Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 21, 2007, Pages 5825-5830

  Gore, Vijay K ^a   Ma, Vu V ^a   Tamir, Rami ^a   Gavva, Narender R ^a   Treanor, James J S ^a   Norman, Mark H ^a  

^a AMGEN INC   (United States)

Author keywords

Biaryl imidazoles; TRPV1; TRPV1 antagonists; Vanilloid receptor 1; VRI

Indexed keywords

CAPSAICIN; IMIDAZOLE DERIVATIVE; RECEPTOR BLOCKING AGENT; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALCIUM TRANSPORT; CHO CELL; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; IMIDAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 34548858716     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.044     Document Type: Article

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