The Role of Contrast-Enhanced Ultrasound for Focal Liver Lesion Detection: An Overview

Ultrasound in Medicine and Biology

Volumn 33, Issue 10, 2007, Pages 1515-1526

  Konopke, R ^a   Bunk, A ^a   Kersting, S ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Contrast enhanced intraoperative ultrasound; Contrast enhanced ultrasound; Focal liver lesions

Indexed keywords

CHEMOTHERAPY; COMPUTERIZED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING; PATIENT MONITORING; TUMORS; ULTRASONOGRAPHY;

CONTRAST-ENHANCED INTRAOPERATIVE ULTRASOUNDS; CONTRAST-ENHANCED ULTRASOUNDS; FOCAL LIVER LESIONS; LIVER TUMORS;

ULTRASONIC DEVICES;

B SCAN; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; HUMAN; INTERMETHOD COMPARISON; INTRAOPERATIVE PERIOD; LIVER ADENOMA; LIVER CANCER; LIVER CELL CARCINOMA; LIVER HEMANGIOMA; LIVER METASTASIS; NODULAR HYPERPLASIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; ULTRASOUND;

CARCINOMA, HEPATOCELLULAR; COLORECTAL NEOPLASMS; CONTRAST MEDIA; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LIVER DISEASES; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 34548860078     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2007.04.009     Document Type: Review

References (86)

