KCNQ1/KCNE1 K+ channel and P2Y4 receptor are co-expressed from the time of birth in the apical membrane of rat strial marginal cells

Acta Oto-Laryngologica

Volumn 127, Issue SUPPL. 558, 2007, Pages 30-35

  Hur, Dong Gu ^a   Lee, Jun Ho ^b,d   Oh, Seung Ha ^b   Kim, Young Ho ^c   Lee, Jin Hee ^d   Shin, Dong Hoon ^d   Chang, Sun O ^b   Kim, Chong Sun ^b  

^a Gyeongsang National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University Boramae Hospital   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

Cochlea; KCNQ1 KCNE1 K+ channel; P2Y4; Rat; Strial marginal cell; Voltage sensitive vibrating probe

Indexed keywords

POTASSIUM CHANNEL KCNQ1; PURINE P2Y4 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CARTILAGINOUS TISSUE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT CIRCUIT CURRENT; STRIA VASCULARIS;

EID: 34648829839     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/03655230701624830     Document Type: Article

References (22)

1. + cycling and its regulation in the cochlea and the vestibular labyrinth. Audiol Neurootol 2002;7199-205.
2. Boeynaems JM, Communi D, Gonzalez NS, Robaye B. Overview of the P2 receptors. Semin Thromb Hemost 2005;31:139-49.
3. Housley GD, Jagger DJ, Greenwood D, Raybould NP, Salih SG, Jarlebark LE, et al. Purinergic regulation of sound transduction and auditory neurotransmission. Audiol Neurootol 2002;7:55-61.
4. Housley GD, Kanjhan R, Raybould NP, Greenwood D, Salih SG, Jarlebark L, et al. Expression of the P2X(2) receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission. J Neurosci 1999;19:8377-88.
5. + secretion by strial marginal cell epithelium. Cell Commun Signal 2005;3:13.
6. Yamasaki M, Komune S, Shimozono M, Matsuda K, Haruta A. Development of monovalent ions in the endolymph in mouse cochlea. ORL J Otorhinolaryngol Relat Spec 2000;62:241-6.
7. Hall JW. Development of the ear and hearing. J Perinatol 2000;20:S12-20.
8. + secretion and the transepithelial voltage across marginal cells of stria vascularis in vitro. Hear Res 1995;84:19-29.
9. Marcus DC. Vibrating probes: new technology for investigation of endolymph homeostasis. Keio J Med 1996;45:301-5.
10. Sage CL, Marcus DC. Immunolocalization of P2Y(4) and P2Y(2) purinergic receptors in strial marginal cells and vestibular dark cells. J Membr Biol 2002;185:103-15.
11. Wangemann P, Itza EM, Albrecht B, Wu T, Jabba SV, Maganti RJ, et al. Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model. BMC Med 2004;2:30.
12. Busch AE, Suessbrich H, Waldegger S, Sailer E, Greger R, Lang H, et al. Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B. Pflugers Arch 1996;432:1094-6.
13. sK channel in strial marginal cells: Voltage-dependence, ion-selectivity, inhibition by 293B and sensitivity to clofilium. Auditory Neurosci 1997;3:215-30.
14. Anniko M. Histochemical, microchemical (microprobe) and organ culture approaches to the study of auditory development. Acta Otolaryngol Suppl 1985;421:10-8.
15. von Kugelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 2006;110:415-32.
16. 2+ ions. Br J Pharmacol 2003;140:1177-86.
17. Bogdanov YD, Wildman SS, Clements MP, King BF, Burnstock G. Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Br J Pharmacol 1998;124:428-30.
18. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 1998;50:413-92.
19. Robaye B, Boeynaems JM, Communi D. Slow desensitization of the human P2Y6 receptor. Eur J Pharmacol 1997;329:231-6.
20. Munoz DJ, Kendrick IS, Rassam M, Thorne PR. Vesicular storage of adenosine triphosphate in the guinea-pig cochlear lateral wall and concentrations of ATP in the endolymph during sound exposure and hypoxia. Acta Otolaryngol 2001;121:10-5.
21. Housley GD. Physiological effects of extracellular nucleotides in the inner ear. Clin Exp Pharmacol Physiol 2000;27:575-80.
22. Marcotti W, Johnson SL, Holley MC, Kros CJ. Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells. J Physiol 2003;548:383-400.