Keratins: Markers of cell differentiation or regulators of cell differentiation?

Journal of Biosciences

Volumn 32, Issue 4, 2007, Pages 629-634

  Vaidya, Milind M ^a   Kanojia, Deepak ^a  

^a CANCER RESEARCH INSTITUTE   (India)

Author keywords

Cell differentiation; Keratins

Indexed keywords

CELL MARKER; CYTOKERATIN 1; CYTOKERATIN 10; CYTOKERATIN 13; CYTOKERATIN 14; CYTOKERATIN 16; CYTOKERATIN 17; CYTOKERATIN 18; CYTOKERATIN 4; CYTOKERATIN 5; CYTOKERATIN 6; CYTOKERATIN 8; DIMETHYLBENZ[A]ANTHRACENE; DODECYL SULFATE SODIUM; KERATIN; MAMMALIAN TARGET OF RAPAMYCIN; PLECTIN; POLYMER; TRANSCRIPTION FACTOR;

CELL CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; GENE CONTROL; GENE MUTATION; GENE OVEREXPRESSION; HOMEOSTASIS; KERATODERMA; NONHUMAN; NOTE; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PSORIASIS; RNA TRANSLATION; SIGNAL TRANSDUCTION; SKIN CARCINOMA; SKIN PAPILLOMA; STEM CELL; WOUND;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; KERATINS;

EID: 34848819378     PISSN: 02505991     EISSN: 02505991     Source Type: Journal    
DOI: 10.1007/s12038-007-0062-8     Document Type: Note

References (38)

