Modelling the relationship between antiretroviral treatment and HIV prevention: Limitations of the Spectrum AIDS Impact Model in changing policy environment

African Journal of AIDS Research

Volumn 6, Issue 2, 2007, Pages 129-137

  Nattrass, Nicoli ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Demographic models; HAART; Health impact; Interventions; Mathematical models; Policy development; Sexual risk behaviour; South Africa

Indexed keywords

ANTIRETROVIRUS AGENT; NEVIRAPINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CASE STUDY; CONTROLLED STUDY; EPIDEMIC; HIGH RISK BEHAVIOR; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; POLICY; PREDICTION; PREVALENCE; SEXUAL BEHAVIOR; SOUTH AFRICA;

EID: 34648820316     PISSN: 16085906     EISSN: None     Source Type: Journal    
DOI: 10.2989/16085900709490407     Document Type: Article

References (41)

1. Badri, M., Maartens, G., Mandalia, S., Bekker, L., Penrod, J., Piatt, R., Wood, R. & Beck, E. (2006) Cost-effectiveness of highly active antiretroviral therapy in South Africa. PLOS Medicine 3(1), pp. 1-9.
2. Binswanger, H. (2003) Willingness to pay for AIDS treatment: myths and realities. The Lancet 362 (9390), pp. 1152-1153.
3. Blower, S., Gershengorn, H. & Grant, R. (2000) A tale of two futures: HIV and antiretroviral therapy in San Francisco. Science 287(5453), pp. 650-654.
4. Boily, M., Godin, G, Hogben, M., Sherr, L. & Bastos, F. (2005) The impact of the transmission dynamics of the HIV/AIDS epidemic on sexual behaviour: a new hypothesis to explain recent increases in risk-taking behaviour among men who have sex with men. Medical Hypotheses 65, pp. 215-226.
5. Burman, W., Grund, B., Neuhaus, J., Douglas, J., Friedland, G., Rietmeijer, C. & the SMART Study Group (2007) The effect of episodic ART on HIV transmission risk: a sub-study of the SMART study (Abstract 979). 14th Conference on Retroviruses and Opportunist Infections, Los Angeles, 25-28 February 2007.
6. Cohen, M. & Hosseinipour, M. (2005) HIV treatment meets prevention: antiretroviral therapy as prophylaxis. In: Mayer, K. & Pizer, H. (eds.) The AIDS Pandemic: Impact on Science and Society. London, Elsevier Academic Press.
7. Cox, J., Beauchemin, J. & Allard, R. (2004) HIV status of sexual partners is more important than antiretroviral treatment-related perceptions for risk-taking by HIV-positive MSM in Montreal, Canada. Sexually Transmitted Infections 80(6), pp. 518-523.
8. Creese, A., Floyd, K., Alban, A. & Guinness, L. (2002) Cost-effectiveness of HIV/AIDS interventions in Africa: a systematic review of the evidence. The Lancet 359 (9318), pp. 1635-1642.
9. Crepaz, N., Hart, T. & Marks, G. (2006) Highly active antiretroviral therapy and sexual risk behaviour. Journal of the American Medical Association 292(2), pp. 224-236.
10. Dorrington, R., Bradshaw, D., Johnson, L. & Daniel, T. (2006) The Demographic Impact of HIV/AIDS in South Africa: National and Provincial Indicators for 2006. Cape Town, Joint publication of the Centre for Actuarial Research, the Burden of Disease Research Unit and the Actuarial Society of South Africa (ASSA).
11. Elford, J., Bolding, G., & Sherr, L. (2002) High-risk sexual behaviour increases among London gay men between 1998 and 2001: What is the role of HIV optimism? AIDS 16(11), pp. 1537-1544.
12. England, R. (2006) Are we spending too much on HIV? British Medical Journal 334(7589), p. 344.
13. Farmer, P., Leandre, F., Mukherjee, J., Sidonise Claude, M., Nevil, P., Smith-Fawzi, M., Koenig, S., Castro, A., Becerra, M., Sachs, J., Attaran, M. & Yong Kim, J. (2001) Community-based approaches to HIV treatment in resource-poor settings. The Lancet 358 (9279), pp. 404-409.
14. Feachem, R. & Sabot, O. (2006) An examination of the Global Fund at 5 years. The Lancet 368 (9534), pp. 537-540.
15. Glass, T., Young, J., Vernazza, P., Rickenbach, M., Weber, R., Cavassini, M., Hirschel, B., Battegay, M., Bucher, H. & the Swiss HIV Cohort Study (2004) Is unsafe sexual behaviour increasing among HIV-infected individuals? AIDS 18(2), pp. 1707-1714.
16. Graham, S., Holte, S., Peshu, N., Richardson, B., Panteleef, D., Jaoko, W., Ndinya-Achola, J., Mandaliva, J., Overbaugh, J. & McClelland, R. (2007) Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal shedding of HIV-1. AIDS 21, pp. 501-507.
17. Halkitis, P. & Parsons, J. (2003) Intentional unsafe sex (barebacking) among HIV-positive gay men who seek sexual partners on the Internet. AIDS Care 15(3), pp. 367-378.
18. Jones, S. & Varga, C. (2001) Bloodwise? Knowledge and attitudes pertaining to HIV and blood donation in Durban. Society in Transition 32(1), pp. 24-37.
