Innervation of tissue-engineered corneal implants in a porcine model: A 1-year in vivo confocal microscopy study

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 8, 2007, Pages 3537-3544

  Lagali, Neil S ^a   Griffith, May ^a,b   Shinozaki, Naoshi ^c   Fagerholm, Per ^d   Munger, Rejean ^a  

^a UNIVERSITY OF OTTAWA EYE INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c BUILDING RESEARCH INSTITUTE   (Japan)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CROSS LINKING REAGENT;

ANIMAL TISSUE; ARTICLE; BIODEGRADABLE IMPLANT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA STROMA; KERATOPROSTHESIS; NERVE GROWTH; NERVE REGENERATION; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; REINNERVATION; TISSUE ENGINEERING; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; ANIMAL MODEL; CORNEA; INNERVATION; MALE; MINIPIG; NERVE FIBER; PROSTHESES AND ORTHOSES; SWINE; ULTRASTRUCTURE;

ANIMALS; COLLAGEN; CORNEA; CROSS-LINKING REAGENTS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, ANIMAL; NERVE FIBERS; NERVE REGENERATION; PROSTHESES AND IMPLANTS; SWINE; SWINE, MINIATURE; TISSUE ENGINEERING;

EID: 34648817066     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1483     Document Type: Article

References (26)

1. Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79:214-221.
2. Li F, Carlsson DJ, Lohmann CP, et al. Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation. Proc Natl Acad Sci USA. 2003;100:15346-15351.
3. Liu Y, Gan L, Carlsson DJ, et al. A simple, cross-linked collagen tissue substitute for corneal implantation. Invest Ophthalmol Vis Sci. 2006;47:1869-1875.
4. Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. 2nd ed. St. Louis, MO: Elsevier Mosby; 2005;21.
5. Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea. 2001;20:374-384.
6. Grupcheva CN, Wong T, Riley AF, McGhee CNJ. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Exp Ophthalmol. 2002;30:187-190.
7. Patel DV, McGhee CNJ. Mapping of the normal human corneal sub-basal nerve plexus by in vivo laser scanning confocal microscopy. Invest Ophthalmol Vis Sci. 2005;46:4485-4488.
8. Tuominen ISJ, Konttinen YT, Vesaluoma MH, Moilanen JAO, Helintö M, Tervo TMT. Corneal innervation and morphology in primary Sjögren's syndrome. Invest Ophthalmol Vis Sci. 2003;44:2545-2549.
9. Mannion LS, Tromans C, O'Donnell C. An evaluation of corneal nerve morphology and function in moderate keratoconus. Cont Lens Ant Eye. 2005;28:185-192.
10. Hossain P, Sachdev A, Malik RA. Early detection of diabetic peripheral neuropathy with corneal confocal microscopy. Lancet. 2005;366:1340-1343.
11. Linna TU, Minna HV, Pérez-Santonja JJ, Petroll WM, Alió JL, Tervo TMT. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Invest Ophthalmol Vis Sci. 2000;41:393-397.
12. Erie JC, Patel SV, Bourne WM. Aberrant corneal nerve regeneration after PRK. Cornea. 2003;22:684-686.
13. Calvillo MP, McLaren JW, Hodge DO, Bourne WM. Corneal reinnervation after LASIK: prospective 3-year longitudinal study. Invest Ophthalmol Vis Sci. 2004;45:3991-3996.
14. Bragheeth MA, Dua HS. Corneal sensation after myopic and hyperopic LASIK: clinical and confocal microscopic study. Br J Ophthalmol. 2005;89:580-585.
15. Tervo T, Vannas A, Tervo K, Holden BA. Histochemical evidence of limited reinnervation of human corneal grafts. Acta Ophthalmol. 1985;63:207-214.
16. Rao GN, John T, Ishida N, Aquavella JV. Recovery of corneal sensitivity in grafts following penetrating keratoplasty. Ophthalmology. 1985;92:1408-1411.
17. Bohm A, Kohlhaas M, Kliefoth U, et al. Corneal reinnervation after lamellar keratoplasty in comparison with epikeratophakia and photorefractive keratectomy. Ophthalmologe. 1994;91:632-637.
18. Richter A, Slowik C, Somodi S, Vick HP, Guthoff R. Corneal reinnervation following penetrating keratoplasty: correlation of esthesiometry and confocal microscopy. Ger J Ophthalmol. 1996;5:513-517.
19. Erskine L, McCaig CD. Integrated interactions between chondroitin sulphate proteoglycans and weak dc electric fields regulate nerve growth cone guidance in vitro. J Cell Sci. 1997;110:1957-1965.
20. Abramoff MD, Magelhaes PJ, Ram SJ. Image processing with Image. J Biophoton Int. 2004;11:36-42.
21. Meijering E, Jacob M, Sarria J-CF, Steiner P, Hirling H, Unser M. Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry. 2004;58:167-176.
22. McLaren JW, Nau CB, Kitzmann AS, Bourne WM. Keratocyte density: comparison of two confocal microscopes. Eye Cont Lens. 2005;31:28-33.
23. Møller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy: a 1-year confocal microscopic study. Ophthalmology. 2000;107:1235-1245.
24. Tervo T, Moilanen J. In vivo confocal microscopy for evaluation of wound healing following corneal refractive surgery. Prog Retin Eye Res. 2003;22:339-358.
25. Bourne WM. Cellular changes in transplanted human corneas. Cornea. 2001;20:560-569.
26. Erie JC, McLaren JW, Hodge DO, Bourne WM. Recovery of corneal subbasal nerve density after PRK and LASIK. Am J Ophthalmol. 2005;140:1059-1064.