Characterization of a murine model of fetal programming of atherosclerosis

American Journal of Obstetrics and Gynecology

Volumn 197, Issue 4, 2007, Pages 416.e1-416.e5

  Goharkhay, Nima ^a   Sbrana, Elena ^a   Gamble, Phyllis K ^a   Tamayo, Esther H ^a   Betancourt, Ancizar ^a   Villarreal, Karina ^a   Hankins, Gary D V ^a   Saade, George R ^a   Longo, Monica ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

atherosclerosis; fetal development; fetal programming; hypercholesterolemia; mouse model

Indexed keywords

APOLIPOPROTEIN E;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; APOE GENE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS BREEDING; DISEASE MODEL; DISEASE SEVERITY; FEMALE; FETUS DEVELOPMENT; HISTOPATHOLOGY; INCIDENCE; KIDNEY PARENCHYMA; KNOCKOUT GENE; LIVER PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

EID: 34648822991     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2007.08.002     Document Type: Article

References (11)

1. Barker D.J., and Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1 (1986) 1077-1081
2. Barker D.J. In utero programming of cardiovascular disease. Theriogenology 53 (2000) 555-574
3. Napoli C., D'Armiento F.P., Mancini F.P., et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 100 (1997) 2680-2690
4. Napoli C., Glass C.K., Witztum J.L., Deutsch R., D'Armiento F.P., and Palinski W. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet 354 (1999) 1234-1241
5. Palinski W., D'Armiento F.P., Witztum J.L., et al. Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits. Circ Res 89 (2001) 991-996
6. Reardon C.A., and Getz G.S. Mouse models of atherosclerosis. Curr Opin Lipidol 12 (2001) 167-173
7. Jawien J., Nastalek P., and Korbut R. Mouse models of experimental atherosclerosis. J Physiol Pharmacol 55 (2004) 503-517
8. Wouters K., Shiri-Sverdlov R., van Gorp P.J., van Bilsen M., and Hofker M.H. Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice. Clin Chem Lab Med 43 (2005) 470-479
9. Nunnari J.J., Zand T., Joris I., and Majno G. Quantitation of oil red O staining of the aorta in hypercholesterolemic rats. Exp Mol Pathol 51 (1989) 1-8
10. Yoshida S., and Wada Y. Transfer of maternal cholesterol to embryo and fetus in pregnant mice. J Lipid Res 46 (2005) 2168-2174
11. Madsen C., Dagnaes-Hansen F., Moller J., and Falk E. Hypercholesterolemia in pregnant mice does not affect atherosclerosis in adult offspring. Atherosclerosis 168 (2003) 221-228