19. Leclerc-Madlala, S. (1997) Infect one, infect all: Zulu youth response to the AIDS epidemic in South Africa. Medical Anthropology 17, pp. 363-380.
20. Lewis, S. (2005) Race Against Time. Toronto, House of Anansi Press.
21. Marseille, E., Hofmann, P. & Kahn, K. (2002) HIV prevention before HAART in sub-Saharan Africa. The Lancet 359 (9320), pp. 1851-1856.
22. McCormick, A., Walensky, R., Lipsitch, M., Losina, E., Hsu, H., Weinstein, M., Paltiel, A., Freedberg, K. & Seage, G (2007) The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with men. Clinical Infectious Diseases 44, pp. 1115-1122.
23. Moatti, J., Doye, I., Hammer, S., Hale, P. & Kazatchkine, M. (2003) Antiretroviral treatment for HIV infection in developing countries: an attainable new paradigm. Nature Medicine 9(12), pp. 1449-1452.
24. Moatti, J., Prudhomme, J., Traore, D., Juillet-Amari, A. Akribi, H., Msellati, P. & the Cote d'Ivoire Drug Access Initiative Socio-Behavioural Evaluation Group (2003) Access to antiretroviral treatment and sexual behaviours of HIV-infected patients aware of their serostatus in Cote D'Ivoire. AIDS 17 (Supplement 3), pp. s69-s77.
25. Montaner, J., Hogg, R., Wood, E., Kerr, T., Tyndall, M., Levey, A. & Harrigan, R. (2006) The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. The Lancet 368 (9534), pp. 531-536.
26. Morin, S., Vernon, K., Harcourt, J., Steward, W., Volk, J., Riess, T., Neilands, T., McLaughlin, M. & Coates, T. (2003) Why HIV infections have increased among men who have sex with men and what to do about it: findings from California focus groups. AIDS and Behaviour 7(4), pp. 353-362.
27. Nattrass, N. & Geffen, N. (2005) The impact of reduced drug prices on the cost-effectiveness of HAART in South Africa. African Journal of AIDS Research (AJAR) 4(1), pp. 65-67.
28. Piot, P. (2006) AIDS: from crisis management to sustained strategic response. The Lancet 368 (9534), pp. 526-530.
29. Porco, T., Martin, J., Page-Shafer, K., Cheng, A., Charlebois, E., Grant, R. & Osmond, D. (2004) Decline in HIV infectivity following the introduction of highly active antiretroviral therapy. AIDS 18, pp. 81-88.
30. Sachs, S.E. & Sachs, J. (2004) Too poor to stay alive. In: Kauffman, K. & Lindauer, D. (eds.) AIDS and South Africa: The Social Expression of a Pandemic. New York, Palgrave Macmillan.
31. Sarna, A., Luchters, S., Kaai, S., Munyao, P., Geibel, S., Shikely, K., Mandaliya, K., Hawken, M., Van Dam, J. & Temmerman, M. (2005) Does being treated with HAART affect the sexual risk behaviour of people living with HIV/AIDS? Insights from Mombasa, Kenya. Nairobi, Kenya, Population Council, Horizons Research Update.
32. Schwartlander, B., Grubb, I. & Perriens, J. (2006) The 10-year struggle to provide antiretroviral treatment to people with HIV in the developing world. The Lancet 368 (9534), pp. 541-546.
33. Sepkowitz, K. (2000) AIDS - the first 20 years. New England Journal of Medicine 344, pp. 1764-1772.
34. Stover, J. (2004) Projecting the demographic consequences of adult HIV prevalence trends: the Spectrum Projection Package. Sexually Transmitted Infections 80 (Supplement 1), pp. i14-i18.
35. Stover, J. (2005) AIDS Impact Model (AIM) Version 4. A Computer Program for HIV/AIDS Projections and Examining the Social and Economic Impacts of AIDS. Glastonbury, Connecticut, Futures Group.
36. Stover, J., Walker, N., Grassly, N. & Marston, M. (2006) Projecting the Demographic impact of AIDS and the number of people in need of treatment: updates to the Spectrum Projection Package. Sexually Transmitted Infections 82 (Supplement 3), pp. iii45-iii50.
37. UNAIDS (2005) Intensifying HIV Prevention: UNAIDS Policy Position Paper. Geneva.
38. UNAIDS (2006) 2006 Report on the Global AIDS Epidemic. UNAIDS, Geneva.
39. Van der Snoek, E., De Wit, J., Mulder, P. & Van der Meijden, W. (2005) Incidence of sexually transmitted diseases and HIV infection related to perceived HIV/AIDS threat since highly active antiretroviral therapy availability in men who have sex with men. Journal of the American Sexually Transmitted Disease Association 32(3), pp. 170-175.
40. WHO (2005) Progress on Global Access to HIV Antiretroviral Therapy: An Update on '3 by 5.' Geneva.
41. Wolf, K., Young, J., Rickenbach, M., Vernazza, P., Flepp, M., Furrer, H., Bernasconi, E., Bernard, H., Amaliio, T., Rainder, W., Bucher, H. & the Swiss HIV Cohort Study (2003) Prevalence of unsafe sexual behaviour among HIV-infected individuals: the Swiss HIV Cohort Study. Journal of AIDS 33, pp. 494-499.