1. Adam R. Chemotherapy and surgery. New perspectives on the treatment of unresectable liver metastases. Ann Oncol 14 Suppl 2 (2003) ii13-ii16
2. Adson M.A. Resection of liver metastases-When is it worthwhile?. World J Surg 11 4 (1987) 511-520
3. Albrecht T., Blomley M., Bolondi L., Claudon M., Correas J.M., Cosgrove D., Greiner L., Jager K., Jong N.D., Leen E., Lencioni R., Lindsell D., Martegani A., Solbiati L., Thorelius L., Tranquart F., Weskott H.P., and Whittingham T. EFSUMB Study Group guidelines for the use of contrast agents in ultrasound. Ultraschall Med 25 (2004) 249-256
4. Albrecht T., Thorelius L., Solbiati L., Cova L., and Frauscher F. Contrast-enhanced ultrasound in clinical practice (2005), Springer-Verlag, Milan, Italy
5. Bartolotta T.V., Midiri M., Quaia E., Bertolotto M., Galia M., Cademartiri F., Lagalla R., and Cardinale A.E. Benign focal liver lesions: spectrum of findings on SonoVue-enhanced pulse-inversion ultrasonography. Eur Radiol 15 (2005) 1643-1649
6. Bartolozzi C., Lencioni R., Paolicchi A., Moretti M., Armillotta N., and Pinto F. Differentiation of hepatocellular adenoma and focal nodular hyperplasia of the liver: Comparison of power Doppler imaging and conventional color Doppler sonography. Eur Radiol 7 (1997) 1410-1415
7. Basilico R., Blomley M.J., Harvey C.J., Filippone A., Heckemann R.A., Eckersley R.J., and Cosgrove D.O. Which continuous US scanning mode is optimal for the detection of vascularity in liver lesions when enhanced with a second generation contrast agent?. Eur J Radiol 41 (2002) 184-191
8. Bernatik T., Strobel D., Hahn E.G., and Becker D. Detection of liver metastases: Comparison of contrast-enhanced wide-band harmonic imaging with conventional ultrasonography. J Ultrasound Med 20 (2001) 509-515
9. Blakeborough A., Ward J., Wilson D., Griffiths M., Kajiya Y., Guthrie J.A., and Robinson P.J. Hepatic lesion detection at MR imaging: A comparative study with four sequences. Radiology 203 (1997) 759-765
10. Bleuzen A., and Tranquart F. Incidental liver lesions: Diagnostic value of cadence contrast pulse sequencing (CPS) and SonoVue. Eur Radiol 14 Suppl 8 (2004) P53-P62
11. Bleuzen A., Huang C., Olar M., Tchuenbou J., and Tranquart F. Diagnostic accuracy of contrast-enhanced ultrasound in focal lesions of the liver using cadence contrast pulse sequencing. Ultraschall Med 27 (2006) 40-48
12. Bluemke D.A., Paulson E.K., Choti M.A., DeSena S., and Clavien P.A. Detection of hepatic lesions in candidates for surgery: Comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT. AJR Am J Roentgenol 75 (2000) 1653-1658
13. Bruix J., Sherman M., Llovet J.M., Beaugrand M., Lencioni R., Burroughs A.K., Christensen E., Pagliaro L., Colombo M., Rodes J., and EASL Panel of Experts on HCC. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona 2000 EASL Conference. European Association for the Study of the Liver. J Hepatol 35 (2001) 421-430
14. Bruix J., and Sherman M. Management of hepatocellular carcinoma. Hepatology 42 (2005) 1208-1236
15. Catalano O., Lobianco R., Cusati B., and Siani A. Hepatocellular carcinoma: spectrum of contrast-enhanced gray-scale harmonic sonography findings. Abdom Imaging 29 (2004) 341-347
16. Cervone A., Sardi A., and Conaway G.L. Intraoperative ultrasound (IOUS) is essential in the management of metastatic colorectal liver lesions. Am Surg 66 (2000) 611-615
17. Choi B. The current status of imaging diagnosis of hepatocellular carcinoma. Liver Transpl 10 2 Suppl 1 (2004) S20-S25
18. Conlon R., Jacobs M., Dasgupta D., and Lodge J.P. The value of intraoperative ultrasound during hepatic resection compared with improved preoperative magnetic resonance imaging. Eur Ultrasound 16 (2003) 211-216
19. Descottes B., Glineur D., Lachachi F., Valleix D., Paineau J., Hamy A., Morino M., Bismuth H., Castaing D., Savier E., Honore P., Detry O., Legrand M., Azagra J.S., Goergen M., Ceuterick M., Marescaux J., Mutter D., de Hemptinne B., Troisi R., Weerts J., Dallemagne B., Jehaes C., Gelin M., Donckier V., Aerts R., Topal B., Bertrand C., Mansvelt B., Van Krunckelsven L., Herman D., Kint M., Totte E., Schockmel R., and Gigot J.F. Laparoscopic liver resection of benign liver tumors. Surg Endosc 17 (2003) 23-30
20. Di Stasi M., Caturelli E., De Sio I., Salmi A., Buscarini E., and Buscarini L. Natural history of focal nodular hyperplasia of the liver: An ultrasound study. J Clin Ultrasound 24 (1996) 345-350
21. Ding H., Wang W.P., Huang B.J., Wei R.X., He N.A., Qi Q., and Li C.L. Imaging of focal liver lesions-low- mechanical-index real-time ultrasonography with SonoVue. J Ultrasound Med 24 (2005) 285-297
