQUIREMENT; OXYGEN CONSUMPTION; PHYSIOLOGY; PUERPERIUM; SPLANCHNIC BLOOD FLOW; UDDER; VISCERA;

AMINO ACIDS; ANIMALS; CATTLE; DIET; DIETARY SUPPLEMENTS; FEMALE; GLUCONEOGENESIS; GLUCOSE; GLUTAMINE; LACTATION; LIVER; MAMMARY GLANDS, ANIMAL; MILK; MILK PROTEINS; NUTRITIONAL REQUIREMENTS; OXYGEN CONSUMPTION; POSTPARTUM PERIOD; SPLANCHNIC CIRCULATION; VISCERA;

EID: 34848826056     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2007-0124     Document Type: Article

References (51)

1. AOAC. 1996. Official Methods of Analysis. 16th ed. Association of Official Analytical Chemists, Arlington, VA.
2. Bach, A., G. B. Huntington, S. Calsamiglia, and M. D. Stern. 2000. Nitrogen metabolism of early lactation cows fed diets with two different levels of protein and different amino acid profiles. J. Dairy Sci. 83:2585-2595.
3. Bartels, H., and H. Harms. 1959. Sauerstoffdissoziationskurven des blutes von saügetieren. Pflugers Arch. 268:S334-S365.
4. Bell, A. W. 1995. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. J. Anim. Sci. 73:2804-2819.
5. Benson, J. A., C. K. Reynolds, P. C. Aikman, B. Lupoli, and B. E. Beever. 2002. Effects of abomasal long chain fatty acid infusion on splanchnic nutrient metabolism in lactating dairy cows. J. Dairy Sci. 85:1804-1814.
6. Bequette, B. J., F. R. C. Backwell, J. C. MacRae, G. E. Lobley, L. A. Crompton, J. A. Metcalf, and J. D. Sutton. 1996. Effect of intravenous amino acid infusion on leucine oxidation across the mammary gland of the lactating goat. J. Dairy Sci. 79:2217-2224.
7. Bequette, B. J., N. E. Sunny, S. W. El-Kadi, and S. L. Owens. 2006. Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients. J. Anim. Sci. 2006. 84(E. Suppl.):E50-E59.
8. Bergmeyer, H. U., and H. A. Beutler. 1985. Ammonia. Pages 454-461 in Methods of Enzymatic Analysis. 3rd ed. Vol. VIII. H. U. Bergmeyer, J. Bergmeyer, and M. Grassl, ed. Verlag Chemie, Deerfield Beach, FL.
9. Berthiaume, R., P. Dubreuil, M. Stevenson, B. W. McBride, and H. Lapierre. 2001. Intestinal disappearance and mesenteric and portal appearance of amino acids in dairy cows fed ruminally protected methionine. J. Dairy Sci. 84:194-203.
10. Berthiaume, R., M. C. Thivierge, R. A. Patton, P. Dubreuil, M. Stevenson, B. W. McBride, and H. Lapierre. 2006. Effect of ruminally protected methionine on splanchnic metabolism of amino acids in lactating dairy cows. J. Dairy Sci. 89:1621-1634.
11. Blouin, J. P., J. F. Bernier, C. K. Reynolds, G. E. Lobley, P. Dubreuil, and H. Lapierre. 2002. Effect of supply of metabolizable protein on splanchnic fluxes of nutrients and hormones in lactating dairy cows. J. Dairy Sci. 85:2618-2630.
12. Borucki Castro, S. I., L. E. Phillip, H. Lapierre, P. W. Jardon, and R. Berthiaume. 2007. Ruminal degradability and intestinal digestibility of protein and amino acids in treated soybean meal products. J. Dairy Sci. 90:810-822.
13. 13C amino acids as internal standards. Rapid Commun. Mass Spectrom. 13:2080-2083.
14. Canadian Council on Animal Care. 1993. Guide to the Care and Use of Experimental Animals. Vol. 1. 2nd ed. E. D. Olfert, B. M. Cross, and A. A. McWilliam, ed. CCAC, Ottawa, Ontario, Canada.
15. Cant, J. P., E. J. DePeters, and R. L. Baldwin. 1993. Mammary amino acid utilization in dairy cows fed fat and its relationship to milk protein depression. J. Dairy Sci. 76:762-774.