1. Buhler H and Schaller G 2005 Transfection of keratin 18 gene in human breast cancer cells causes induction of adhesion proteins and dramatic regression of malignancy in vitro and in vivo; Mol. Cancer Res. 3 365-371
2. Casanova M L, Bravo A, Martinez-Palacio J, Fernandez-Acenero M J, Villanueva C, Larcher F, Conti C J and Jorcano J L 2004 Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice; FASEB J. 18 1556-1568
3. Caulin C, Ware C F, Magin T M and Oshima R G 2000 Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis; J. Cell Biol. 149 17-22
4. Chen J, Cheng X, Merched-Sauvage M, Caulin C, Roop D R and Koch P J 2006 An unexpected role for keratin 10 end domains in susceptibility to skin cancer; J. Cell Sci. 119 5067-5076
5. Clausen G, Moc D, Buschard K and Dabelstein E 1986 Keratin proteins in human oral mucosa; J. Oral Pathol. 15 36-42
6. Coulombe P A and Omary M B 2002 "Hard" and "soft" principles defining the structure, function and regulation of keratin intermediate filaments; Curr. Opin. Cell Biol. 14 110-122
7. Franke W W, Schmid E and Schiller D L 1982 Differentiation related patterns of expression of proteins of intermediate filaments in tissues and cultured cells; Cold Spring Harbor Symp. Quant. Biol. 46 431-531
8. Gijbels M J, van der Ham F, van Bennekum A M, Hendriks H F and Roholl P J 1992 Alterations in cytokeratin expression precede histological changes in epithelia of vitamin A-deficient rats; Cell Tissue Res. 268 197-203
9. Gilbert S, Loranger A, Daigle N, Marceau N 2001 Simple epithelium keratins 8 and 18 provide resistance to Fasmediated apoptosis. The protection occurs through a receptor-targeting modulation; J. Cell Biol. 154 763-773
10. Gilbert S, Loranger A and Marceau N 2004 Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells; Mol. Cell Biol. 24 7072-7081
11. Hendrix M J C, Seftor E A, Chu Y W, Trevor K T and Seftor R E B 1996 Role of intermediate filaments in migration, invasion and metastasis; Cancer Metastasis Rev. 15 507-525
12. Inada H, Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, Momoi T and Inagaki M 2001 Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD; J. Cell Biol. 155 415-426
13. Kim S, Wong P and Coulombe P A 2006 A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth; Nature (London) 441 362-365
14. Ku N O, Liao J, Chou C F and Omary M.B 1996 Implications of intermediate filament protein phosphorylation; Cancer Metastasis Rev. 15 429-444
15. Ku N O, Michie S, Resurreccion E Z, Broome R L and Omary M B 2002 Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression; Proc. Natl. Acad. Sci. USA 99 4373-4378
16. Magin T M, Hesse M and Schröder R 2000 Novel insights into intermediate-filament function from studies of transgenic and knockout mice; Protoplasma 211 140-150
17. Magin T M, Reichelt J and Chen J 2005 The role of keratins in epithelial homeostasis; in Skin barrier (eds) P M Elias and K R Feingold (New york: Taylor and Francis) pp 141-170
18. Maytin E V, Lin J C, Krishnamurthy R, Batchvarova N, Ron D, Mitchell P J and Habener J F 1999 Keratin 10 expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2; Dev. Biol. 216 164-181
19. McGowan K and Coulombe P A 1998 The wound repair-associated keratins K6, K16 and K17: insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture; Subcell. Biochem. 31 173-204
20. Moll R, Franke W W, Schiller D L, Geiger B and Krepler R 1982 The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells; Cell 31 11-24
21. Omary M B, Coulombe P A and McLean W H 2004 Intermediate filament proteins and their associated diseases; N. Engl. J. Med. 351 2087-2100
22. Omary M B, Ku N O, Tao G Z, Toivola D M and Liao J 2006 "Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights; Trends Biochem. Sci. 31 383-394
23. Paladini R D and Coulombe P A 1998 Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation; J. Cell Biol. 142 1035-1051
24. Paramio J M, Segrelles C, Ruiz S and Jorcano J L 2001 Inhibition of protein kinase B (PKB) and PKC zeta mediates keratin K10-induced cell cycle arrest; Mol. Cell Biol. 21 7449-7459
25. Ranganathan K, Kavitha R, Sawant S S and Vaidya M M 2006 Cytokeratin expression in oral submucous fibrosis - an immunohistochemical study; J. Oral Pathol. Med. 35 25-32
26. Raul U B, Sawant S S, Dange P P, Kalraiya R D and Vaidya M M 2004 Implications of CK 8/18 filament formation in stratified epithelial cells: induction of transformed phenotype; Int. J. Cancer 111 662-668
27. Reichelt J and Magin T M 2002 Hyperproliferation, induction of c-Myc and 14-3-3σ, but no cell fragility in keratin-10-null mice; J. Cell Sci. 115 2639-2650
28. Roop D R, Krieg T M, Mehrel T, Cheng C K and Yuspa S H 1988 Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis; Cancer Res. 48 3245-3252
29. Santos M, Paramio J M, Bravo A, Ramirez A and Jorcano J L 2002 The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis; J. Biol. Chem. 277 19122-19130
30. Santos M, Río P, Ruiz S, Martínez-Palacio J, Segrelles C, Lara M F, Segovia J C and Paramio J M 2005 Altered T cell differentiation and notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus; J. Cell Biochem. 95 543-558
31. Swaf M H, Ouhayoum J P, Shabana A H M and Forest N 1990 Cytokeratin expression in human tongue epithelium; Am. J. Anat. 189 155-166
32. Toivola D M, Krishnan S, Binder H J, Singh S K and Omary M B 2004 Keratins modulate colonocyte electrolyte transport via protein mistargeting; J. Cell Biol. 164 911-921
33. Tong X and Coulombe P A 2006 Keratin 17 modulates hair follicle cycling in a TNFα dependent fashion; Genes Dev. 20 1353-1364
34. Vaidya M M, Borges A M, Pradhan S A and Bhisey A N 1996 Cytokeratin expression in squamous cell carcinomas of the tongue and alveolar mucosa; Eur. J. Cancer B. Oral Oncol. 32B 333-336
35. Vaidya M M, Borges A M, Pradhan S A, Rajpal R M and Bhisey A N 1989 Altered keratin expression in buccal mucosal squamous cell carcinoma; J. Oral Pathol. Med. 18 282-286
36. Vaidya M M, Sawant S S, Borges A M, Ogale S B and Bhisey A N 1998 Cytokeratin expression in precancerous lesions of the human oral cavity; Oral Oncol. 34 261-264
37. Vigneshwaran N, Peters K P, Hornstein O P and Haneke E 1989 Comparison of cytokeratin, filaggrin and involucrin profiles in oral leukoplakias and squamous carcinomas; J. Oral Pathol. Med. 18 377-390
38. Wang Y N and Chang W C 2003 Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun; J. Biol. Chem. 278 45848-45857