22. Doci R., Gennari L., Bignami P., Montalto F., Morabito A., and Bozzetti F. One hundred patients with hepatic metastases from colorectal cancer treated by resection. Analysis of prognostic determinants. Br J Surg 78 7 (1991) 797-801
23. Eberhardt S.C., Choi P.H., Bach A.M., Funt S.A., Felderman H.E., and Hann L.E. Utility of sonography for small hepatic lesions found on computed tomography in patients with cancer. J Ultrasound Med 22 (2003) 335-343
24. EFSUMB Study Group. The EFSUMB guidelines for the use of contrast agents in ultrasound. Ultraschall Med 25 (2004) 249-256
25. El-Serab H.B., and Mason A.C. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340 (1999) 745-750
26. Feldmann M. Haemangioma of the liver. Am J Clin Pathol 29 (1958) 160-162
27. Fevery J., Baert A.L., Marchal G.M., Broeckaert L., De Groote J., and Vantrappen G. The value of computed tomography, ultrasonography, and peritoneoscopy with biopsy in the detection of liver metastases secondary to gastroenterological tumors. Acta Gastroenterol Belg 48 (1985) 105-110
28. Fong Y., Fortner J., Sun R.L., Brennan M.F., and Blumgart L.H. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: Analysis of 1001 consecutive cases. Ann Surg 230 (1999) 309-318
29. Foster J.H., and Berman M.M. The malignant transformation of liver cell adenomas. Arch Surg 129 (1994) 712-717
30. Gandolfi L., Leo P., and Solmi L. Natural history of hepatic haemangioma: Clinical and ultrasound study. Gut 38 (1991) 677-680
31. Giorgio A., Ferraioli G., Tarantino L., de Stefano G., Scala V., Scarano F., Coppola C., and Del Viscovo L. Contrast-enhanced sonographic appearance of hepatocellular carcinoma in patients with cirrhosis: Comparison with contrast-enhanced helical CT appearance. Am J Roentgenol 183 (2004) 1319-1326
32. Hölscher A.H., and Stadler J. Intraoperative Sonographie zum Nachweis occulter Lebermetastasen beim kolorektalen Carzinom. Langenbecks Arch Chir 374 (1989) 363-369
33. Hussain S.M., Terkivatan T., Zondervan P.E., Lanjouw E., de Rave S., Ijzermans J.N., and de Man R.A. Focal nodular hyperplasia: Findings at state-of-the-art MR imaging, US, CT, and pathologic analysis. Radiographics 24 (2004) 3-17 discussion 18-19
34. Itai Y., Ohtomo K., Furui S., Yamauchi T., Minami M., and Yashiro N. Non-invasive diagnosis of small cavernous haemangioma of the liver. Advantage of MRI. AJR Am J Roentgenol 145 (1985) 1195-1199
35. Jang H.J., Lim H.K., Lee W.J., Kim S.H., Kim K.A., and Kim E.Y. Ultrasonographic evaluation of focal hepatic lesions: Comparison of pulse inversion harmonic, tissue harmonic and conventional imaging techniques. J Ultrasound Med 19 (2000) 293-299
36. Karhunen P.J. Benign hepatic tumours and tumour-like conditions in men. J Clin Pathol 39 (1986) 183-188
37. Kehagias D., Moulopoulos L., Antoniou A., Hatziioannou A., Smyrniotis V., Trakadas S., Lahanis S., and Vlahos L. Focal nodular hyperplasia: Imaging findings. Eur Radiol 11 (2001) 202-212
38. Kim S.H., Lim H.K., Lee W.J., Cho J.M., and Jang H.J. Needle-tract implantation in hepatocellular carcinoma: Frequency and CT findings after biopsy with a 19.5-gauge automated biopsy gun. Abdom Imaging 25 (2000) 246-250
39. Kim T.K., Kim A.Y., and Choi B.I. Hepatocellular carcinoma: harmonic ultrasound and contrast agent. Abdom Imaging 27 (2002) 129-138
40. Kim Y.H., Saini S., Blake M.A., Harisinghani M., Chiou Y.Y., Lee W.J., Yu J.S., and Hahn P.F. Distinguishing hepatic metastases from haemangiomas: Qualitative and quantitative diagnostic performance through dual echo respiratory-triggered fast spin echo magnetic resonance imaging. J Comput Assist Tomogr 29 (2005) 571-579
41. Konopke R., and Saeger H.D. Lebermetastasen: Diagnostik und Therapie. Chirurgie 74 (2003) 866-886
42. Konopke R., Kersting S., Saeger H.D., and Bunk A. Detection of liver lesions by contrast-enhanced ultrasound-Comparison to intraoperative findings. Ultraschall Med 26 (2005) 107-113
43. Leen E. The role of contrast-enhanced ultrasound in the characterization of focal liver lesions. Eur Radiol 11 Suppl 3 (2001) E27-E34
44. Leen E., Angerson W.J., Yarmenitis S., Bongartz G., Blomley M., Del Maschio A., Summaria V., Maresca G., Pezzoli C., and Llull J.B. Multi-centre clinical study evaluating the efficacy of SonoVue (BR1), a new ultrasound contrast agent in Doppler investigation of focal hepatic lesions. J Radiol 42 (2002) 200-206
