One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer;Ein molekül, zwei gesichter. Epithelialer verlust des zelladhäsionsmoleküls CEACAM1 aktiviert angiogenese beim harnblasen- und prostatakarzinom

Urologe - Ausgabe A

Volumn 46, Issue 9, 2007, Pages 1128-1134

  Tilki, D ^a   Oliveira Ferrer, L ^b   Kilic, N ^b   Friedrich, M G ^b   Stief, C G ^a   Ergun, S ^c  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Angiogenesis; Bladder cancer; CEACAM1; Prostate cancer; SiRNA

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; SMALL INTERFERING RNA;

ARTICLE; BLADDER CANCER; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EPITHELIUM; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; KNOCKOUT GENE; MALE; MOLECULE; NEOVASCULARIZATION (PATHOLOGY); PROSTATE CANCER; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR VASCULARIZATION; UPREGULATION;

ANTIGENS, CD; BLOTTING, WESTERN; CARCINOMA, TRANSITIONAL CELL; CELL ADHESION MOLECULES; CELL LINE, TUMOR; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICROSCOPY, ELECTRON; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PROSTATE; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 34648840266     PISSN: 03402592     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00120-007-1461-z     Document Type: Article

References (13)

1. Baluk P, Hashizume H, McDonald DM (2005) Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 15: 102-111
2. Carmeliet P (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med 6: 389-395
3. Ergun S, Kilik N, Ziegeler G et al. (2000) CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Mol Cell 5: 311-320
4. Ergun S, Tilki D, Oliveira-Ferrer L et al. (2005) Significance of vascular stabilization for tumor growth and metastasis. Cancer Lett 238: 180-187
5. Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364
6. Kalluri R (2003) Angiogenesis: Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 3: 422-433
7. Kilic N, Ergun S (2001) Methods to evaluate the formation and stabilization of blood vessels and their role in tumor growth and metastasis. In: Brooks SA, Schumacher U (eds) Methods in molecular medicine. Humana Press, Totowa/NJ, pp 125-148
8. Kilic N, Oliveira-Ferrer L, Wurmbach JH et al. (2005) Pro-angiogenic signaling by the endothelial presence of CEACAM1. J Biol Chem 280: 2361-2369
9. Kunath T, Ordonez-Garcia C, Turbide C, Beauchemin N (1995) Inhibition of colonic tumor cell growth by biliary glycoprotein. Oncogene 11: 2375-2382
10. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275
11. McDonald DM, Baluk P (2002) Significance of blood vessel leakiness in cancer. Cancer Res 62: 5381-5385
12. Oliveira-Ferrer L, Tilki D, Ziegeler G et al. (2004) Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer. Cancer Res 64: 8932-8938
13. Tilki D, Irmak S, Oliveira-Ferrer L et al. (2006) CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer. Oncogene 25: 4965-4974