An Eosinophil Hypothesis for Functional Dyspepsia

Clinical Gastroenterology and Hepatology

Volumn 5, Issue 10, 2007, Pages 1147-1148

  Rothenberg, Marc E ^a   Cohen, Mitchell B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; CYTOKINE; EOSINOPHIL CATIONIC PROTEIN; EOSINOPHIL PEROXIDASE; EOSINOPHIL PROTEIN X; IMMUNOGLOBULIN; MAJOR BASIC PROTEIN; PROTEIN MBP 1; PROTEIN MBP 2; SUBSTANCE P; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

BLOOD VESSEL PERMEABILITY; DEGRANULATION; DUODENUM; DYSPEPSIA; EDITORIAL; ENDOSCOPY; EOSINOPHIL; EOSINOPHILIC ESOPHAGITIS; HUMAN; INFLAMMATORY CELL; IRRITABLE COLON; NONHUMAN; PATHOGENESIS; STOMACH EMPTYING; SYMPTOMATOLOGY; TARGET CELL;

DUODENUM; DYSPEPSIA; EOSINOPHIL MAJOR BASIC PROTEIN; EOSINOPHILIA; EOSINOPHILS; EXTRACELLULAR MATRIX; HUMANS;

EID: 34748842265     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2007.07.025     Document Type: Editorial

References (12)

1. Talley N.J., Walker M.M., Aro P., et al. Non-ulcer dyspepsia and duodenal eosinophilia. An adult endoscopic population-based case-control study. Clin Gastroenterol Hepatol 5 (2007) 1175-1183
2. Kato M., Kephart G.M., Talley N.J., et al. Eosinophil infiltration and degranulation in normal human tissue. Anat Rec 252 (1998) 418-425
3. Debrosse C.W., Case J.W., Putnam P.E., et al. Quantity and distribution of eosinophils in the gastrointestinal tract of children. Pediatr Dev Pathol 9 (2006) 210-218
4. Rothenberg M.E. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113 (2004) 11-28
5. Rothenberg M.E., and Hogan S.P. The eosinophil. Annu Rev Immunol 24 (2006) 147-174
6. Jacoby D.B., Gleich G.J., and Fryer A.D. Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor. J Clin Invest 91 (1993) 1314-1318
7. Hogan S.P., Mishra A., Brandt E.B., et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol 2 (2001) 353-360
8. Aceves S.S., Newbury R.O., Dohil R., et al. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol 119 (2007) 206-212
9. Friesen C.A., Andre L., Garola R., et al. Activated duodenal mucosal eosinophils in children with dyspepsia: a pilot transmission electron microscopic study. J Pediatr Gastroenterol Nutr 35 (2002) 329-333
10. Friesen C.A., Kearns G.L., Andre L., et al. Clinical efficacy and pharmacokinetics of montelukast in dyspeptic children with duodenal eosinophilia. J Pediatr Gastroenterol Nutr 38 (2004) 343-351
11. Leiferman K.M., Ackerman S.J., Sampson H.A., et al. Dermal deposition of eosinophil-granule major basic protein in atopic dermatitis: comparison with onchocerciasis. N Engl J Med 313 (1985) 282-285
12. Santos J., Alonso C., Guilarte M., et al. Targeting mast cells in the treatment of functional gastrointestinal disorders. Curr Opin Pharmacol 6 (2006) 541-546