16. Doepel, L., H. Lapierre, and J. J. Kennelly. 2002. Peripartum performance and metabolism of dairy cows in response to prepartum energy and protein intake. J. Dairy Sci. 85:2315-2334.
17. Doepel, L., M. Lessard, N. Gagnon, G. E. Lobley, J. F. Bernier, P. Dubreuil, and H. Lapierre. 2006. Effect of glutamine supplementation on immune response and milk production in dairy cows. J. Dairy Sci. 89:3107-3121.
18. El-Kadi, S. W., R. L. Baldwin VI, N. E. Sunny, S. L. Owens, and B. J. Bequette. 2006. Intestinal protein supply alters amino acid, but not glucose, metabolism by the sheep gastrointestinal tract J. Nutr. 136:1261-1269.
19. Gate, J. J., D. S. Parker, and G. E. Lobley. 1999. The metabolic fate of the amido-N group of glutamine in the tissues of the gastrointestinal tract in 24 h-fasted sheep. Br. J. Nutr. 81:297-306.
20. Gibb, M. J., W. E. Ivings, M. S. Dhanoa, and J. D. Sutton. 1992. Changes in body components of autumn-calving Holstein-Friesian cows over the first 29 weeks of lactation. Anim. Prod. 55:339-360.
21. Guinard, J., and H. Rulquin. 1994. Effects of graded amounts of duodenal infusions of lysine on the mammary uptake of major milk precursors in dairy cows. J. Dairy Sci. 77:3565-3576.
22. Hanigan, M. D., C. K. Reynolds, D. J. Humphries, B. Lupoli, and J. D. Sutton. 2004. A model of net amino acid absorption and utilization by the portal-drained viscera of the lactating dairy cow. J. Dairy Sci. 87:4247-4268.
23. Hoskin, S. O., S. Gavet, E. Milne, and G. E. Lobley. 2001. Does glutamine act as a substrate for transamination reactions in the liver of fed and fasted sheep? Br. J. Nutr. 85:591-597.
24. Huntington, G. B. 1984. Net absorption of glucose and nitrogenous compounds by lactating Holstein cows. J. Dairy Sci. 67:1919-1927.
25. Huntington, G. B., C. K. Reynolds, and B. H. Stroud. 1989. Techniques for measuring blood flow in splanchnic tissues of cattle. J. Dairy Sci. 72:1583-1595.
26. Jensen, R. G. 1995. Handbook of Milk Composition. R. G. Jensen, ed. Academic Press, Toronto, Ontario, Canada.
27. Katz, M. L., and E. N. Bergman. 1969. Simultaneous measurements of hepatic and portal venous blood flow in the sheep and dog. Am. J. Physiol. 216:946-952.
28. Lapierre, H., R. Berthiaume, G. Raggio, M. C. Thivierge, L. Doepel, D. Pacheco, P. Dubreuil, and G. E. Lobley. 2005. The route of absorbed nitrogen into milk protein. Anim. Sci. 80:11-22.
29. Lapierre, H., E. Milne, J. Renaud, and G. E. Lobley. 2003. Lysine utilization by the mammary gland. Pages 777-780 in Progress in Research on Energy and Protein Metabolism. W. B. Souffrant and C. C. Metges, ed. EAAP Publication No. 109. Wageningen Academic Publishers, Wageningen, the Netherlands.
30. Lobley, G. E., D. M. Bremner, and D. S. Brown. 2001. Response in hepatic removal of amino acids by the sheep to short term infusions of various amounts of an amino acid mixture into the mesenteric vein. Br. J. Nutr. 85:689-698.
31. Lobley, G. E., and H. Lapierre. 2003. Post-absorptive metabolism of amino acids. Pages 737-753 in Progress in Research on Energy and Protein Metabolism. W. B. Souffrant and C. C. Metges, ed. EAAP Publication No. 109. Wageningen Academic Publishers, Wageningen, the Netherlands.
32. Meijer, A. J. 1985. Channeling of ammonia from glutaminase to carbamoyl-phosphate synthetase in liver mitochondria. FEBS Lett. 191:249-251.
