Synthesis of 3-phenyl-4-phenylvinyl benzopyranones and the corresponding 2,2-dimethyl-benzopyrans with structural similarity to estradiol, as estrogen receptor ligands

Medicinal Chemistry

Volumn 3, Issue 5, 2007, Pages 446-454

  Gupta, Atul ^a,b,c   Raghunandan, Resmi ^a   Kumar, Atul ^a   Maulik, Prakash R ^a   Dwivedy, Anila ^a   Keshri, Govind ^a   Singh, Man Mohan ^a   Ray, Suprabhat ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

^c NONE   (India)

Author keywords

Antiestrogens; Estrogen agonists; Estrogen antagonists; Estrogen receptor (ER); LBD(ligand binding domain); RBA

Indexed keywords

2,2 DIMETHYL 7 METHOXY 3 PHENYL 4 [2 [4 (2 DIETHYLAMINOETHOXY)PHENYL]VINYL]BENZOPYRAN; 2,2 DIMETHYL 7 METHOXY 3 PHENYL 4 [2 [4 (2 DIMETHYLAMINO 1 METHYLETHOXY)PHENYL]VINYL]BENZOPYRAN; 2,2 DIMETHYL 7 METHOXY 3 PHENYL 4 [2 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]VINYL]BENZOPYRAN; 2,2 DIMETHYL 7 METHOXY 3 PHENYL 4 [2 [4 (2 PIPERIDIN 1 YL ETHOXY)PHENYL]VINYL]BENZOPYRAN; 2,2 DIMETHYL 7 METHOXY 3 PHENYL 4 [2 [4 (2 PYRROLIDIN 1 YL ETHOXY)PHENYL]VINYL]BENZOPYRAN; 2,2 DIMETHYLBENZOPYRAN DERIVATIVE; 4 [2 [4 (2 DIMETHYLAMINO 1 METHOXYETHOXY)PHENYL]VINYL] 7 METHOXY 3 PHENYLCHROMEN 2 ONE; 7 METHOXY 3 PHENYL 4 [2 [4 (2 DIETHYLAMINOETHOXY)PHENYL]VINYL]BENZOPYRAN 2 ONE; 7 METHOXY 3 PHENYL 4 [2 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]VINYL]CHROMEN 2 ONE; 7 METHOXY 3 PHENYL 4 [2 [4 (2 PIPERIDIN 1 YL ETHOXY)PHENYL]VINYL]BENZOPYRAN 2 ONE; 7 METHOXY 3 PHENYL 4 [2 [4 (2 PYRROLIDIN 1 YL ETHOXY)PHENYL]VINYL]BENZOPYRAN 2 ONE; 7 METHOXY 3 PHENYL 4 PHENYLVINYLBENZOPYRAN 2 ONE DERIVATIVE; ALKYL GROUP; AMINO ACID; BENZOPYRAN DERIVATIVE; CENTCHROMAN; ESTRADIOL; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; HORMONE RECEPTOR AFFECTING AGENT; HYDROXYL GROUP; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HORMONAL REGULATION; HORMONE INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS; X RAY ANALYSIS;

BENZOPYRANS; CRYSTALLOGRAPHY, X-RAY; ESTRADIOL; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, ESTROGEN; SPECTROPHOTOMETRY, INFRARED;

EID: 34648827181     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607781745483     Document Type: Article

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