45. Leen E., Becker D., Bolondi L., Steinbach R., Weskott H., Stacul F., and Ricci P. Prospective, open-label, multi-centre study evaluating the accuracy of unenhanced versus SonoVue enhanced ultrasonography in the characterization of focal liver lesions. Ultrasound Med Biol 29 (2003) S1-S12
46. Leen E., Ceccotti P., Moug S.J., Glen P., MacQuarrie J., Angerson W.J., Albrecht T., Hohmann J., Oldenburg A., Ritz J.P., and Horgan P.G. Potential value of contrast-enhanced intraoperative ultrasonography during partial hepatectomy for metastases: An essential investigation before resection?. Ann Surg 243 (2006) 236-240
47. Leese T., Fargas O., and Bismuth H. Liver cell adenoma. A 12-year surgical experience from a specialist hepato-biliary unit. Ann Surg 208 (1988) 558-564
48. Lim A.K., Patel N., Eckersley R.J., Taylor-Robinson S.D., Cosgrove D.O., and Blomley M.J. Hepatocellular adenoma: Diagnostic difficulties and novel imaging techniques. Br J Radiol 75 (2002) 695-699
49. Lim A.K., Patel N., Eckersley R.J., Taylor-Robinson S.D., Cosgrove D.O., and Blomley M.J. Evidence for spleen-specific uptake of a microbubbles contrast agent: A quantitative study in healthy volunteers. Radiology 23 (2004) 785-788
50. Morimoto M., Shirato K., Sugimori K., Kokawa A., Tomita N., Saito T., Imada T., Tanaka N., Nozawa A., Numata K., and Tanaka K. Contrast-enhanced harmonic gray-scale sonographic-histological correlation of the therapeutic effects of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. Am J Roentgenol 181 (2003) 65-69
51. Nakamura S., Suzuki S., and Baba S. Resection of liver metastases of colorectal carcinoma. World J Surg 21 (1997) 741-747
52. Nicolau C., Vilana R., and Bru C. The use of contrast-enhanced ultrasound in the management of the cirrhotic patient and for detection of HCC. Eur Radiol 14 Suppl 8 (2004) P63-P71
53. Nicolau C., and Bru C. Focal liver lesions: evaluation with contrast-enhanced ultrasonography. Abdom Imaging 29 (2004) 348-359
54. Nino-Murcia M., Olcott E.W., Jeffrey Jr. R.B., Lamm R.L., Beaulieu C.F., and Jain K.A. Focal liver lesions: Pattern-based classification scheme for enhancement at arterial phase CT. Radiology 215 (2000) 746-751
55. Nordlinger B., Guiguet M., Vaillant J.C., Balladur P., Boudjema K., Bachellier P., and Jaeck D. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie Cancer 77 (1996) 1254-1262
56. Numata K., Isozaki T., Ozawa Y., Sakaguchi T., Kiba T., Kubota T., Ito A., Sugimori K., Shirato K., Morimoto M., and Tanaka K. Percutaneous ablation therapy guided by contrast-enhanced sonography for patients with hepatocellular carcinoma. AJR Am J Roentgenol 180 (2003) 143-149
57. Ohlsson B., Tranberg K.G., Lundstedt C., Ekberg H., and Hederstrom E. Detection of hepatic metastases in colorectal cancer: A prospective study of laboratory and imaging methods. Eur J Surg 159 (1993) 275-281
58. Oldenburg A., Hohmann J., Foert E., Skrok J., Hoffmann C.W., Frericks B., Wolf K.J., and Albrecht T. Detection of hepatic metastases with low MI real time contrast enhanced sonography and SonoVue. Ultraschall Med 26 (2005) 277-284
59. Peschl R., Werle A., and Mathis G. Differential diagnosis of focal liver lesions in signal-enhanced ultrasound using BR 1, a second-generation ultrasound signal enhancer. Dig Dis 22 (2004) 73-80
60. Portugaller H.R., Stacher R., Komaz G., Aschauer M., Hausegger K.A., and Szolar D.H. The value of different spiral CT phases in the detection of liver metastases. Fortsch Roentgenstr 174 (2002) 452-458
61. Raman S.S., Lu D.S., Chen S.C., Sayre J., Eilber F., and Economou J. Hepatic MR imaging using ferrumoxides: Prospective evaluation with surgical and intraoperative sonographic confirmation in 25 cases. AJR Am J Roentgenol 177 4 (2001) 807-812
62. Ros P.R., Menu Y., and Vilgrain V. Liver neoplasms and tumour-like conditions. Eur Radiol 11 Suppl 2 (2001) 145-165
63. Sasaki K., Ito K., Koike S., Fujita T., Okazaki H., and Matsunaga N. Differentiation between hepatic cyst and haemangioma: Additive value of breath-hold, multisection fluid-attenuated inversion-recovery magnetic resonance imaging using half-Fourier acquisition single-shot turbo-spin-echo sequence. J Magn Reson Imaging 21 (2005) 29-36
64. Schmidt J., Strotzer M., Fraunhofer S., Boedeker H., and Zirnbibl H. Intraoperative ultrasonography versus helical computed tomography and computed tomography with arterioportography in diagnosing colorectal liver metastases: Lesion-by-lesion analysis. World J Surg 24 (2000) 43-48
