Determination of dimethylarginine dimethylaminohydrolase activity in the kidney

Kidney International

Volumn 72, Issue 7, 2007, Pages 886-889

  Tain, Y L ^a,b   Baylis, C ^a,c  

^a UNIVERSITY OF FLORIDA   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Asymmetric dimethylarginine; Dimethylarginine dimethylaminohydrolase; L citrulline; Nitric oxide; Urea

Indexed keywords

ARGINASE; CITRULLINE; DIMETHYLARGININASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATE BUFFERED SALINE; PROTEINASE INHIBITOR; SULFOSALICYLIC ACID; SUPEROXIDE; UREA; UREASE;

ANIMAL TISSUE; ARTICLE; COLORIMETRY; ENZYME ASSAY; IN VITRO SELECTION; KIDNEY HOMOGENATE; LABORATORY DIAGNOSIS; MALE; NONHUMAN; PRESCOTT JONES COLORIMETRIC ASSAY; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

AMIDOHYDROLASES; ANIMALS; ARGININE; CITRULLINE; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY; UREA;

EID: 34648820108     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002446     Document Type: Article

References (19)

1. Leiper JM, Santa Maria J, Chubb A et al. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine diminishes. Biochem J 1999; 343: 209-214.
2. MacAllister RJ, Parry H, Kimoto M et al. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol 1996; 119: 1533-1540.
3. Ito A, Tsao PS, Adimoolam S et al. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999; 99: 3092-3095.
4. Prescott LM, Jones ME. Modified methods for the determination of carbamyl aspartate. Anal Biochem 1969; 32: 408-419.
5. Boyde TR, Rahmatullah M. Optimization of conditions for the colorimetric determination of L-citrulline, using diacetyl monoxime. Anal Biochem 1980; 107: 424-431.
6. Knipp M, Vasak M. A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed L-citrulline. Anal Biochem 2000; 286: 257-264.
7. Gornall AG, Hunter A. A colorimetric method for the determination of L-citrulline. Biochem J 1941; 35: 650-658.
8. Safirstein R, Miller P, Kahn T. Cortical and papillary absorptive defects in gentamicin nephrotoxicity. Kidney Int 1983; 24: 526-533.
9. Kulhanek V, Maderova V, Sindelarova K, Vojtiskova V. Modified determination of ornithine-carbamyl-transferase activity in biological material. Clin Chim Acta 1963; 8: 579-585.
10. Ogawa T, Kimoto M, Sasaoka K. Purification and properties of a new enzyme NG NG-dimethylarginine dimethylaminohydrolase, from rat kidney. J Biol Chem 1989; 264: 10205-10209.
11. Stuhlinger MC, Tsao PS, Her JH et al. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001; 104: 2569-2575.
12. Yin QF, Xiong Y. Pravastatin restores DDAH activity and endothelium-dependent relaxation of rat aorta after exposure to glycated protein. J Cardiovasc Pharmacol 2005; 45: 525-532.
13. Chen Y, Li Y, Zhang P et al. Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts. Am J Physiol Heart Circ Physiol 2005; 289: H2212-H2219.
14. Edmonds MS, Lowry KR, Baker DH. Urea cycle metabolism: effects of supplemental ornithine or L-citrulline on performance, tissue amino acid concentrations and enzymatic activity in young pigs fed arginine-deficient diets. J Anim Sci 1987; 65: 706-716.
15. Ratner S, Petrack B. Biosynthesis of urea. IV. Further studies on condensation in arginine synthesis from citrulline. J Biol Chem 1953; 200: 161-174.
16. Curis E, Nicolis I, Moinard C et al. Almost all about L-citrulline in mammals. Amino Acids 2005; 29: 177-205.
17. Knipp M. How to control NO production in cells: N(omega), N(omega)-dimethyl-L-arginine dimethylaminohydrolase as a novel drug target. Chembiochem 2006; 7: 879-889.
18. Leiper J, Murray-Rust J, McDonald N, Vallance P. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci USA 2002; 99: 13527-13532.
19. Tain YL, Freshour G, Dikalova A et al. Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. Am J Physiol Renal Physiol 2007; 292: F1404-F1410.