AgNOR count as objective marker for dysplastic features in oral leukoplakia

Journal of Oral Pathology and Medicine

Volumn 31, Issue 9, 2002, Pages 512-517

  Chattopadhyay, Amit ^a,b,d   Ray, Jay G ^c   Caplan, Daniel J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b IL   (United States)

^c DR R AHMED DENTAL COLLEGE AND HOSPITAL   (India)

^d NONE   (United States)

Author keywords

AgNOR; Leukoplakia; ROC; Sensitivity; Specificity; Squamous cell carcinoma

Indexed keywords

TUMOR MARKER;

ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; CHROMOSOME NOR; HUMAN; LEUKOPLAKIA; MOUTH MUCOSA; MOUTH TUMOR; PATHOLOGY; PRECANCER; SENSITIVITY AND SPECIFICITY; SILVER STAINING; SQUAMOUS CELL CARCINOMA; STATISTICAL MODEL;

ANALYSIS OF VARIANCE; AREA UNDER CURVE; CARCINOMA, SQUAMOUS CELL; HUMANS; LEUKOPLAKIA, ORAL; LIKELIHOOD FUNCTIONS; MOUTH MUCOSA; MOUTH NEOPLASMS; NUCLEOLUS ORGANIZER REGION; PRECANCEROUS CONDITIONS; SENSITIVITY AND SPECIFICITY; SILVER STAINING; TUMOR MARKERS, BIOLOGICAL;

EID: 0036785156     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0714.2002.00153.x     Document Type: Article

References (23)

1. Sudbo J, Bryne M, Johannessen AC, et al. Comparison of histological grading and large-scale genomic status (DNA ploidy) as prognostic tools in oral dysplasia. J Pathol 2001; 194: (July) (3): 303-10.
2. Abbey LM, Kaugars GE, Gunsolley JC, et al. The effect of clinical information on the histopathologic diagnosis of oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85: (January) (1): 74-7.
3. Abbey LM, Kaugars GE, Gunsolley JC, et al. Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 80: (August) (2): 188-91.
4. Karabulut A, Reibel J, Therkildsen MH, et al. Observer variability in the histologic assessment of oral premalignant lesions. J Oral Pathol Med 1995; 24: (May) (5): 198-200.
5. Chattopadhyay A, Chawda JG, Doshi JJ. Silver-binding nucleolar organizer regions: a study of oral leukoplakia and squamous cell carcinoma. Int. J Oral Maxillofac Surg 1994; 23: 374-7.
6. Cia EMM, Trevisan M, Metze K. Argyrophylic nucleolar organizer regions (AgNOR) technique: a helpful tool for differential diagnosis in urinary cytology. Cytopathology 1999; 10: 30-9.
7. Lelmini MV, Heber E, Schwint AE, et al. AgNORs are sensitive markers of radiation lesions in squamous epithelia. J Dent Res 2000; 79: 850-6.
8. Schwint AE, Folco A, Morales A, et al. AgNOR mark epithelial foci in malignant transformation in hamster cheek pouch carciniogenesis. J Oral Pathol Med 1996; 25: 20-4.
9. Crocker J, Skilbeck N. Nucleolar organizer region associated proteins in cutaneous melanotic lesions: a quantitative study. J Clin Pathol 1987; 40: 885-9.
10. Jan-Mohammed RM, Armstrong SJ, Crocker J. The relationship between number of interphase NORs and NOR bearing chromosomes in non-Hodgkin's lymphoma. J Pathol 1989; 158: 3-7.
11. Piffko J, Bankfalvi A, Ofner D, et al. Progniostic value of histological factors (malignancy grading and AgNOR content) assessed at the invasive tumor front of oral squamous cell carcinoma. Br J Cancer 1997a; 75: 1543-6.
12. Piffko J, Bankfalvi A, Ofner D, et al. Standardized demonstration of silver-stained nucleolar organizer regions-associated proteins in archival oral squamous cell carcinomas and adjacent non-neoplastic mucosa. Mod Pahol 1997b, 1098-104.
13. Giuffre G, Fulcheri E, Gualco M, et al. Standardized AgNOR analysis as a prognostic parameter in endometrial carcinoma, endometroid type. Anal Quant Cytol Histol 2001; 23: 31-40.
14. Tuccari G, Abbona GC, Giuffre G, et al. AgNOR quantity as a prognostic tool in hyperplastic and neoplastic parathyroid glands. Virchows Arch 2000; 437: 298-303.
15. Xie X, Nordgard S, Halvorsen TB, et al. Prognostic significance of nucleolar organizer regions in adenoid cystic carcinomas of the head and neck. Acta Otolaryngol Head Neck Surg 1997; 123: 615-20.
16. Ofner D, Aubele M, Biesterfeld S, et al. Guidelines of AgNOR quantification: first update. Virchows Arch 1995; 427: 341.
17. Zewig MH, Campbell G. Receiver operating characteristic (ROC) plots: a fundamental tool in clinical medicine. Clin Chem 1993; 39: 561-77.
18. Kraemer HC, Thiemann S. How Many Subjects? Statistical Power Analysis in Research. Newbury Park: Sage Publications, 1990.
19. Shafer WG, Hine MK, Levy BM, eds. A Textbook of Oral Pathology, 4th edn. Philadelphia: W.B. Saunders Company, 1983.
20. Hara T, Sato T, Mori S, et al. Argyrophilic nucleolar organizer regions (AgNORs) in mucosal epithelium under experimental denture bases in rats. J Oral Pathol Med 2000; 29: 33-8.
21. Kaplan I, Engelberg J, Dayan D. The effect of desalivation on 4-nitroquinolone-1-oxide-induced tongue carcinogenesis: a morphometric study of nuclear organizer regions. J Oral Pathol Med 2001; 30: 48-52.
22. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical epidemiology - a basic science for clinical medicine, 2nd edn. Boston: Little, Brown and Company, 1991.
23. Katz DL. Clinical Epidemiology and Evidence Based Medicine. Fundamental Principles of Clinical Reasoning and Research. Thousand Oaks, USA: Sage Publications, 2001.