Subchronic heavy metal and alcohol treatment in rats: Changes in the somatosensory evoked cortical activity

Acta Biologica Hungarica

Volumn 58, Issue 3, 2007, Pages 259-267

  Lukács, Anita ^a   Lengyel, Zsuzsanna ^a,b   Institoris L ^a   Szabó, Andrea ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b GEDEON RICHTER LTD   (Hungary)

Author keywords

Alcohol; Combination; Lead; Mercury; Neurotoxicity; Rat

Indexed keywords

ALCOHOL; CENTRAL DEPRESSANT AGENT; LEAD; MERCURY;

ANIMAL; BLOOD BRAIN BARRIER; CONFERENCE PAPER; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; EVOKED SOMATOSENSORY RESPONSE; LEAD POISONING; MALE; MERCURIALISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SOMATOSENSORY CORTEX; TOXICITY AND INTOXICATION; VIBRISSA; WISTAR RAT;

ANIMALS; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ETHANOL; EVOKED POTENTIALS, SOMATOSENSORY; LEAD; LEAD POISONING; MALE; MERCURY; MERCURY POISONING; NEUROTOXICITY SYNDROMES; RATS; RATS, WISTAR; SOMATOSENSORY CORTEX; VIBRISSAE;

RATTUS; RATTUS NORVEGICUS;

EID: 34548838576     PISSN: 02365383     EISSN: 1588256X     Source Type: Journal    
DOI: 10.1556/ABiol.58.2007.3.2     Document Type: Conference Paper

References (21)

1. Araki, S., Sato, H., Yokoyama, K., Murata, K. (2000) Subclinical neurophysiological effects of lead: A review on peripheral, central, and autonomic nervous system effects in lead workers. Am. J. Ind. Med. 37, 193-204.
2. Braga, M. F. M., Pereira, E. F. R., Albuquerque, E. X. (1999) Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res. 826, 22-34.
3. Brookes, N. (1992) In vivo evidence for the role of glutamate in the CNS toxicity of mercury. Toxicology 76, 245-256.
4. Büsselberg, D. (1995) Calcium channels as target sites of heavy metals. Toxicol. Lett. 82, 255-261.
5. Dally, S., Girre, C., Hispand, E., Tomoas, G., Fournier, I. (1989) High blood lead levels in alcoholics, wine vs. beer. Drug. Alcohol Depend. 23, 45-48.
6. Dieter, M. P., Boorman, G. A., Jameson, C. W. (1992) Development of renal toxicity in F344 rats gavaged with mercuric chloride for 2 weeks, or 2, 4, 6, 15, and 24 months. J. Toxicol. Environ. Health 36, 319-340.
7. Discalzi, G., Fabbro, D., Meliga, F., Mocellini, A., Capellaro, F. (1993) Effects of occupational exposure to mercury and lead on brainstem auditory evoked potentials. J. Psychophysiol. 14, 21-25.
8. Gulati, A., Chandishwar, N., Schanker, K., Srimal, R. C., Dhawan, K. N., Bhargava, K. P. (1985) Effect of alcohols on the permeability of blood-brain barrier. Pharmacol. Res. Commun. 17, 85-93.
9. Lille, F., Hazemann, P., Garnier, R., Dally, S. (1988) Effects of lead and mercury intoxications on evoked potentials. J. Toxicol. Clin. Toxicol. 26, 103-116.
10. Maranelli, G., Apostoli, P., Ferrari, P. (1990) Influence of smoking, alcohol and dietary habits on blood Pb and Cd levels. Bull. Environ. Contam. Toxicol. 45, 804-810.
11. Nagymajtényi, L., Dési, I., Papp, A., Vezér, T. (2000) Experimentally induced functional changes of the nervous system caused by subchronic combined administration of heavy metals and an organophosphate pesticide. Centr. Eur. J. Public Health 8, 64-65.
12. Olsen, R. W., Avoli, M. (1997) GABA and epileptogenesis. Epilepsia 38, 399-407.
13. Papp, A., Baydar, T., Vezér, T., Nagymajtényi, L. (2000) Changes in certain dynamic features of sensory evoked potentials of rats on exposure to metal xenobiotics. Centr. Eur. J. Occup. Envir. Med. 6, 202-208.
14. Papp, A., Nagymajtényi, L., Vezér, T. (2005) Subchronic mercury treatment of rats in different phases of ontogenesis: functional effects on the central and peripheral nervous system. Food Chem. Toxicol. 43, 77-85.
15. Papp, A., Pecze, L., Vezér, T. (2004) Dynamics of central and peripheral evoked electrical activity in the nervous system of rats exposed to xenobiotics. Centr. Eur. J. Occup. Envir. Med. 10, 52-59.
16. Pecze, L., Papp, A., Nagymajtényi, L. (2003) Acute effects of lead and mercury on the central and peripheral nervous system in rats pretreated with alcohol. Centr. Eur. J. Occup. Envir. Med. 9, 253-262.
17. Piikivi, L., Tolonen, U. (1989) EEG findings in chloralkali workers subjected to low long term exposure to mercury vapour. Br. J. Ind. Med. 46, 370-375.
18. Strubelt, O. (1984) Alcohol potentiation of liver injury. Fundam. Appl. Toxicol. 4, 144-151.
19. Vezér, T., Papp, A., Kurunczi, A., Párducz, Á., Náray, M., Nagymajtényi, L. (2005) Behavioral and neurotoxic effects seen during and after subchronic exposure of rats to organic mercury. Env. Toxicol. Pharmacol. 19, 785-796.
20. Vezér, T., Schulz, H., Nagymajtényi, L. (2000) Memory effect of neurotoxic lead compounds in subacute animal experiments. Centr. Eur. J. Occup. Environ. Med. 6, 209-216.
21. Yokoyama, K., Araki, S. (1992) Assessment of axonal transport in lead-exposed rats. Environ. Res. 59, 4440-4446.