65. Schneider M., Arditi M., Barrau M.B., Brochot J., Broillet A., Ventrone R., and Yan F. BR1: A new ultrasonographic contrast agent based on sulphur hexafluoride-filled microbubbles. Invest Radiol 30 (1995) 451-457
66. Schreve R.H., Terpstra O.T., Ausema L., Lameris J.S., van Seijen A.J., and Jeekel J. Detection of liver metastases. A prospective study comparing liver enzymes, scintigraphy, ultrasonography and computed tomography. Br J Surg 71 (1984) 947-949
67. Sjösteen A.K., and Elvin A. Intra-operative uses of contrast-enhanced ultrasound. Eur Radiol 14 Suppl 8 (2004) P87-P95
68. Sodhi K.S., Sidhu R., Gulati M., Saxena A., Suri S., and Chawla Y. Role of tissue harmonic imaging in focal hepatic lesions: Comparison with conventional sonography. J Gastroenterol Hepatol 20 (2005) 1488-1493
69. Solbiati L., Tonolini M., Cova L., and Goldberg N. The role of contrast-enhanced ultrasound in the detection of focal liver lesions. Eur Radiol 11 Suppl 3 (2001) E15-E26
70. Solbiati L., Tonolini M., and Cova L. Guidance and control of percutaneous treatments. In: Solbiati L., Martegani A., and Leen E. (Eds). Contrast-enhanced ultrasound of liver disease (2003), Springer-Verlag, Rome, Italy 103-113
71. Solbiati L., Tonolini M., and Bellobuono A. Hepatic adenoma. In: Solbiati L., Martegani A., and Leen E. (Eds). Contrast-enhanced ultrasound of liver disease (2003), Springer-Verlag, Rome, Itay 52-55
72. Strobel D., Räkar S., Martus P., Hahn E., and Becker D. Harmonic imaging (Phaseninversionstechnik) in der Differenzierung benigner und maligner Leberläsionen. Ultraschall Med 22 (2001) 105
73. Strobel D., Kleinecke C., Hänsler J., Frieser M., Händl T., Hahn E.G., and Bernatik T. Contrast-enhanced sonography for the characterisation of hepatocellular carcinomas. Correlation with histological differentiation. Ultraschall Med 26 (2005) 270-276
74. Takigawa Y., Sugawara Y., Yamamoto J., Shimada K., Yamasaki S., Kosuge T., and Makuuchi M. New lesions detected by intraoperative ultrasound during liver resection for hepatocellular carcinoma. Ultrasound Med Biol 27 (2001) 151-156
75. Tanaka S., Kitamura T., Imaoka S., Sasaki Y., Taniguchi H., and Ishiguro S. Hepatocellular carcinoma: Sonographic and histological correlation. AJR Am J Roentgenol 140 (1983) 701-707
76. Tanaka S., Kitamura T., Ohshima A., Umeda K., Okuda S., Ohtani T., Tatsuta M., and Yamamoto K. Diagnostic accuracy of ultrasonography for hepatocellular carcinoma. Cancer 58 (1986) 344-347
77. Tanaka S., Kitamura T., Nakanishi K., Okuda S., Kojima J., and Fujimoto I. Recent advances in ultrasonographic diagnosis of hepatocellular carcinoma. Cancer 63 (1989) 1313-1317
78. Tocchi A., Mazzoni G., Brozzetti S., Miccini M., Cassini D., and Bettelli E. Hepatic resection in stage IV colorectal cancer: prognostic predictors of outcome. Int J Colorectal Dis 19 (2004) 580-585
79. Torzilli G., Del Fabbro D., Olivari N., Calliada F., Montorsi M., and Makuuchi M. Contrast-enhanced ultrasonography during liver surgery. Br J Surg 91 (2004) 1165-1167
80. Torzilli G., Olivari N., Moroni E., Del Fabbro D., Gambetti A., Leoni P., Montorsi M., and Makuuchi M. Contrast-enhanced intraoperative ultrasonography in surgery for hepatocellular carcinoma in cirrhosis. Liver Transpl 10 Suppl 1 (2004) S34-S38
81. Torzilli G., Del Fabbro D., Palmisano A., Donadon M., Bianchi P., Roncalli M., Balzarini L., and Montorsi M. Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases. J Gastrointest Surg 9 (2005) 1148-1153 discussion 1153-1154
82. Tsai H.P., Jeng L.B., Lee W.C., and Chen M.F. Clinical experience of hepatic hemangioma undergoing hepatic resection. Dig Dis Sci 48 (2003) 916-920
83. Valls C., Andia E., Sanchez A., Guma A., Figueras J., Torras J., and Serrano T. Hepatic metastases from colorectal cancer: Preoperative detection and assessment of resectability with helical CT. Radiology 218 (2001) 55-60
84. Van Erkel A.R., Pijl M.E., van den Berg-Huysmans A.A., Wasser M.N., van de Velde C.J., and Bloem J.L. Hepatic metastases in patients with colorectal cancer: Relationship between size of metastases, standard of reference, and detection rates. Radiology 224 (2002) 404-409
85. Von Herbay A., Vogt C., Willers R., and Haussinger D. Real-time imaging with he sonographic contrast agent SonoVue: Differentiation between benign and malignant hepatic lesions. J Ultrasound Med 23 (2004) 1557-1568
86. Zacherl J., Scheuba C., Imhof M., Zacherl M., Langle F., Pokieser P., Wrba F., Wenzl E., Muhlbacher F., Jakesz R., and Steininger R. Current value of intraoperative sonography during surgery for hepatic neoplasms. World J Surg 26 (2002) 550-554