Injectable form of cross-linked hyaluronan is effective for middle ear wound healing

Annals of Otology, Rhinology and Laryngology

Volumn 116, Issue 9 I, 2007, Pages 667-673

  Angeli, Simon ^a   Connell, Sarah ^a   Gibson, Brian ^a   Ozdek, Ali ^a   McElveen Jr , John T ^b   Van De Water, Thomas R ^a  

^a UNIVERSITY OF MIAMI EAR INSTITUTE   (United States)

^b Carolina Ear Research Institute   (United States)

Author keywords

Adhesion; Hyaluronan; Hyaluronic acid; Middle ear; Ototoxicity; Tympanoplasty

Indexed keywords

COLLAGEN SPONGE; GELFOAM; HYALURONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DISTORTION PRODUCT OTOACOUSTIC EMISSION; EVOKED BRAIN STEM AUDITORY RESPONSE; GEL; GUINEA PIG; HEARING LOSS; INFLAMMATION; INFLAMMATORY CELL; MIDDLE EAR; NONHUMAN; PREOPERATIVE PERIOD; PRIORITY JOURNAL; SAFETY; WOUND HEALING;

EID: 34548848023     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940711600908     Document Type: Article

References (16)

1. Hellstrom S, Salen B, Stentors LE. Absorbable gelatin sponge (Gelfoam) in otosurgery: one cause of undesirable post-operative results? Acta Otolaryngol (Stockh) 1983;96:269-75.
2. Laurent C, Hellstrom S, Stenfors LE. Hyaluronic acid reduces connective tissue formation in middle ears filled with absorbable gelatin sponge: an experimental study. Am J Otolaryngol 1986;7:181-6.
3. Liening DA, Lundy L, Silberberg B, Finstuen K. A comparison of the biocompatibility of three absorbable hemostatic agents in the rat middle ear. Otolaryngol Head Neck Surg 1997; 116:454-7.
4. Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 2004;4:528-39.
5. Laurent TC. Biochemistry of hyaluronan. Acta Otolaryngol Suppl (Stockh) 1987(suppl 442):7-24.
6. Laurent C, Hellstrom S, Anniko M. Inner ear effects of exogenous hyaluronan in the middle ear of the rat. Acta Otolaryngol (Stockh) 1988;105:273-80.
7. Li G, Feghali JG, Dinces E, McElveen J, van de Water TR. Evaluation of esterified hyaluronic acid as middle ear-packing material. Arch Otolaryngol Head Neck Surg 2001;127:534-9.
8. Stenfors LE, Berghem L, Bloom GD, Hellstrom S, Soderberg O. Exogenous hyaluronic acid (Healon) accelerates the healing of experimental myringotomies. Auris Nasus Larynx 1985;12(suppl 1):S214-S215.
9. Krupala JL, Gianoli GJ, Smith RA. The efficacy of hyaluronic acid foam as a middle ear packing agent in experimental tympanoplasty. Am J Otol 1998;19:546-50.
10. Bagger-Sjöbäck D. Sodium hyaluronate application to the open inner ear: an ultrastructural investigation. Am J Otol 1991;12:35-9.
11. Spandow O, Hellstrom S. Healing of tympanic membrane perforation - a complex process influenced by a variety of factors [in Swedish]. Acta Otolaryngol Suppl (Stockh) 1992(suppl 492):90-3.
12. Martini A, Morra B, Aimoni C, Radice M. Use of a hyaluronan-based biomembrane in the treatment of chronic cholesteatomatous otitis media. Am J Otol 2000;21:468-73.
13. Laurent C, Hellstrom S, Fellenius E. Hyaluronan improves the healing of experimental tympanic membrane perforations. A comparison of preparations with different rheologic properties. Arch Otolaryngol Head Neck Surg 1988;114:1435-41.
14. Hellstrom S, Laurent C. Hyaluronan and healing of tympanic membrane perforations. An experimental study. Acta Otolaryngol Suppl (Stockh) 1987(suppl 442):54-61.
15. Laurent C, Hellstrom S, Appelgren LE, Sehlin J, Lilja K. Fate of exogenous hyaluronic acid in the middle ear. Am J Otolaryngol 1986;7:334-40.
16. Angeli SI. Hyaluronate gel stapedotomy. Otolaryngol Head Neck Surg 2006;134:225-31.