Effects of spermine on the relaxation response of rat detrusor smooth muscles

European Journal of Pharmacology

Volumn 573, Issue 1-3, 2007, Pages 196-200

  Myung, Soon Chul ^a   Oh, Seung Young ^a   Kim, Kyung Do ^a   Kim, Sae Chul ^a   Lee, Moo Yeol ^a  

^a Chung Ang University   (South Korea)

Author keywords

Detrusor; Polyamine; Relaxation; Spermine

Indexed keywords

ACETYLCHOLINE; BETHANECHOL; CALCIUM; CALCIUM CHANNEL; POLYAMINE; POTASSIUM; PUTRESCINE; SPERMIDINE; SPERMINE; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG EFFECT; DRUG POTENCY; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE TONE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BETHANECHOL; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE TONUS; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHLORIDE; PUTRESCINE; RATS; RATS, SPRAGUE-DAWLEY; SPERMIDINE; SPERMINE; TETRAETHYLAMMONIUM; URINARY BLADDER;

EID: 34648860633     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.024     Document Type: Article

References (19)

1. Brading A.F. Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J. Physiol. 570 (2006) 13-22
2. Chideckel E.W., Dedhia H.H., Fedan J.S., Teba L., and Jain A. Spermine decreases peripheral vascular resistance in the dog and relaxes the isolated aorta of the guinea pig. Cardiovasc. Res. 20 (1986) 931-934
3. 2+ current on the contractile performance of guinea pig detrusor smooth muscle. Neurourol. Urodyn. 22 (2003) 77-82
4. Fernandez A.I., Cantabrana B., Sanchez M., and Hidalgo A. Extracellular and intracellular effects of polyamines on smooth muscle contractions. Life Sci. 57 (1995) 855-861
5. 2+ channel activity in guinea-pig intestinal smooth muscle. Pflügers Arch. 438 (1999) 445-451
6. Herrera G.M., Heppner T.J., and Nelson M.T. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 (2000) R60-R68
7. Hudman D., Elliott R.A., and Norman R.I. Inhibition of the contractile response of the rat detrusor muscle by the beta(2)-adrenoceptor agonist clenbuterol. Eur. J. Pharmacol. 392 (2000) 79-85
8. Martin J.S., and Tansy M.F. Comparison of the inhibitory effects of spermine, papaverine and adrenaline upon isolated segments of the rat small intestine. Clin. Exp. Pharmacol. Physiol. 13 (1986) 87-90
9. Maruta K., Mizoguchi Y., and Osa T. Effects of polyamines on the mechanical and electrical activities of the isolated circular muscle of rat uterus. Jpn. J. Physiol. 35 (1985) 903-915
10. McCloskey K.D. Characterization of outward currents in interstitial cells from the guinea pig bladder. J. Urol. 173 (2005) 296-301
11. 2+ antagonistic properties. J. Pharm. Pharmacol. 52 (2000) 695-707
12. Myung S.C., Lee S.Y., Kang G.H., Keum E.M., Lee M.Y., and Kim S.C. Relaxation responses of isolated rabbit seminal vesicle to polyamines. Kor. J. Urol. 46 (2005) 169-173
13. Nilsson B.O., and Hellstrand P. Effects of polyamines on intracellular calcium and mechanical activity in smooth muscle of guinea-pig taenia coli. Acta Physiol. Scand. 148 (1993) 37-43
14. 2+ channel and phosphatase activities by polyamines in intestinal and vascular smooth muscle-implications for cellular growth and contractility. Acta Physiol. Scand. 176 (2002) 33-41
15. Pegg A.E. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J. 234 (1986) 249-262
16. Schipper R.G., Romijn J.C., Cuijpers V.M., and Verhofstad A.A. Polyamines and prostatic cancer. Biochem. Soc. Trans. 31 (2003) 375-380
17. Shyng S.L., Sha Q., Ferrigni T., Lopatin A.N., and Nichols C.G. Depletion of intracellular polyamines relieves inward rectification of potassium channels. Proc. Natl. Acad. Sci. 93 (1996) 12014-12019
18. Snetkov V.A., Gurney A.M., Ward J.P., and Osipenko O.N. Inward rectification of the large conductance potassium channel in smooth muscle cells from rabbit pulmonary artery. Exp. Physiol. 81 (1996) 743-753
19. Williams K. Interactions of polyamines with ion channels. Biochem. J. 325 (1997) 289-297