33. Meijer, G. A. L., H. de Visser, J. van der Meulen, C. J. van der Koelen, and A. Klop. 1995a. Effect of glutamine or propionate infused into the abomasum on milk yield, milk composition, nitrogen retention and net flux of amino acids across the udder of high yielding dairy cows. Pages 157-160 in Proc. Seventh Symp. Protein Metabolism and Nutrition. A. F. Nunes, A. V. Portugal, J. P. Costa, and J. R. Ribeiro, ed. Estacoa Zootechnica National, Santerm, Portugal.
34. Meijer, G. A. L., J. van der Meulen, J. G. M. Bakker, C. J. Van der Koelen, and A. M. van Vuuren. 1995b. Free amino acids in plasma and muscle of high yielding dairy cows in early lactation. J. Dairy Sci. 78:1131-1141.
35. Meijer, G. A. L., J. van der Meulen, and A. M. van Vuuren. 1993. Glutamine is a potentially limiting amino acid for milk production in dairy cows: A hypothesis. Metabolism 42:358-364.
36. Mepham, T. B. 1982. Amino acid utilization by lactating mammary gland. J. Dairy Sci. 65:287-298.
37. Milano, G. D., A. Hotston-Moore, and G. E. Lobley. 2000. Influence of hepatic ammonia removal on ureagenesis, amino acid utilization and energy metabolism in the ovine liver. Br. J. Nutr. 83:307-315.
38. Newsholme, P. 2001. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J. Nutr. 131:2515S-2522S.
39. Nieto, R., T. Obitsu, A. Fernandez-Quitaela, D. Bremner, E. Milne, A. G. Calder, and G. E. Lobley. 2002. Glutamine metabolism in ovine splanchnic tissues: Effects of infusion of ammonium bicarbonate or amino acids into the abomasum. Br. J. Nutr. 87:357-366.
40. Oba, M., R. L. Baldwin, and B. J. Bequette. 2004. Oxidation of glucose, glutamate, and glutamine by isolated ovine enterocytes in vitro is decreased by presence of other metabolic fuels. J. Anim. Sci. 82:479-486.
41. Okine, E. K., D. R. Glimm, J. R. Thompson, and J. J. Kennelly. 1995. Influence of stage of lactation on glucose and glutamine metabolism in isolated enterocytes from dairy cattle. Metabolism 44:325-331.
42. Pacheco-Rios, D., W. C. McNabb, S. Cridland, T. N. Barry, and J. Lee. 1998. Arterio-venous differences of amino acids across the mammary gland of cows fed fresh-pasture at two levels of dry matter intake during early lactation. Proc. N.Z. Soc. Anim. Prod. 58:98-101.
43. Raggio, G., D. Pacheco, R. Berthiaume, G. E. Lobley, D. Pellerin, G. Allard, P. Dubreuil, and H. Lapierre. 2004. Effect of level of metabolizable protein on splanchnic flux of amino acids in lactating dairy cows. J. Dairy Sci. 87:3461-3472.
44. Reeds, P. J., D. G. Burrin, B. Stoll, and F. Jahoor. 2000. Intestinal glutamate metabolism. J. Nutr. 130.-978S-982S.
45. Reynolds, C. K. 1992. Metabolism of nitrogenous compounds by ruminant liver. J. Nutr. 122:850-854.
46. SAS Institute. 1999. SAS System for Mixed Models. SAS Institute Inc., Cary, NC.
47. Stoll, B., D. G. Burrin, J. Henry, H. Yu, F. Jahorr and P. J. Reeds. 1999. Substrate oxidation by the portal drained viscera of fed piglets. Am. J. Physiol. 277 (Endocrinol. Metab. 40):E168-E175.
48. Thivierge, M. C., D. Petitclerc, J. F. Bernier, Y. Couture, and H. Lapierre. 2002. Variations in mammary metabolism during the natural filling of the udder with milk over a 12-h period between two milkings J. Dairy Sci. 85:1839-1854.
49. van der Schoor, S. R. D., J. B. Van Goudoever, B. Stoll, J. F. Henry, J. R. Rosenberger, D. G. Burrin, and P. J. Reeds. 2001. The pattern of intestinal substrate oxidation is altered by protein restriction in pigs. Gastroenterology 121:1167-1175.
50. Wilmore, D. W. 2001. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J. Nutr. 131:2543S-2549S.
51. Ziegler, T. R. 2001. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J. Nutr. 131:2578S-2584S.